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| Name | Class |
|---|---|
| Universitat Politècnica de Catalunya | OTHER |
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Precise identification of the infarct scar is essential for successful catheter ablation of ventricular arrhythmias in patients with chronic myocardial infarction. Voltage mapping of endocardial electrograms is currently used to delineate the necrotic scar but this is influenced by the direction of the activation wave front and is not sensitive enough to differentiate distinct degrees of transmural injury in the scar. Mapping of local myocardial electrical impedance may overcome these limitations.
Clinical series: Patients with chronic infarction undergoing catheter ablation of ventricular arrhythmias will be submitted to mapping of both voltage and tissue impedance. Likewise, the accuracy of the two maps identifying the extent and transmurality of the infarction will be assesssed by gadolinium imaging. The impedance system is already constructed and certified for clinical research use.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| CASE GROUP | patients with chronic infarction undergoing catheter ablation of ventricular arrhythmias |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| CardioZ multifrequency impedance recording system | Device | Patients will be submitted to mapping of both voltage and tissue impedance. The accuracy of the two maps identifying the extent and transmurality of the infarction will be assesssed by gadolinium imaging. |
| Measure | Description | Time Frame |
|---|---|---|
| Comparative detection of infarct scar by voltage mapping | Voltage will be measured at different sites of the infarct scar and healthy tissue. | 3 hours |
| Comparative detection of infarct scar by impedance mapping | myocardial local impedance will be measured at different sites of the infarct scar and healthy tissue. | 3 hours |
| Comparative detection of infarct scar by gadolinium enhanced MR imaging | Intensity of gadolinium will be measured at different sites of the infarct scar and healthy tissue. | 30 minutes |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with chronic myocardial infarction undergoing ablation of ventricular arrhythmias.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Juan Cinca Cuscullola, Professor | Contact | +34935537058 | jcinca@santpau.cat | |
| Laia Angli | Contact | +34935537058 | langli@santpau.cat |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hospital de la Santa Creu i Sant Pau | Recruiting | Barcelona | 08026 | Spain |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 29197656 | Background | Amoros-Figueras G, Jorge E, Alonso-Martin C, Traver D, Ballesta M, Bragos R, Rosell-Ferrer J, Cinca J. Endocardial infarct scar recognition by myocardial electrical impedance is not influenced by changes in cardiac activation sequence. Heart Rhythm. 2018 Apr;15(4):589-596. doi: 10.1016/j.hrthm.2017.11.031. Epub 2017 Dec 27. | |
| 26608340 |
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| Jorge E, Amoros-Figueras G, Garcia-Sanchez T, Bragos R, Rosell-Ferrer J, Cinca J. Early detection of acute transmural myocardial ischemia by the phasic systolic-diastolic changes of local tissue electrical impedance. Am J Physiol Heart Circ Physiol. 2016 Feb 1;310(3):H436-43. doi: 10.1152/ajpheart.00754.2015. Epub 2015 Nov 25. |
| 27630580 | Background | Amoros-Figueras G, Jorge E, Garcia-Sanchez T, Bragos R, Rosell-Ferrer J, Cinca J. Recognition of Fibrotic Infarct Density by the Pattern of Local Systolic-Diastolic Myocardial Electrical Impedance. Front Physiol. 2016 Aug 31;7:389. doi: 10.3389/fphys.2016.00389. eCollection 2016. |
| ID | Term |
|---|---|
| D009203 | Myocardial Infarction |
| ID | Term |
|---|---|
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D014652 | Vascular Diseases |
| D007238 | Infarction |
| D007511 | Ischemia |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D009336 | Necrosis |
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