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This retrospective cohort study is to identify triggers of heart failure (HF) development and drivers of HF progression as well as the underlying cardiac disease (phenotype) to identify patients at risk and predict the clinical course of the disease. Data of patients who were hospitalized during the years 2010-2023 with acute coronary syndrome (ACS) and/ or with acute heart failure (AHF) will be collected and analyzed. In a subgroup cohort efficacy and safety of digoxin in patients with acute heart failure triggered by tachyarrhythmia will be evaluated.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| acute coronary syndrome (ACS) | Outcome information (all-cause death, heart failure (HF) hospitalizations) of patients hospitalized with a primary diagnosis of ACS is analyzed. |
| |
| acute heart failure (AHF) | Outcome information (all-cause death, heart failure (HF) hospitalizations) of patients hospitalized with a primary or secondary diagnosis of AHF is analyzed. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| medical chart review | Other | data generated by medical review include Medical history, Medications at presentation, during hospitalization and at discharge, New York Heart Association (NYHA) class, Killip class, Electrocardiographic (ECG) data, echocardiographic data, Interventions (Percutaneous Coronary Intervention (PCI), Coronary Artery Bypass Graft (CABG), Implantable Cardioverter Defibrillator (ICD) implantation, Cardiac Resynchronization Therapy (CRT) Implantation), Outcome Information: all-cause death, HF hospitalizations |
| Measure | Description | Time Frame |
|---|---|---|
| number of all-cause death | number of all-cause death in patients hospitalized with ACS and AHF during the years 2010-2023. | 1 to 8 years after hospitalization |
| number of HF hospitalizations | number of new HF hospitalizations in patients hospitalized with ACS and AHF during the years 2010-2023 | 1 to 8 years after hospitalization |
| number of cardiovascular death | number of cardiovascular death in patients hospitalized with ACS and AHF | 1 to 8 years after hospitalization |
| number of cardiovascular hospitalizations | number of cardiovascular hospitalizations | 1 to 8 years after hospitalization |
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Inclusion Criteria:
Exclusion Criteria:
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Patients that were hospitalized at the Universitätsspital Basel/ Switzerland with the diagnosis of ACS or AHF during the years 2010 - 2023
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Christian Müller, Prof. Dr. | Contact | 0041 6132 86 549 | Christian.mueller@usb.ch | |
| Fiona Nafaa, MD | Contact | +41 61 32 87747 | fiona.nafaa@usb.ch |
| Name | Affiliation | Role |
|---|---|---|
| Christian Müller, Prof. Dr. | Cardiology University Hospital Basel | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Cardiology, University Hospital Basel | Recruiting | Basel | 4031 | Switzerland |
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| ID | Term |
|---|---|
| D054058 | Acute Coronary Syndrome |
| D006333 | Heart Failure |
| ID | Term |
|---|---|
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D014652 | Vascular Diseases |
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| data generated by direct IT export | Other | data generated by direct IT export include Anthropometric data (age, sex, height, weight), Vital signs, Laboratory data |
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