An Experimental Study to Compare Treatment Response and Toxicities of Concurrent Chemoradiation With Weekly Cisplatin and Three Weekly Cisplatin in Locally Advanced Head and Neck Cancer.

Comparison Between Two Regimens of Chemotherapy Concurrent With Radiotherapy in Locally Advanced Head and Neck Cancer

The aim of this study is to compare treatment responses and toxicities of concurrent chemo-radiation with weekly and three weekly Cisplatin in locally advanced Head & Neck Cancer. Half of the participants received Cisplatin (40 mg/m2) weekly with radiotherapy, while the other half received Cisplatin (100 mg/m2) thrice weekly with radiotherapy. Radiotherapy continued five days per week for six and half weeks.

Inclusion Criteria:

• Biopsy proved, previously untreated, Squamous cell carcinoma of head & neck
• Stages III to IVB

Exclusion Criteria:

• Patients with history of prior chemotherapy or radiotherapy to the head and neck region.
• Initial surgery (excluding diagnostic biopsy) of the primary site.
• Patients with synchronous primaries.
• Those who are not willing to be included in the study.
• Pregnant or lactating woman.
• Serious medical illness
• Prisoners.