The purpose of this phase 3 study is to evaluate the efficacy and safety of an analgesic drug candidate, VVZ-149 Injections for treating post-operative pain following abdominoplasty.

Inclusion Criteria:

• Men and women between 18-70 years old, inclusive. Female subjects must meet additional criteria according to childbearing potential.
• Planning to undergo abdominoplasty
• Ability to provide written informed consent
• Ability to understand study procedures and communicate clearly with the investigator and staff
• American Society of Anesthesiologists (ASA) risk class of I to II.

Exclusion Criteria:

• Emergency or unplanned surgery
• Previous abdominoplasty
• Pre-existing condition causing preoperative pain around the site of surgery
• Women who are pregnant or breastfeeding
• Chronic pain diagnosis and ongoing or frequent use of pain medications