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| Name | Class |
|---|---|
| Assistance Publique - Hôpitaux de Paris | OTHER |
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Gene therapy is a promising strategy to treat hearing loss and vestibular disorders, and Associated adenovirus (AAV) is shown as a good viral vector for inner ear therapy in animal models.
This study aims to study in vitro viral transduction of AAV in human inner ear cells, collected during non-conservative surgeries for vestibular schwannoma.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| AAV viral transduction | Collection of inner ear cells during a non-conservative surgical approach (translabyrinthine or transotic). |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Peroperative collect of inner ear cells | Other | After obtaining an informed consent during the preoperative medical visit, and if a non-conservative approach (translabyrinthine or transotic) is decided, the collect of inner ear cells will be performed during surgical approach. The sample will be collect in a sterile tube, and carried to the laboratory were it will be placed bon cell culture. |
| Measure | Description | Time Frame |
|---|---|---|
| AAV transduction in inner ear cells | The transduction will be measured with immunostaining techniques | 10 days |
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Inclusion Criteria:
Exclusion Criteria:
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Patients undergoing surgical resection of vestibular schwannoma.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Ghizlene Lahlou | Contact | 33 1 45688891 | ghizlene.lahlou@pasteur.fr | |
| Saaid Safieddine | Contact | saaid.safieddine@pasteur.fr |
| Name | Affiliation | Role |
|---|---|---|
| Ghizlene Lahlou | Institut Pasteur | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hôpital de Bicêtre | Recruiting | Le Kremlin-Bicêtre | Île-de-France Region | 94270 | France |
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| ID | Term |
|---|---|
| D006319 | Hearing Loss, Sensorineural |
| ID | Term |
|---|---|
| D034381 | Hearing Loss |
| D006311 | Hearing Disorders |
| D004427 | Ear Diseases |
| D010038 | Otorhinolaryngologic Diseases |
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inner ear cells collected during surgery
|
| Hôpital Pitié-Salpétrière | Recruiting | Paris | Île-de-France Region | 75015 | France |
|
| D012678 |
| Sensation Disorders |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |