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| Name | Class |
|---|---|
| Business Finland | OTHER |
| Valio Ltd | INDUSTRY |
| Finnish Red Cross Blood Service | OTHER |
| DuPont Nutrition and Health |
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The aim of this cohort is to identify environmental, lifestyle and genetic factors that modify the human intestinal microbiota development during the first years of life, and to identify early microbiota features that associate to child health and well-being with focus on the development of allergic diseases and overweight.
1055 healthy term infants born in 2016-2018 mainly at the capital region of Finland, and their parents. Fecal samples collected from infants and their parents. Electronic questionnaires on a weekly basis during the first 4 months of life, thereafter less frequently. Focus on diet, well-being and health and social manners. At one-year and at two-years comprehensive questionnaires including development and cognition. Parental stress evaluation included.
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| Measure | Description | Time Frame |
|---|---|---|
| Longitudinal change of intestinal microbiota in early life | Developmental trajectory of the intestinal microbiota, assessed with 16S rRNA gene amplicon and shotgun sequencing of fecal DNA to determine the changes in the intestinal microbiota composition, diversity and functionality from week 3 to weeks 6,9,12 and months 6,9,12,18 and 24 after birth. | From 3 weeks to 2 years after birth |
| Measure | Description | Time Frame |
|---|---|---|
| Number of children with asthma | Specialist/Physician-diagnosed asthma. | At 2 years |
| Number of children with allergic disease | Specialist/Physician-diagnosed wheeze, eczema/atopic dermatitis, allergic rhinitis, food allergy or atopy. |
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Inclusion Criteria:
Exclusion Criteria
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The cohort consists of 1055 healthy term infants born in 2016-2018 mainly at the capital region of Finland, and their parents.
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| Name | Affiliation | Role |
|---|---|---|
| Willem M de Vos, Professor | University of Helsinki | Study Director |
| Anne Salonen, PhD | University of Helsinki | Principal Investigator |
| Kaija-Leena Kolho, Professor | University of Helsinki | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Human Microbiome Research Program, Faculty of Medicine, University of Helsinki | Helsinki | Finland |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34857814 | Derived | Korpela K, Kallio S, Salonen A, Hero M, Kukkonen AK, Miettinen PJ, Savilahti E, Kohva E, Kariola L, Suutela M, Tarkkanen A, de Vos WM, Raivio T, Kuitunen M. Gut microbiota develop towards an adult profile in a sex-specific manner during puberty. Sci Rep. 2021 Dec 2;11(1):23297. doi: 10.1038/s41598-021-02375-z. | |
| 31253623 | Derived |
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| ID | Term |
|---|---|
| D006967 | Hypersensitivity |
| D050177 | Overweight |
| D003141 | Communicable Diseases |
| D000073296 | Noncommunicable Diseases |
| ID | Term |
|---|---|
| D007154 | Immune System Diseases |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
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| INDUSTRY |
| Oriola Corporation | UNKNOWN |
| Pikkujätti Medical Centre for Children and Youth | UNKNOWN |
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| At 2 years |
| Number of respiratory tract infection episodes | Number of physician-diagnosed respiratory track infections. | From birth to 2 years of age |
| Weight | Weight in kilograms. | At 6,12,18 and 24 months after birth |
| Growth | Height in centimeters. | At 6,12,18 and 24 months after birth |
| Child development | By means of questionnaires and, on a randomly selected group of study subjects, developmental testing to assess cognitive, motor, socio-emotional and verbal development. | At 18 and 24 months after birth |
| Korpela K, Dikareva E, Hanski E, Kolho KL, de Vos WM, Salonen A. Cohort profile: Finnish Health and Early Life Microbiota (HELMi) longitudinal birth cohort. BMJ Open. 2019 Jun 27;9(6):e028500. doi: 10.1136/bmjopen-2018-028500. |
| D001835 | Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D007239 | Infections |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |