I. To investigate whether patient characteristics, exercise therapy characteristics, local metabolic exercise response, endothelial function, autonomic function or atherosclerotic lesion location can predict the walking response to a successfully completed semi-supervised exercise intervention in patients with intermittent claudication (WP I) II. To assess the effect of a home-based exercise intervention with remote monitoring and coaching on cardiovascular risk factors in patients with intermittent claudication (WP II)

The study population will comprise patients diagnosed with lower-extremity artery disease (ABI ≤0.9 and/or 20% decrease after a maximal treadmill test) suffering from intermittent claudication (Rutherford 1-3) presenting with new complaints (at least 6 months after previous revascularization) at the Vascular Center of university hospitals Leuven will be included if according to current guidelines their initial treatment should be conservative

Inclusion Criteria:

• age > 17 yrs
• ABI ≤0.9 and/or 20% decrease after a maximal treadmill test
• intermittent claudication (Rutherford 1-3)
• ability to undertake an exercise test and read and understand Dutch questionnaires

Exclusion criteria

• exercise test induced signs of complex arrhythmias or significant ischemia during baseline testing
• other comorbidity limiting participation in the exercise group