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Reducing discomfort in the intensive care unit (ICU) should be beneficial to longterm outcomes. This study assesses whether a tailored multicomponent program for discomfort reduction may be effective in reducing post-traumatic stress disorder (PTSD) symptoms at 1-year in general ICU survivors.
The psychiatric morbidity may be increased by the COVID-19 epidemic and its consequences on the healthcare system (patient care, reorganization of French ICUs). The main objective of PTSD-REA_COVID cohort is to assess this psychiatric morbidity 6 months after an ICU stay during the epidemic period.
After carrying out the cluster-randomized controlled IPREA3 study demonstrating that a tailored multicomponent program based on assessment of self-perceived discomfort, feedback to the healthcare teams, and tailored site-targeted measures was effective to decrease self-perceived overall discomfort, we performed the 1-year follow-up of ICUs survivors included in the IPREA3 study to assess psychiatric morbidity at 1 year. Our tailored multicomponent program was also associated with less PTSD at 1 year after ICU discharge. Based on this positive long-term result, this study confirms the need to implement a new strategy for reducing discomfort in the ICU based on such programs.
PTSD-REA is a stepped wedge cluster randomized trial involving 18 ICUs. The exposure will be the implementation of a tailored multicomponent program consisting of assessment of ICU-related self-perceived discomforts, immediate and monthly feedback to the healthcare team, and site-specific tailored interventions. The eligible patients will be exposed vs. unexposed general adult ICU survivors. The prevalence of substantial posttraumatic stress disorder (PTSD) symptoms at 1 year will be assessed by using diagnostic criteria adapted to the new definition of PTSD according to DSM-5.
The current context of the COVID-19 pandemic has considerably disrupted the ICUs organizations as well as the patients care which may lead to increased psychiatric morbidity. In this context, it seems necessary to assess this phenomenon in order to anticipate the consequences on patients but also on the healthcare system. The objectives of the PTSD-REA_COVID cohort are to assess the prevalence of PTSD symptoms, 6 months after ICU stay during COVID-19 epidemic and to compare the psychiatric morbidity at 1 year after an ICU stay during epidemic period and non epidmic period.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| IPREA3 program | Experimental | Application of the IPREA 3 program (multicomponent intervention to reduce perceived discomforts in critically ill patients) for at least 5 months |
|
| Intermediate group | Other | Application of the IPREA 3 program (multicomponent intervention to reduce perceived discomforts in critically ill patients) for less than 5 months |
|
| Standard care | Active Comparator | Standard care |
|
| PTSD-REA_COVID cohort | Other | ICU admission between March 1, 2020 and April 30, 2020. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Administration of the IPREA3 questionnaire | Other | On the day of the ICU discharge, the bedside nurse administers to the patient the 18-item IPREA questionnaire i.e the nurse asks the patient to rate from 0 to 10 the severity of each discomfort source contained in the IPREA3 questionnaire experienced during the entire stay in the ICU |
| Measure | Description | Time Frame |
|---|---|---|
| Presence of posttraumatic stress disorder (PTSD) symptoms at one year after ICU discharge and 6 months ( PTSD-REA_COVID cohort) | PTSD symptoms at one year will be assessed from the PCL-5 which is a 20-item self-report measure that assesses the 20 DSM-5 (Diagnostic and Statistical Manual of Mental Disorders) symptoms of PTSD. Each item is rated from 0 "Not at all" to 4 "Extremely". A total symptom severity score (range - 0-80) can be obtained by summing the scores for each of the 20 items. A provisional PTSD diagnosis can be made by treating each item rated as 2 = "Moderately" or higher as a symptom endorsed, then following the DSM-5 diagnostic rule which requires at least: 1 B item (questions 1-5), 1 C item (questions 6-7), 2 D items (questions 8-14), 2 E items (questions 15-20). | One year after ICU discharge |
| Measure | Description | Time Frame |
|---|---|---|
| ICU stay's duration | The day of ICU discharge | |
| Number of days with mechanical ventilation | The day of ICU discharge | |
| Overall score of discomfort assessed from the IPREA3 questionnaire |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Pierre KALFON, MD PhD | CH Chartres | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU Angers | Angers | 49100 | France | |||
| CHU d'Angers |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 23084614 | Result | Jones C. Surviving the intensive care: residual physical, cognitive, and emotional dysfunction. Thorac Surg Clin. 2012 Nov;22(4):509-16. doi: 10.1016/j.thorsurg.2012.07.003. Epub 2012 Aug 25. | |
| 14530751 | Result | Jones C, Skirrow P, Griffiths RD, Humphris GH, Ingleby S, Eddleston J, Waldmann C, Gager M. Rehabilitation after critical illness: a randomized, controlled trial. Crit Care Med. 2003 Oct;31(10):2456-61. doi: 10.1097/01.CCM.0000089938.56725.33. |
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Stepped wedge cluster randomized trial
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| Immediate feedback through electronic reminder messages | Other | After the nurse had administered the questionnaire, warning messages are displayed on the screen corresponding to the key points to prevent the three discomforts reported with the highest scores |
|
| Targeted interventions in each ICU to reduce discomforts | Other | These targeted interventions are implemented through the coordination of two local champions. The central coordination IPREA3 team sends each month to the local champions monthly and cumulative discomfort scores of their unit (overall score of discomfort and scores for each item) and their ranking relative to other units assigned to the interventional arm i.e applying the IPREA3 program. The local champions organize monthly meetings with the unit staff to present the results in terms of perceived discomforts measured by the IPREA questionnaire, identify main discomfort sources and actions to be conducted to reduce the discomforts reported with the highest scores in the unit and those that are most easily preventable, and assess the efficacy of already applied measures. |
|
| 6 months follow-up to assess the prevalence of PTSD symptoms | Other | Psychologist will collect the PCL-5, HAD-S, WHOQOL-BREF, LEC-5 items during the telephone follow-up, 6 months after ICU discharge . |
|
| 1 year follow-up to assess psychiatric morbidity | Other | Psychologist will collect the PCL-5, HAD-S, WHOQOL-BREF, LEC-5 and CTQ items during the telephone follow-up, 1 year after ICU discharge . |
|
| The day of ICU discharge |
| The duration of hospital stay after ICU discharge | 6 months ( PTSD-REA_COVID cohort) or 1 year after ICU discharge and |
| Intrusion Symptom Category B assessed from the PCL-5 (Posttraumatic Stress Disorder Checklist ) (Items 1-5) | Recurrent or involuntary distressing dreams, memories, thoughts, or feelings related to the traumatic event(s) | 6 months ( PTSD-REA_COVID cohort) and1 year after ICU discharge |
| Persistent Avoidance Category C assessed from the PCL-5 (Items 6-7) | Avoidance or efforts to avoid internal or external reminders of the traumatic event(s) | 6 months ( PTSD-REA_COVID cohort) and1 year after ICU discharge |
| Negative Alterations in Cognitions and Mood Category D assessed from PCL 5 (Items 8-14) | Persistent and exaggerated negative beliefs about oneself, the world, others, negative mood states, inability to experience positive emotions | 6 months ( PTSD-REA_COVID cohort) and1 year after ICU discharge |
| Alterations in arousal and reactivity Category E assessed from the PCL-5 (Items 15-20) | Marked increase in arousal or reactivity such as irritability, hypervigilance, exaggerated startle response, sleep or concentration problems exaggerated startle response | 6 months ( PTSD-REA_COVID cohort) and1 year after ICU discharge |
| Score of the sub-scale A of the questionnaire HAD-S (Hospital and Anxiety Depression Scale) | Allowing to estimate the presence of anxious symptoms. The scale HAD contains 14 items rated from 0 to 3. The score of Anxiety ( total A) is obtained by summing items 1-3-5-7-9-11-13 and the depressive dimension (total D) is obtained by summing items 2-4-6-8-10-12-14. The maximal note for each of them is 21. 8 points is a minimum threshold for determining whether the anxiety is clinically meaningful | 6 months ( PTSD-REA_COVID cohort) and1 year after ICU discharge |
| Score of the sub-scale D of the questionnaire HAD-S ( Hospital and Anxiety Depression Scale) | Allowing to estimate the presence of anxious symptoms. The scale HAD contains 14 items rated from 0 to 3. The score of Anxiety ( total A) is obtained by summing items 1-3-5-7-9-11-13 and the depressive dimension (total D) is obtained by summing items 2-4-6-8-10-12-14. The maximal note for each of them is 21. 8 points is a minimum threshold for determining whether Depression is clinically meaningful | 6 months ( PTSD-REA_COVID cohort) and1 year after ICU discharge |
| Score obtained from The World Health Organization Quality of Life (WHOQOL-BREF) | The WHOQOL-BREF measure the following broad domains: physical health, psychological health, social relationships, and environment. Each item is rated from 0 to 5. The score of each domain is obtained by summing items then standardized on a scale of 0 (worst quality of life related to health in the dimension explored) to 100 (better quality of liferelated to health in the dimension explored). | 6 months ( PTSD-REA_COVID cohort) and1 year after ICU discharge |
| Number of emergency stays | Since ICU discharge | 6 months ( PTSD-REA_COVID cohort) and1 year after ICU discharge |
| Number of hospitalization | Since ICU discharge | 6 months ( PTSD-REA_COVID cohort) and1 year after ICU discharge |
| Number of psychiatric or psychological consultation | Since ICU discharge | 6 months ( PTSD-REA_COVID cohort) and1 year after ICU discharge |
| The place of leaving after ICU stay | Evaluated in population of patients living at home before the ICU stay. | 6 months ( PTSD-REA_COVID cohort) and1 year after ICU discharge |
| Presence of professional activity | Evaluated in population of patients with a professional activity before ICU stay | 6 months ( PTSD-REA_COVID cohort) and1 year after ICU discharge |
| Angers |
| 49933 |
| France |
| CH d'Auxerre | Auxerre | 89000 | France |
| CH de Blois | Blois | 41016 | France |
| Clinique Convert | Bourg-en-Bresse | 01000 | France |
| CH Bourges | Bourges | 18033 | France |
| Hôpital Louis Pasteur | Chartres | 28000 | France |
| CHU de Dijon | Dijon | 21079 | France |
| CH de Douai | Douai | 59507 | France |
| CH Emile Roux | Le Puy-en-Velay | 43000 | France |
| CH de Lens | Lens | 62300 | France |
| Hôpital Edouard Herriot | Lyon | 69437 | France |
| Hôpital Européen de Marseille | Marseille | 13003 | France |
| Hôpital Nord_APHM | Marseille | 13015 | France |
| Hôpital Nord_APHM | Marseille | 13326 | France |
| CH de Mâcon | Mâcon | 71000 | France |
| CH de l'Agglomération Montargoise | Montargis | 45207 | France |
| GHR Mulhouse Sud-Alsace | Mulhouse | 68100 | France |
| Clinique Ambroise Paré | Neuilly-sur-Seine | 92200 | France |
| Hôpital Pasteur 2_CHU de Nice | Nice | 06006 | France |
| Hôpital Saint-Louis_APHP | Paris | 75010 | France |
| Gaston Cordier_GH La Pitié-Salpêtrière-Charles Foix_APHP | Paris | 75013 | France |
| GH La Pitié-Salpêtrière-Charles Foix_APHP | Paris | 75013 | France |
| Husson Mourier_GH La Pitié-Salpêtrière-Charles Foix_APHP | Paris | 75013 | France |
| CHU de Poitiers | Poitiers | 86021 | France |
| Hôpital privé Claude Galien | Quincy-sous-Sénart | 91480 | France |
| CH Victor Provo | Roubaix | 59100 | France |
| NCT+ - St Gatien | Saint-Cyr-sur-Loire | 37540 | France |
| Nouvel Hôpital Civil_CHU de Strasbourg | Strasbourg | 67091 | France |
| Hôpital de Hautepierre_CHU de Strasbourg | Strasbourg | 67098 | France |
| Hôpital Sainte Musse | Toulon | 83000 | France |
| CHRU de Tours | Tours | 37044 | France |
| CH de Troyes | Troyes | 1000 | France |
| 23247200 | Result | Pacella ML, Hruska B, Delahanty DL. The physical health consequences of PTSD and PTSD symptoms: a meta-analytic review. J Anxiety Disord. 2013 Jan;27(1):33-46. doi: 10.1016/j.janxdis.2012.08.004. Epub 2012 Sep 13. |
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| 38486304 | Derived | Kalfon P, El-Hage W, Geantot MA, Favier C, Bodet-Contentin L, Kuteifan K, Olivier PY, Thevenin D, Pottecher J, Crozon-Clauzel J, Mauchien B, Galbois A, de Varax R, Valera S, Estagnasie P, Berric A, Nyunga M, Revel N, Simon G, Kowalski B, Sossou A, Signouret T, Leone M, Delale C, Seemann A, Lasocki S, Quenot JP, Monsel A, Michel O, Page M, Patrigeon RG, Nicola W, Thille AW, Hekimian G, Auquier P, Baumstarck K; PTSD-REA Study group. Impact of COVID-19 on posttraumatic stress disorder in ICU survivors: a prospective observational comparative cohort study. Crit Care. 2024 Mar 14;28(1):77. doi: 10.1186/s13054-024-04826-1. |
| ID | Term |
|---|---|
| D016638 | Critical Illness |
| D013313 | Stress Disorders, Post-Traumatic |
| D000086382 | COVID-19 |
| ID | Term |
|---|---|
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D040921 | Stress Disorders, Traumatic |
| D000068099 | Trauma and Stressor Related Disorders |
| D001523 | Mental Disorders |
| D011024 | Pneumonia, Viral |
| D011014 | Pneumonia |
| D012141 | Respiratory Tract Infections |
| D007239 | Infections |
| D014777 | Virus Diseases |
| D018352 | Coronavirus Infections |
| D003333 | Coronaviridae Infections |
| D030341 | Nidovirales Infections |
| D012327 | RNA Virus Infections |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
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