Effect of Vitamin D on the Size of Fibroids in Women With Vitamin D Deficiency

Pilot Clinical Study to Evaluate the Effect of Vitamin D on the Size of Fibroids in Women With Vitamin D Deficiency

Vitamin D supplementation in patients with uterine fibroids who present hypovitaminosis D to re-establish their normal serum values could stabilize the size of the uterine fibroids and thus prevent their growth or reduce their size thanks to the anti-proliferative action of Vitamin D on the myoma cells.

Inclusion Criteria:

• Diagnosed with at least one fibroid > 3 cm
• With hypovitaminosis D (25(OH)D < 30 ng/ml)
• BMI < 30
• No hormonal treatment in the 3 months prior to the ultrasound study

Exclusion Criteria:

• Black race
• Symptomatic fibroids subsidiary to hormonal or surgical treatment
• Desire of gestation in the next 6 months
• Presence of degenerating adenomyosis or fibroids
• Treatment with sexual hormones: mifepristone, aGnRH or any other medication that may interfere with fibroids.
• History of neoplasia of gynecological origin and/or existence of uterine malformations.
• Hypercalcemia or abnormal liver or kidney function is present