Efficacy of Palatinose™ Versus Sucrose on Flow Mediated Dilation in Healthy Subjects With Mild Hypertension

AFCRO-066: A Double-blinded, Randomized, Controlled, Acute, Cross-over Study to Determine the Efficacy of Palatinose™ Versus Sucrose on Flow Mediated Dilation in Healthy Subjects With Mild Hypertension

To determine the efficacy of Palatinose versus sucrose on Flow Mediated Dilation (FMD) in healthy subjects with mild hypertension.

Inclusion criteria:

• Subject is healthy at the time of pre-examination
• Subject has a BMI of 25 - 35 kg/m²
• Subject is aged 25 - 50 years at the time of pre-examination
• Signed written informed consent
• Inactive (IPAQ score <1)
• Waist to Hip ratio ≥0.90 cm for males, ≥0.85 cm for females
• High-normo/Mild hypertensive (SBP: 130-159 mmHg / DBP: 80-99 mmHg)

Exclusion criteria:

• Use of medication interfering with RAAS, such as ACE-inhibitors,
• Advanced cardio-vascular disease (CVD),
• Severe kidney disorders (CKD),
• Diabetes mellitus, both type 1 and II diabetes,
• Pregnant, lactating or wish to become pregnant,
• Hypersensitivity to any of the components of the test product,
• Restricted diet (vegetarian)
• Thyroid disease
• Heavy Smokers (light smokers allowed)
• Lack of suitability for participation in the trial, for any medical reason, as judged by the PI.
• Excessive alcohol consumption (>21 units/week for males & >14 units/week for females)