The main objective is to establish that a new technique of amyloidosis typing by Proteomics (based on nanoLC-MS/MS mass spectrometry) allows typing in > 90% of observations in patients whose Amyloidosis is reported to have failed typing (impossible typing, uncertain or inconsistent) with the traditional anatomopathological approach, and this in a cohort of 40 patients identified consecutively in the Department of pathological anatomy and cytology of the University Hospital of Toulouse and included prospectively.

Inclusion Criteria:

• Diagnosis of Amyloidosis by Red Congo staining and birefringence in polarized light on tissue sampling

• Immunolabeling Amyloidosis typing

  1. impossible (no frozen sample available)
  2. or inconclusive (doubtful)
  3. or inconsistent with clinical, biological, genetic and iconographic data

• Signature of the informed consent form

Exclusion Criteria:

• Insufficient tissue material to perform the new technique
• Person placed under judicial protection
• Pregnant and breastfeeding women