Unusual Toxicity Induced by Radiotherapy

Collection of Biological Samples for Stydy of Unusual Toxicity Induced by Radiotherapy

In order to evaluate the physiopathological knowledge of the different pathological manifestations associated with individual radiosensitivity, it seems essential to carry out this pilot study. It has agglomerated homogeneous tissue samples to identify new biomarkers for patient diagnosis and follow-up, and may predict the therapeutic response. These knowledge will help to treatment customization.

Inclusion Criteria:

• Child or teenager aged 2 to <18

• Man, Woman> 18 years old

• Patient with one of these situations:

  • Unusual toxicity in progress or after radiotherapy
  • Indication of radiotherapy and suspicion of abnormal pathways of response to ionizing radiation - constitutional (genetic disease) or acquired (systemic disease) - which may generate unusual radioinduced toxicity

• Patient information and informed consent signed by the patient. For children and teenager : information to parents and obtaining informed consent

• Affiliation to a social security scheme.

Exclusion Criteria:

• Contraindication for skin and / or tumoral biopsy
• Contraindication for blood sample of 2.5 ml
• Persons deprived of liberty or under supervision