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In order to evaluate the physiopathological knowledge of the different pathological manifestations associated with individual radiosensitivity, it seems essential to carry out this pilot study. It has agglomerated homogeneous tissue samples to identify new biomarkers for patient diagnosis and follow-up, and may predict the therapeutic response. These knowledge will help to treatment customization.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| skin and/or tumor Biopsy and blood sample | Other |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| skin biopsy | Other | skin biopsy will be taken under local anesthesia using a patch of lidocaine and prilocaine. In practice, during the skin biopsy, the skin must be cleaned with chlorhexidine or alcohol, to the exclusion of any other antiseptic. The biopsy will preferably be done with a dermatome (or "punch", 12 G). |
| Measure | Description | Time Frame |
|---|---|---|
| skin fibroblast radiosensitivity | The number of residual double strand break at 24 hours (number of 53BP1 foci) after a dose of 2 Gy will be quantified with indirect immunofluorescence | 2 to 3 months after skin biopsy |
| Measure | Description | Time Frame |
|---|---|---|
| tumor cells radiosensitivity | The number of residual double strand break at 24 hours (number of 53BP1 foci) after a dose of 2 Gy will be quantified with indirect immunofluorescence | 2 to 3 months after tumor biopsy |
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Inclusion Criteria:
Child or teenager aged 2 to <18
Man, Woman> 18 years old
Patient with one of these situations:
Patient information and informed consent signed by the patient. For children and teenager : information to parents and obtaining informed consent
Affiliation to a social security scheme.
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Institut de Cancérologie de Lorraine | Vandœuvre-lès-Nancy | 54519 | France |
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| ID | Term |
|---|---|
| D009369 | Neoplasms |
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| ID | Term |
|---|---|
| D001800 | Blood Specimen Collection |
| ID | Term |
|---|---|
| D013048 | Specimen Handling |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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|
| tumor biopsy | Other | an additional tumor sample will be taken during programmed diagnostic procedure. |
|
| blood sample | Other | blood sample will be taken for biological collection |
|
| D011677 | Punctures |
| D013514 | Surgical Procedures, Operative |
| D008919 | Investigative Techniques |