Inflammatory Responses in Solitary and Multiple Erythema Migrans

Inflammatory Responses in Borrelia Afzelii Culture Positive Patients With Early Disseminated or Early Localized Lyme Borreliosis

The investigators will evaluate differences in host immune responses (levels of cytokines and chemokines, representative of innate, Th1, and Th17 immune responses) in acute sera from adult patients with solitary or multiple erythema migrans.

Inclusion Criteria:

• erythema migrans in patients > 18 years
• Borrelia afzelii isolated from skin

Exclusion Criteria:

• pregnancy or immunocompromising conditions
• taking antibiotic with antiborrelial activity within 10 days