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Obstructive sleep apnea syndrome (OSA) is thought to lead to systemic vascular lesions that may be preceded by early microvascular lesions in the eyes and in particular in the retina. The improvement of ophthalmological imaging techniques by OCTangiography allows a precise non-invasive study of the retinal microvascular network. This new rapid and non-invasive retinal imaging tool could reveal micro-vascular lesions related to OSA. To the investigator's knowledge, this would be the first OCT-angiography description of a cohort of patients with OSA. If these results are confirmed, it would be interesting to study the correlation between these micro-vascular lesions and the cardiovascular risk of his patients.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients | Patients referred for polysomnography diagnosis of obstructive sleep apnea syndrome |
| |
| Controls | Person without obstructive sleep apnea syndrome |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| complete ophthalmological examination | Other | collection:
|
| Measure | Description | Time Frame |
|---|---|---|
| Measurement of macular and peri-papillary retinal vascular density of the superficial and deep capillary plexuses | Change from baseline at 24 months | |
| Measurement of macular and peri-papillary retinal infusion density of the superficial and deep capillary plexuses | Change from baseline at 24 months | |
| Measurement of the surface of the macular avascular zone of the superficial and deep capillary plexuses | Change from baseline at 24 months |
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Inclusion Criteria:
Patient group:
- Patient seen in sleep apnea screening consultation by a pulmonologist and referred for polysomnography diagnosis of OSA
Control Group:
- Person initially without obstructive sleep apnea syndrome
Exclusion Criteria:
Control Group:
person with a history of chronic lung problems (e.g. COPD, chronic respiratory failure, etc.)
person with at least one of the following risk factors for obstructive sleep apnea syndrome:
Exclusion criteria: positive result in one of the 3 self-questionnaires
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Patients seen for sleep apnea screening by a pulmonologist and referred for polysomnography diagnosis of obstructive sleep apnea syndrome
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Chu Dijon Bourogne | Dijon | 21000 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41638537 | Result | Germanese C, Georges M, Bonniaud P, Goueslard K, Arnould L, Creuzot Garcher C, Gabrielle PH. Characterization of Retinal Microvascular Changes in Obstructive Sleep Apnea Using OCT Angiography: Data from the Obstructive Sleep Apnea and Retinal Microvascular NETwork Study. Ophthalmology. 2026 Jun;133(6):742-754. doi: 10.1016/j.ophtha.2026.01.030. Epub 2026 Feb 2. |
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| ID | Term |
|---|---|
| D020181 | Sleep Apnea, Obstructive |
| ID | Term |
|---|---|
| D012891 | Sleep Apnea Syndromes |
| D001049 | Apnea |
| D012120 | Respiration Disorders |
| D012140 | Respiratory Tract Diseases |
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|
| D020919 |
| Sleep Disorders, Intrinsic |
| D020920 | Dyssomnias |
| D012893 | Sleep Wake Disorders |
| D009422 | Nervous System Diseases |