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| Name | Class |
|---|---|
| University of Manchester | OTHER |
| Columbia University | OTHER |
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Early glaucomatous visual field changes can be missed with the routinely used Standard Automated Perimetry (SAP) and the 24-2 test pattern due to limited sampling of the central 10 degrees. While this shortcoming can be overcome with the addition of a 10-2 test, performing both tests places extra demand on the perimetric services (doubling test times) and patients.
Smart Supra Perimetry (SSP) uses a new faster algorithm that can complete both 24-2 and 10-2 test patterns in a similar time frame to a single 24-2 SAP test. This comparative study aims to determine the sensitivity and specificity (i.e. diagnostic accuracy) of SSP in identifying early glaucomatous visual field loss. A sample of 100 patients with early/suspect glaucoma will undergo SAP 24-2 and 10-2 (SITA algorithm) using Humphrey visual field perimetry and SSP 24+10-2 using Henson 9000. Eyes will be categorised into 2 groups i.e., glaucoma and non-glaucoma, on the basis of structural changes to the disc as evaluated by the clinician. The sensitivity and specificity of the SAP and SSP tests will be established along with test duration. The size and location of defects established with both the SAP and SSP strategies will also be compared.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Non-Glaucoma Patient Arm | Experimental | All participants will complete the same assessments |
|
| Glaucoma Patient Arm | Experimental | All participants will complete the same assessments |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Humphrey Visual Field Test | Diagnostic Test | SITA Standard and 24-2 and 10-2 visual field tests |
|
| Measure | Description | Time Frame |
|---|---|---|
| Diagnostic performance of smart supra perimetry | Area under the curve for Smart Suprathrold Perimetry using probability thresholds to differentiate early glaucoma from non-glaucomatous visual fields. | 12 months |
| Measure | Description | Time Frame |
|---|---|---|
| Diagnostic performance of Optical Coherent Tomography | Sensitivity and specificity for Optical Coherent Tomography in the detection of early glaucoma. | 12 months |
| Diagnostic performance of Standard Automated perimetry |
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Inclusion Criteria:
Additional inclusion criteria for glaucomatous group:
Additional inclusion criteria non-glaucoma group:
Exclusion Criteria:
Exclusion criteria glaucomatous and control groups:
• Anomalous discs, Tilted discs, myopic discs.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Manchester Royal Eye Hospital | Manchester | M13 9WL | United Kingdom |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40366217 | Derived | Sukumar S, Harper RA, Tsamis E, Hood D, Henson DB. Diagnostic Accuracy of Smart Supra Perimetry in Comparison With Standard Automated Perimetry in the Detection of Early Glaucoma. J Glaucoma. 2025 Sep 1;34(9):710-718. doi: 10.1097/IJG.0000000000002596. Epub 2025 May 14. |
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| ID | Term |
|---|---|
| D009798 | Ocular Hypertension |
| D005901 | Glaucoma |
| ID | Term |
|---|---|
| D005128 | Eye Diseases |
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| ID | Term |
|---|---|
| D041623 | Tomography, Optical Coherence |
| D011877 | Radionuclide Imaging |
| ID | Term |
|---|---|
| D041622 | Tomography, Optical |
| D061848 | Optical Imaging |
| D003952 | Diagnostic Imaging |
| D019937 | Diagnostic Techniques and Procedures |
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All participants will have the same examinations but in a randomised order, these examinations are: Humphrey Visual Fields Test (10-2 and 24-2, SITA Standard), OCT Scan (Cube scan, Wide angle and macula scan) and Smart Perimetry - Henson 9000.
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| Optical Coherence Tomography (OCT) Scan | Diagnostic Test | Circle and Wide Angle Scans |
|
| Smart Perimetry - Henson 9000 | Diagnostic Test | 24+10-2 Smart Supra test |
|
Sensitivity and specificity for Standard Automated perimetry in the detection of early glaucoma.
| 12 months |
| D003933 | Diagnosis |
| D014054 | Tomography |
| D008919 | Investigative Techniques |
| D003947 | Diagnostic Techniques, Radioisotope |