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| Name | Class |
|---|---|
| Boehringer Ingelheim | INDUSTRY |
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The purpose of this study is to determine how interstitial lung disease can be predicted over time in early rheumatoid arthritis. The investigators will study blood and phlegm samples from participants, along with quality of life questionnaires to determine if and how the presence of ILD may impact the participants quality of life over time.
Participation involves 5 study visits over an 18 month timeframe. During each of these visits, a recent medical history and physical exam will take place, blood and phlegm will be collected, quality of life questionnaires will be administered, and a CT-scan of the chest and pulmonary function testing may be performed.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| RA with no ILD | Subjects diagnosed with RA less then 2 years and without a diagnosis of ILD, will complete 5 in-person study visits. Visits will be performed every 6 months for 18 months. Study Assessments Include:
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| RA with ILD | Patients diagnosed with RA less than 2 years, and clinically diagnosed with interstitial lung disease (ILD), will complete 5 in-person study visits. Visits will be performed every 6 months for 18 months. Study Assessments Include:
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| Measure | Description | Time Frame |
|---|---|---|
| Change in anti-CCP antibody test to identify the presence or development of RA in patients with or without ILD | 18 months | |
| Change in lung antigen targets in RA-ILD using induced sputum | 18 months | |
| Change from baseline for Leicester Cough questionnaire-Acute (LCQ_Acute) | 18 months | |
| Change from baseline for Short Form (SF_36) questionnaire | 18 months | |
| Change from baseline for UCSD Medical Center Pulmonary Rehabilitations Program Shortness-of-Breath questionnaire | 18 months | |
| Change from baseline for Multi-Dimensional Health Assessment questionnaire (MDHAQ) | 18 months |
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Inclusion Criteria:
Exclusion Criteria:
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Subjects are selected for participation in the study because they have an active diagnosis of rheumatoid arthritis and are at risk fro the development of lung disease.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Faduma Ahmed, MPH | Contact | 303-398-1285 | ahmedf@NJHealth.org | |
| Jami Henriksen | Contact | 303-398-1996 | henriksenj@njhealth.org |
| Name | Affiliation | Role |
|---|---|---|
| Joshua Solomon, MD | National Jewish Health | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| National Jewish Health | Recruiting | Denver | Colorado | 80206 | United States |
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| ID | Term |
|---|---|
| D001172 | Arthritis, Rheumatoid |
| D017563 | Lung Diseases, Interstitial |
| D011658 | Pulmonary Fibrosis |
| ID | Term |
|---|---|
| D001168 | Arthritis |
| D007592 | Joint Diseases |
| D009140 | Musculoskeletal Diseases |
| D012216 | Rheumatic Diseases |
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Serum biomarker and cell collection
| D003240 |
| Connective Tissue Diseases |
| D017437 | Skin and Connective Tissue Diseases |
| D001327 | Autoimmune Diseases |
| D007154 | Immune System Diseases |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D005355 | Fibrosis |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |