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The aim of the study is to evaluate streptococcal carriage by swab, pharyngeal, anal and perineal in patients with DHBN-FN, in the entourage living under the same roof as well as patients with erysipelas
The main hypothesis is the major role of chronic porting of patients and entourage in DHBN-FN to SBH.
Indeed, the chronic pharyngeal / anal / perineal carriage could be a gateway following a transient bacteremia for a DHBN-FN.
The transmission of germs from the surrounding to the patient plays a major role:
At the gateway level in the case of exogenous DHBN-FN At the origin of chronic carriage in the case of endogenous DHBN-FN Transmission of germs from the patient to the surrounding area also plays an important role in increasing the risk of invasive SBH infections in the surrounding area.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| DHBN-FN arm | Experimental | Recruitment is planned in traditional hospitalization for DHBN-FN patients. Evaluation of streptococcal carriage by swab, pharyngeal, anal and perineal in patients hospitalized for a DHBN-FN at the end of hospitalization and 1 month after discharge from hospital during the reassessment consultation. Swabs made by the dermatologist. The carriage of streptococcus in patients living under the same roof as patients with DHBN-FN will be evaluated by pharyngeal swab, anal and perineal. If the family accepts, the carriage of streptococcus in persons living under the same roof as patients with DHBN-FN will be evaluated by pharyngeal, anal and perineal swab in consultation. These swabs will be made within 10 days of diagnosis of DHBN-FN of the index |
|
| Control arm (Erysipelas) | Active Comparator | Recruitment is planned in traditional hospitalization for patients with erysipelas. The carriage of streptococcus in patients with erysipelas will be evaluated by pharyngeal, anal and perineal swab on day 0 (admission). |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| DHBN-FN arm | Other | DHBN-FN will be evaluated by pharyngeal swab, anal and perineal. If the family accepts, the carriage of streptococcus in persons living under the same roof as patients with DHBN-FN will be evaluated by pharyngeal, anal and perineal swab in consultation. These swabs will be made within 10 days of diagnosis of DHBN-FN of the index |
| Measure | Description | Time Frame |
|---|---|---|
| Rate of beta-hemolytic streptococcus in patients with DHBN-FN | Evaluation of streptococcal carriage by swab, pharyngeal, anal and perineal in patients hospitalized for a DHBN-FN . Swabs made by the dermatologist. The detection of beta-hemolytic streptococcus will be made by culture | Day 0 |
| Rate of beta-hemolytic streptococcus in patients with DHBN-FN | Evaluation of streptococcal carriage by swab, pharyngeal, anal and perineal in patients hospitalized for a DHBN-FN . Swabs made by the dermatologist. The detection of beta-hemolytic streptococcus will be made by culture | 1 month after hospitalization discharge |
| Rate of beta-hemolytic streptococcus in patients with DHBN-FN | Evaluation of streptococcal carriage by swab, pharyngeal, anal and perineal in patients hospitalized for a DHBN-FN . Swabs made by the dermatologist. The detection of beta-hemolytic streptococcus will be made by culture | Day 30 |
| Measure | Description | Time Frame |
|---|---|---|
| Prevalence of SBH carriage at the time of diagnosis | Day 0, Day 10 | |
| Sites of SBH carriage at the time of diagnosis | Day 0, Day 10 | |
| Rate of beta-hemolytic streptococcus in patients with erysipelas |
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Inclusion Criteria:
Case contact
Exclusion Criteria:
Case contact
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Olivier CHOSIDOW, Professor | Contact | +33(1)49812500 | olivier.chosidow@aphp.fr | |
| Camille HUA, Doctor | Contact | 01 49 87 81 72 | camille.hua@aphp.fr |
| Name | Affiliation | Role |
|---|---|---|
| Olivier CHOSODOW, Professor | Henri Mondor University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Henri Mondor Hospital-AP-HP | Créteil | 94000 | France |
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| ID | Term |
|---|---|
| D013290 | Streptococcal Infections |
| ID | Term |
|---|---|
| D016908 | Gram-Positive Bacterial Infections |
| D001424 | Bacterial Infections |
| D001423 | Bacterial Infections and Mycoses |
| D007239 | Infections |
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|
| Control arm (Erysipelas) | Other | The carriage of streptococcus in patients with erysipelas will be evaluated by pharyngeal, anal and perineal swab on day 0 (admission). |
|
The carriage of streptococcus in patients with erysipelas will be evaluated by pharyngeal, anal and perineal swab on day 0. |
| Day 0 |
| Rate of beta-hemolytic streptococcus in patients living under the same roof as patients with DHBN-FN | The carriage of streptococcus in persons living under the same roof as patients with DHBN-FN will be evaluated by pharyngeal, anal and perineal swab in consultation. These swabs will be made within 10 days of diagnosis of DHBN-FN of the index. | Up to 10 Days |
| Main factors of streptococcal virulence | Analyze the main factors of streptococcal virulence by Streptococcal genome sequencing | Day 0, Day 10 |