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To address the objectives, a retrospective cohort design will be employed to evaluate patient characteristics, treatment patterns, medication effectiveness, and health care cost and utilization in RA patients newly initiating tofacitinib in combination with oral methotrexate (MTX)
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Truven Health MarketScan Research Database | Compare treatment patterns including dosing, concomitant medication use, adherence, persistence, and switching among tofacitinb+MTX patients who withdraw MTX vs. persist with MTX or experience interrupted MTX |
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| Measure | Description | Time Frame |
|---|---|---|
| Number of Participants as Per Type of Insurance Plan | Number of participants covered by type of insurance is reported. There were two types of insurance: 1) a private insurance plan, that is, one purchased by the participants, commercially available; 2) employer-provided insurance plan, that is, the participant's employer provided the insurance. | During pre-index period (12 months duration before the index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
| Number of Participants in Each Geographic Region | Number of participants enrolled in the study per geographic region of the United States (northeast; north central; south; west; unknown) is reported. | During pre-index period (12 months duration before the index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
| Number of Participants With Biologic Disease Modifying Antirheumatic Drug (bDMARD) Use During Pre-Index Period | Number of Participants with use of at least one bDMARD during pre-index period is reported. The bDMARD could have been any tumor-necrosis factor-alpha inhibitors (TNFi), any non-TNFi, adalimumab, certolizumab pegol, etanercept, golimumab, infliximab, anakinra, abatacept, tocilizumab or rituximab. | During pre-index period (12 months duration before the index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
| Number of Participants With Biologic Disease Modifying Antirheumatic Drug (bDMARD) Use During Variable Length Pre-Index Period | Number of Participants with use of at least one bDMARD during variable length pre-index period is reported. The bDMARD could have been any TNFi, any non-TNFi, adalimumab, certolizumab pegol, etanercept, golimumab, infliximab, anakinra, abatacept, tocilizumab or rituximab. Variable-length pre-index period defined as the period from the participant's first date of enrollment in the database to the day before the index date. The date of enrollment had to be at least 1 year prior to the index date and depending on the participant, could have been as much as maximum of 5.2 years. The index date was the date of the first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years. |
| Measure | Description | Time Frame |
|---|---|---|
| Mean Total All Cause Monthly Health Care Cost | Mean total monthly health care cost due to all cause is reported. All cause refers to cost spent due to all comorbidities, including RA and calculated as the total of pharmacy cost (cost of home healthcare cost, urgent care cost and other medical services costs) and medical cost (cost of ambulatory cost, emergency department visits cost, inpatient admission cost and other costs). Total all cause monthly health care cost is reported for every month from 12 months duration before index date (pre-index period) to 12 months duration post index date (post index period). Index date is defined as the date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years. |
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Inclusion Criteria:
Exclusion Criteria:
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Individuals who are privately insured and with Medicare Supplemental insurance
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| Name | Affiliation | Role |
|---|---|---|
| Pfizer CT.gov Call Center | Pfizer | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Pfizer | New York | New York | 10017 | United States |
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| Label | URL |
|---|---|
| To obtain contact information for a study center near you, click here. | View source |
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Pfizer will provide access to individual de-identified participant data and related study documents (e.g. protocol, Statistical Analysis Plan (SAP), Clinical Study Report (CSR)) upon request from qualified researchers, and subject to certain criteria, conditions, and exceptions. Further details on Pfizer's data sharing criteria and process for requesting access can be found at: https://www.pfizer.com/science/clinical\_trials/trial\_data\_and\_results/data\_requests.
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The study was a retrospective population-based register study. Detailed data on each participant was retrieved from the Truven Health MarketScan Research Database and assessed in this study.
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| ID | Title | Description |
|---|---|---|
| FG000 | Methotrexate (MTX) + Tofacitinib: MTX Persistent | Rheumatoid arthritis (RA) diagnosed participants who were privately insured or under Medicare Supplemental insurance (from their employer), initiated tofacitinib in combination with MTX, orally, between 01 January 2014 to 31 January 2017 (identification period) with no gap of more than (>)60 days in MTX therapy (persistent) within 12 months post-index date, were included in the study and their information as per Truven Health MarketScan Research Database (from January 1, 2012 to January 2018) was assessed in this study. Index date defined as the date of first claim for tofacitinib by participants to their insurance provider during identification period. |
| FG001 | Methotrexate (MTX) + Tofacitinib: MTX Discontinued | RA diagnosed participants who were privately insured or under Medicare Supplemental insurance (from their employer), initiated tofacitinib in combination with MTX, orally, between 01 January 2014 to 31 January 2017 (identification period) with a gap of >60 days in MTX therapy (discontinued) within 12 months post-index date, were included in the study and their information as per Truven Health MarketScan Research Database (from January 1, 2012 to January 2018) was assessed in this study. Index date defined as the date of first claim for tofacitinib by participants to their insurance provider during identification period. |
| FG002 | Methotrexate (MTX) + Tofacitinib: MTX Interrupted | RA diagnosed participants who were privately insured or under Medicare Supplemental insurance (from their employer), initiated tofacitinib in combination with MTX, orally, between 01 January 2014 to 31 January 2017 (identification period) with a gap of >60 days with 1 or more subsequent prescription re-fills in MTX therapy (interrupted) within 12 months post-index date, were included in the study and their information as per Truven Health MarketScan Research Database (from January 1, 2012 to January 2018) was assessed in this study. Index date defined as the date of first claim for tofacitinib by participants to their insurance provider during identification period. |
| Title | Milestones | Reasons Not Completed | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Overall Study |
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Analysis was performed on all participants included in the study.
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| ID | Title | Description |
|---|---|---|
| BG000 | Methotrexate (MTX) + Tofacitinib: MTX Persistent | RA diagnosed participants who were privately insured or under Medicare Supplemental insurance (from their employer), initiated tofacitinib in combination with MTX, orally, between 01 January 2014 to 31 January 2017 (identification period) with no gap of >60 days in MTX therapy (persistent) within 12 months post-index date, were included in the study and their information as per Truven Health MarketScan Research Database (from January 1, 2012 to January 2018) was assessed in this study. Index date defined as the date of first claim for tofacitinib by participants to their insurance provider during identification period. |
| Units | Counts |
|---|---|
| Participants |
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| Title | Description | Population Description | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Denominator Units Selected | Denominators | Classes |
|---|---|---|---|---|---|---|---|---|---|
| Age, Continuous | Mean |
| Type | Title | Description | Population Description | Reporting Status | Anticipated Posting Date | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Time Frame | Units Analyzed | Denominator Units Selected | Arm/Group Information | Denominators | Classes | Analyses | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Primary | Number of Participants as Per Type of Insurance Plan | Number of participants covered by type of insurance is reported. There were two types of insurance: 1) a private insurance plan, that is, one purchased by the participants, commercially available; 2) employer-provided insurance plan, that is, the participant's employer provided the insurance. | Analysis was performed on all participants included in the study. | Posted | Count of Participants | Participants | During pre-index period (12 months duration before the index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
|
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Due to the nature of claims data base from which these data where queried, no adverse events were collected in this study.
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| ID | Title | Description | Deaths (Affected) | Deaths (At Risk) | Serious Events (Affected) | Serious Events (At Risk) | Other Events (Affected) | Other Events (At Risk) |
|---|---|---|---|---|---|---|---|---|
| EG000 | Methotrexate (MTX) + Tofacitinib: MTX Persistent | RA diagnosed participants who were privately insured or under Medicare Supplemental insurance (from their employer), initiated tofacitinib in combination with MTX, orally, between 01 January 2014 to 31 January 2017 (identification period) with no gap of >60 days in MTX therapy (persistent) within 12 months post-index date, were included in the study and their information as per Truven Health MarketScan Research Database (from January 1, 2012 to January 2018) was assessed in this study. Index date defined as the date of first claim for tofacitinib by participants to their insurance provider during identification period. |
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| Title | Organization | Phone | Extension | |
|---|---|---|---|---|
| Pfizer ClinicalTrials.gov Call Center | Pfizer Inc. | 1-800-718-1021 | ClinicalTrials.gov_Inquiries@pfizer.com |
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| Prot_SAP | Yes | Yes | No | Study Protocol and Statistical Analysis Plan | May 1, 2018 | Sep 28, 2019 | Prot_SAP_000.pdf |
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| ID | Term |
|---|---|
| D001172 | Arthritis, Rheumatoid |
| ID | Term |
|---|---|
| D001168 | Arthritis |
| D007592 | Joint Diseases |
| D009140 | Musculoskeletal Diseases |
| D012216 | Rheumatic Diseases |
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| During variable length pre-index period (1 year before the index date up to 5.2 years) |
| Mean Number of Biologic Disease Modifying Antirheumatic Drug (bDMARD) Received During Pre-Index Period | Mean number of bDMARD received during pre-index period is reported. The bDMARD could have been any TNFi, any non-TNFi, adalimumab, certolizumab pegol, etanercept, golimumab, infliximab, anakinra, abatacept, tocilizumab or rituximab. | During pre-index period (12 months duration before the index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
| Mean Number of Biologic Disease Modifying Antirheumatic Drug (bDMARD) Received During Variable Length Pre-Index Period | Mean number of bDMARD received during variable length pre-index period is reported. The bDMARD could have been any TNFi, any non-TNFi, adalimumab, certolizumab pegol, etanercept, golimumab, infliximab, anakinra, abatacept, tocilizumab or rituximab. Variable-length pre-index period defined as the period from the participant's first date of enrollment in the database to the day before the index date. The date of enrollment had to be at least 1 year prior to the index date and depending on the participant could have been as much as maximum of 5.2 years. The index date was the date of the first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years. | During variable length pre-index period (1 year before the index date up to 5.2 years) |
| Number of Participants With Non-biologic Disease Modifying Antirheumatic Drug (NB-DMARD) Use During Pre-Index Period | Number of Participants with NB-DMARD use during pre-index period is reported. The NB-DMARD could have been hydroxychloroquine, MTX oral, leflunomide, sulfasalazine, chloroquine, cyclosporine, thalidomide, azathioprine, cyclophosphamide, auranofin, aurothioglucose, gold sodium thiomalate, penicillamine, tacrolimus or minocycline. | During pre-index period (12 months duration before the index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
| Number of Participants With Non-Biologic Disease Modifying Antirheumatic Drug (NB-DMARD) Use During Variable Length Pre-Index Period | Number of Participants with NB-MARD use during variable length pre-index period is reported. The NB-DMARD could have been hydroxychloroquine, MTX oral, leflunomide, sulfasalazine, chloroquine, cyclosporine, thalidomide, azathioprine, cyclophosphamide, auranofin, aurothioglucose, gold sodium thiomalate, penicillamine, tacrolimus or minocycline. Variable-length pre-index period defined as the period from the participant's first date of enrollment in the database to the day before the index date. The date of enrollment had to be at least 1 year prior to the index date and depending on the participant could have been as much as maximum of 5.2 years. The index date was the date of the first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years. | During variable length pre-index period (1 year before the index date up to 5.2 years) |
| Mean Number of Non-Biologic Disease Modifying Antirheumatic Drug (NB-DMARD) Received During Pre-Index Period | Mean number of NB-DMARD received during pre-index period is reported. The NB-DMARD could have been hydroxychloroquine, MTX oral, leflunomide, sulfasalazine, chloroquine, cyclosporine, thalidomide, azathioprine, cyclophosphamide, auranofin, aurothioglucose, gold sodium thiomalate, penicillamine, tacrolimus or minocycline. | During pre-index period (12 months duration before the index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
| Mean Number of Non-Biologic Disease Modifying Antirheumatic Drug (NB-DMARD) Received During Variable Length Pre-Index Period | Mean number of NB-DMARD received during variable length pre-index period is reported. The NB-DMARD could have been hydroxychloroquine, MTX oral, leflunomide, sulfasalazine, chloroquine, cyclosporine, thalidomide, azathioprine, cyclophosphamide, auranofin, aurothioglucose, gold sodium thiomalate, penicillamine, tacrolimus or minocycline. Variable-length pre-index period defined as the period from the participant's first date of enrollment in the database to the day before the index date. The date of enrollment had to be at least 1 year prior to the index date and depending on the participant could have been as much as maximum of 5.2 years. The index date was the date of the first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years. | During variable length pre-index period (1 year before the index date up to 5.2 years) |
| Mean Quan-Charlson Comorbidity Score of Participants | The mean Quan-Charlson Comorbidity Score during the Pre-Index Period is reported. Quan-Charlson Comorbidity Score predicts the probability of death within one year in participants and was based on the presence of any diagnosis codes on medical claims at any time during the 12-month pre-index period, based on the International Classification of Diseases (ICD) diagnosis codes. Total score ranges from 0 to 9.0. A score of zero indicates that no comorbidities were found. The higher the score, the more likely the predicted outcome could result in mortality or higher healthcare resource utilization. | During pre-index period (12 months duration before the index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
| Number of Participants With Top 25 Comorbid Conditions as Per Agency for Healthcare Research and Quality (AHRQ) During Pre-Index Period | Top 25 comorbid conditions: 1) rheumatoid arthritis/related disease, 2)other aftercare, 3)other connective tissue disease, 4)other non-traumatic joint disorders, 5)medical examination/evaluation, 6) other suspected conditions(other miscellaneous conditions other than mental disorders/infectious disease), 7)immunizations/screening for infectious disease, 8)osteoarthritis, 9)essential hypertension, 10) residual codes: unclassified, 11)disorders of lipid metabolism, 12)back problems, 13)other upper respiratory infections, 14)other lower respiratory disease, 15)other nervous system disorders, 16)other skin disorders, 17)thyroid disorders, 18)other bone disease/musculoskeletal deformities, 19) malaise/fatigue, 20)esophageal disorders, 21)nutritional deficiencies, 22)other nutritional: endocrine, metabolic disorders, 23)diabetes mellitus without complication, 24)other/unspecified benign neoplasm, 25)genitourinary symptoms/ill-defined conditions. A participant could have had >=1 comorbidity. | During pre-index period (12 months duration before the index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
| Number of Participants With Top 25 Comorbid Conditions as Per Agency for Healthcare Research and Quality (AHRQ) During Post-Index Period | Top 25 comorbid conditions: 1) rheumatoid arthritis/related disease, 2)other aftercare, 3)other connective tissue disease, 4)other non-traumatic joint disorders, 5)medical examination/evaluation, 6) other suspected conditions(other miscellaneous conditions other than mental disorders/infectious disease), 7)immunizations/screening for infectious disease, 8)osteoarthritis, 9)essential hypertension, 10) residual codes: unclassified, 11)disorders of lipid metabolism, 12)back problems, 13)other upper respiratory infections, 14)other lower respiratory disease, 15)other nervous system disorders, 16)other skin disorders, 17)thyroid disorders, 18)other bone disease/musculoskeletal deformities, 19) malaise/fatigue, 20)esophageal disorders, 21)nutritional deficiencies, 22)other nutritional: endocrine, metabolic disorders, 23)diabetes mellitus without complication, 24)other/unspecified benign neoplasm, 25)Other upper respiratory disease. A participant could have had >=1 comorbidity. | During post-index period (12 months duration post index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
| Mean Claims Based Index of RA Severity (CIRAS) Score During Pre-Index Period | The mean of the CIRAS score during pre-index period is reported. The CIRAS is based on claims at any time during the 12-month pre-index period, used to measure RA disease severity using 9 measures (age at index, gender, inflammatory marker test ordered, rehabilitation visit, rheumatoid factor test, Felty's syndrome, number of platelet counts ordered, number of chemistry panels ordered, rheumatologist visit). Value of all 9 measure was used to derive the overall CIRAS score which ranges from 0-7.9 with higher value indicating greater severity of RA. | During pre-index period (12 months duration before the index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
| Number of Participants With 25 Most Common Medications Use During Pre-Index Period | Number of participants with 25 most common medications use during the pre-index period are reported. The 25 most medications: 1) MTX sodium, 2) folic acid, 3) prednisone, 4) acetaminophen/hydrocodone bitartrate, 5) azithromycin, 6) adalimumab, 7) hydroxychloroquine sulfate, 8) etanercept, 9) levothyroxine sodium, 10) methylprednisolone, 11) omeprazole, 12) tramadol hydrochloride, 13) meloxicam, 14) amoxicillin, 15) albuterol sulfate, 16) gabapentin, 17) acetaminophen/oxycodone hydrochloride, 18) amoxicillin/clavulanate potassium, 19) cyclobenzaprine hydrochloride, 20) fluticasone propionate, 21) ciprofloxacin hydrochloride, 22) duloxetine hydrochloride, 23) atorvastatin calcium, 24) diclofenac sodium, 25) levofloxacin. A participant could have received >=1 most common medication. | During pre-index period (12 months duration before the index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
| Number of Participants With 26 Most Common Medications Use During Post-Index Period | Number of participants with 26 most common medications use during the post-index period are reported. The 26 most common medications: 1) MTX sodium, 2) folic acid, 3) prednisone, 4) acetaminophen/hydrocodone bitartrate, 5) azithromycin, 6) adalimumab, 7) hydroxychloroquine sulfate, 8) etanercept, 9) levothyroxine sodium, 10) methylprednisolone, 11) omeprazole, 12) tramadol hydrochloride, 13) meloxicam, 14) amoxicillin, 15) albuterol sulfate, 16) gabapentin, 17) acetaminophen/oxycodone hydrochloride, 18) amoxicillin/clavulanate potassium, 19) cyclobenzaprine hydrochloride, 20) fluticasone propionate, 21) ciprofloxacin hydrochloride, 22) duloxetine hydrochloride, 23) diclofenac Sodium, 24) levofloxacin, 25) cephalexin, 26) ibuprofen. A participant could have received >=1 most common medication. | During post-index period (12 months duration post index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
| Number of Participants Who Used Opioids During Pre-Index Period | Number of participants who used at least one opioid during pre-index period are reported. | During pre-index period (12 months duration before the index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
| Number of Participants Who Used Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) During Pre-Index Period | Number of participants who used at least one NSAID during pre-index period are reported. | During pre-index period (12 months duration before the index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
| Number of Participants Who Used Opioids During Post-Index Period | Number of participants who used at least one opioid during the post-index period are reported. | During post-index period (12 months duration post index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
| Number of Participants Who Used NSAIDs During Post-Index Period | Number of participants who used at least one NSAID during the post-index period are reported. | During post-index period (12 months duration post index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
| Mean Number of Pharmacy Claims for Opioids During Pre-Index Period | The mean number of pharmacy claims for opioids during the pre-index period are reported. A pharmacy claim is defined as a claim made by participants to their insurance provider in purchasing opioids from their pharmacy. | During pre-index period (12 months duration before the index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
| Mean Number of Pharmacy Claims for Non-Steroidal Anti Inflammatory Drugs (NSAIDs) During Pre-Index Period | The mean number of pharmacy claims for NSAIDs during the pre-index period are reported. A pharmacy claim is defined as a claim made by participants to their insurance provider in purchasing NSAIDs from their pharmacy. | During pre-index period (12 months duration before the index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
| Mean Number of Pharmacy Claims for Opioids During Post-Index Period | The mean number of pharmacy claims for opioids during the post-index period are reported. A pharmacy claim is defined as a claim made by participants to their insurance provider in purchasing opioids from their pharmacy. | During post-index period (12 months duration post index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
| Mean Number of Pharmacy Claims for Non-Steroidal Anti Inflammatory Drugs (NSAIDs) During Post-Index Period | The mean number of pharmacy claims for NSAIDs during the post-index period are reported. A pharmacy claim is defined as a claim made by participants to their insurance provider in purchasing NSAIDs from their pharmacy. | During post-index period (12 months duration post index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
| Mean Number of Days From The Index Date to The First Opioid Claim During Post Index Period | Mean number of days from the index date to the first opioid claim during post index period are reported. | During post-index period (12 months duration post index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
| Mean Number of Days From The Index Date to The First NSAIDs Claim During Post Index Period | Mean number of days from the index date to the first NSAIDs claim during post index period are reported. | During post-index period (12 months duration post index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
| Number of Participants Who Used Opioids During Tofacitinib Persistency and Post-Persistency | Number of participants who used opioids during tofacitinib persistency and post-persistency are reported. Persistence for participants is defined as the period of treatment with tofacitinib. Post persistence refers to switching to another medication from tofacitinib; or discontinuing tofacitinib either permanently or for a gap in time >60 days before restarting. | During post-index period (12 months duration post index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
| Number of Participants Who Used NSAIDs During Tofacitinib Persistency and Post-Persistency | Number of participants who used NSAIDs during tofacitinib persistency and post-persistency are reported. Persistence for participants is defined as the period of treatment with tofacitinib. Post persistence refers to switching to another medication from tofacitinib; or discontinuing tofacitinib either permanently or for a gap in time >60 days before restarting. | During post-index period (12 months duration post index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
| Number of Participants Who Used Oral Corticosteroids During Pre-Index Period | The number of participants who used at least one oral corticosteroid during the pre-index period is reported. | During pre-index period (12 months duration before the index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
| Number of Participants Who Used Oral Corticosteroids During Post-Index Period | The number of participants who used at least one oral corticosteroid during the post-index period is reported. | During post-index period (12 months duration post index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
| Mean Total Dose of Oral Corticosteroids During Pre-Index Period | Mean total dose of oral corticosteroids during pre-index period is reported. The total dose is expressed as a prednisone-equivalent dose of the oral corticosteroids used. | During pre-index period (12 months duration before the index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
| Mean Total Dose of Oral Corticosteroid During Post-Index Period | Mean total dose of oral corticosteroids during post-index period is reported. The total dose is expressed as a prednisone-equivalent dose of the oral corticosteroids used. | During post-index period (12 months duration post index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
| Mean Number of Visits to Rheumatologist During Pre-Index Period | Mean number of visits to a rheumatologist during pre-index period is reported. A visit is referring to out-patient visit specifically to a rheumatologist. | During pre-index period (12 months duration before the index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
| Mean Number of Visits to Rheumatologist During Variable-Length Pre-Index Period | Mean number of visits to rheumatologist during the variable-length pre-index period is reported. A visit is referring to out-patient visit specifically to a rheumatologist. Variable-length pre-index period defined as the period from the participant's first date of enrollment in the database to the day before the index date. The date of enrollment had to be at least 1 year prior to the index date and depending on the participant could have been as much as maximum of 5.2 years. The index date was the date of the first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years. | During variable length pre-index period (1 year before the index date up to 5.2 years) |
| Mean Disease Duration | Mean Disease Duration of RA based upon the variable length pre-index period is reported. Disease duration (in days) defined as the number of days from the earliest claim with a diagnosis of RA in the variable length pre-index period until the index date. Variable-length pre-index period defined as the period from the participant's first date of enrollment in the database to the day before the index date. The date of enrollment had to be at least 1 year prior to the index date and depending on the participant could have been as much as maximum of 5.2 years. The index date was the date of the first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years. | During variable length pre-index period (1 year before the index date up to 5.2 years) |
| Mean Out of Pocket Health Care Costs for Healthcare Services During Pre-Index Period | Mean out of pocket health care costs for healthcare services during pre-index period is reported. It is categorized as: All causes and RA related. All cause consisted of money spent by participants on all health care services (pharmacy, medical [ambulatory, emergency department and inpatient admission]). RA related signifies money spent by participants on health care services for RA. | During pre-index period (12 months duration before the index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
| Mean Out of Pocket Health Care Costs for Healthcare Services During Variable Length Pre-Index Period | Mean out of pocket health care costs for healthcare services during variable length pre-index period is reported. It is categorized as: All causes and RA related. All cause consisted of money spent by participants on all health care services (pharmacy, medical [ambulatory, emergency department and inpatient admission]). RA related signifies one spent by participants on health care services for RA. Variable-length pre-index period defined as the period from the participant's first date of enrollment in the database to the day before the index date. The date of enrollment had to be at least 1 year prior to the index date and depending on the participant could have been as much as maximum of 5.2 years. The index date was the date of the first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years. | During variable length pre-index period (1 year before the index date up to 5.2 years) |
| Number of Participants With Comorbidities of Interest During Pre-Index Period | Number of participants with at least one of comorbidity of interest during pre-index period is reported. The comorbidities of interest included cardiovascular diseases, chronic obstructive pulmonary disorder (COPD), asthma, kidney disease, diabetes, depression, anxiety, liver disease, sleep disorders. A participant could have >1 comorbidity of interest. | During pre-index period (12 months duration before the index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
| Number of Participants With Non-persistence to Index Medication (Tofacitinib) | Non-persistence was defined as the gap of at least 60 days in treatment with the index medication (tofacitinib) or switching to other biologic. | During post-index period (12 months duration post index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
| Number of Participants With Post-Persistence Treatment Patterns | Number of participants with post-persistence treatment patterns is reported. Post-persistence was categorized as: 1) switch immediately (if participants initiated a non-index biologic before a 60-day gap in treatment is observed for the index medication); 2) discontinue then restart (if there was a gap in the index therapy of at least 60 days and the first medication observed after the gap is the index medication); 3) discontinue then switch ( if there was a gap in the index therapy of at least 60 days and the first medication observed after the gap is a biologic [including Tofacitinib] different from index medication), 4) discontinue without switch or restart (if participant's had a gap in therapy of at least 60 days and there are no claims for either the index medication or a different biologic for the remaining observation period). | During post-index period (12 months duration post index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
| Number of Participants Who Switched From Index Medication (Tofacitinib) at Any Time During Post-Index Period | Number of participants who switched from index medication (tofacitinib) to a biologic at any time during post-index period is reported. | During post-index period (12 months duration post index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
| Number of Participants Who Re-started Index Medication (Tofacitinib) at Any Time During Post-Index Period | Number of participants who re-started tofacitinib (after considered as non-persistence with the tofacitinib) after discontinuation at any time during post-index period is reported. | During post-index period (12 months duration post index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
| Mean Medication Possession Ratio (MPR) for Methotrexate (MTX) | Mean MPR for Methotrexate is reported. MPR was calculated as the total days supply of MTX between the first and including the last prescription/administration divided by the time between the first through and including last biologic prescription/administration days supply. | During post-index period (12 months duration post index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
| Mean Adherence To Methotrexate (MTX) | Mean adherence for methotrexate is reported. Adherence was calculated as the total number of days supplied for MTX during the post-index period divided by the number of days from the first claim during the post-index period to the end of the post-index period | During post-index period (12 months duration post index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
| Number of Participants Who Used Additional NB-DMARD During Post Index Period | Number of participants who used additional NB-DMARD during post index period is reported. Additional NB-DMARD use could have been leflunomide, sulfasalazine and hydroxychloroquine. | During post-index period (12 months duration post index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
| Number of Participants Who Met Medication Effectiveness Criteria: Adherence to Index Medication (Tofacitinib) | Medication effectiveness criteria categorized as: 1) adherence to index medication, 2) no dose escalation for index medication, 3) no switch from index medication, 4) no addition of NB-DMARD, 5) criteria for oral glucocorticoids, 6) use of Injectable glucocorticoids. Adherence to index medication was defined as at least 30 days continuous supply of tofacitinib during post-index period. | During post-index period (12 months duration post index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
| Number of Participants Who Met Medication Effectiveness Criteria: No Dose Escalation for Index Medication (Tofacitinib) | Medication effectiveness criteria categorized as: 1) adherence to index medication, 2) no dose escalation for index medication, 3) no switch from index medication, 4) no addition of NB-DMARD, 5) criteria for oral glucocorticoids, 6) use of Injectable glucocorticoids. No dose escalation for index medication was defined as no increase in dose for index medication compared to the starting dose during post-index period. | During post-index period (12 months duration post index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
| Number of Participants Who Met Medication Effectiveness Criteria: No Switch From Index Medication (Tofacitinib) | Medication effectiveness criteria categorized as: 1) adherence to index medication, 2) no dose escalation for index medication, 3) no switch from index medication, 4) no addition of NB-DMARD, 5) criteria for oral glucocorticoids, 6) use of Injectable glucocorticoids. No switch from index medication was defined as no switching from the index medication to a (different) biologic agent during post-index period. | During post-index period (12 months duration post index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
| Number of Participants Who Met Medication Effectiveness Criteria: No Addition of NB-DMARD | Medication effectiveness criteria categorized as: 1) adherence to index medication, 2) no dose escalation for index medication, 3) no switch from index medication, 4) no addition of NB-DMARD, 5) criteria for oral glucocorticoids, 6) use of Injectable glucocorticoids. No addition of NB-DMARD was defined as no addition of new NB-DMARD to index therapy during post-index period. | During post-index period (12 months duration post index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
| Number of Participants Who Met Medication Effectiveness Criteria: Criteria for Oral Glucocorticoids | Medication effectiveness criteria categorized as: 1) adherence to index medication, 2) no dose escalation for index medication, 3) no switch from index medication, 4) no addition of NB-DMARD, 5) criteria for oral glucocorticoids, 6) use of Injectable glucocorticoids. Medication effectiveness criteria for oral glucocorticoids was defined as either of the following: 1) Participants cannot receive oral glucocorticoids for > 30 days between (index date +91 days) to (index date + 359 days); 2) No increase in oral glucocorticoid dose during months 6-12 after index date. | During post-index period (12 months duration post index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
| Number of Participants Who Met Medication Effectiveness Criteria: Use of Injectable Glucocorticoids | Medication effectiveness criteria categorized as: 1) adherence to index medication, 2) no dose escalation for index medication, 3) no switch from index medication, 4) no addition of NB-DMARD, 5) criteria for oral glucocorticoids, 6) use of Injectable glucocorticoids. Use of Injectable glucocorticoids was defined as maximum one parenteral or intra-articular glucocorticoid joint injection use after the participant had been on biologic treatment for >3 months post index date ([index date +91 days] to [index date +359 days]). | During post-index period (12 months duration post index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
| Number of Participants With All Cause Ambulatory Visits During Pre-Index Period | Number of participants with at least one ambulatory visit that was due to all cause during the pre-index period is reported. All cause refers to ambulatory visits due to all comorbidities, including RA. | During pre-index period (12 months duration before the index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
| Number of Participants With All Cause Emergency Department Visits During Pre-Index Period | Number of participants with at least one emergency department visits that was due to all cause during the pre-index period is reported. All cause refers to emergency visits due to all comorbidities, including RA. | During pre-index period (12 months duration before the index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
| Number of Participants With All Cause Inpatient Admissions During Pre-Index Period | Number of participants with at least one inpatient admissions that was due to all cause during the pre-index period is reported. All cause refers to inpatient admission due to all comorbidities, including RA. | During pre-index period (12 months duration before the index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
| Number of Participants With RA Related Ambulatory Visits During Pre-Index Period | Number of participants with at least one ambulatory visit that was due to RA during the pre-index period is reported. RA related refers to ambulatory visits due to RA. | During pre-index period (12 months duration before the index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
| Number of Participants With RA Related Emergency Department Visits During Pre-Index Period | Number of participants with at least one emergency department visits that was due to RA during the pre-index period is reported. RA related refers to emergency department visits due to RA. | During pre-index period (12 months duration before the index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
| Number of Participants With RA Related Inpatient Admissions During Pre-Index Period | Number of participants with at least one inpatient admissions that was due to RA during the pre-index period is reported. RA related refers to inpatient admission due to RA. | During pre-index period (12 months duration before the index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
| Number of Participants With All Cause Ambulatory Visits During Post-Index Period | Number of participants with at least one ambulatory visit that was due to all cause during the post-index period is reported. All cause refers to ambulatory visits due to all comorbidities, including RA. | During post-index period (12 months duration post index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
| Number of Participants With All Cause Emergency Department Visits During Post-Index Period | Number of participants with at least one emergency department visits that was due to all cause during the post-index period is reported. All cause refers to emergency department visits due to all comorbidities, including RA. | During post-index period (12 months duration post index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
| Number of Participants With All Cause Inpatient Admissions During Post-Index Period | Number of participants with at least one inpatient admissions that was due to all cause during the post-index period is reported. All cause refers to inpatient admissions due to all comorbidities, including RA. | During post-index period (12 months duration post index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
| Number of Participants With RA Related Ambulatory Visits During Post Index Period | Number of participants with at least one of the RA-related ambulatory visits during the post-index period is reported. RA related refers to ambulatory visits due to RA. | During post-index period (12 months duration post index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
| Number of Participants With RA Related Emergency Department Visits During Post Index Period | Number of participants with at least one of the RA-related emergency department visit during the post-index period is reported. RA related refers to emergency department visits due to RA. | During post-index period (12 months duration post index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
| Number of Participants With RA Related Inpatient Admissions During Post Index Period | Number of participants with at least one of an RA-related inpatient admission during the post-index period is reported. RA related refers to inpatient admissions due to RA. | During post-index period (12 months duration post index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
| Mean Total Health Care Cost All Cause During Pre-Index Period | Mean total health care cost all cause during pre-index period is reported. All cause refers to cost spent due to all comorbidities including RA and calculated as the total of pharmacy cost (home healthcare cost, urgent care cost and other medical services costs) and medical cost (ambulatory cost, emergency department visits cost, inpatient admission cost and other costs). | During pre-index period (12 months duration before the index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
| Mean Total Health Care Cost RA Related During Pre-Index Period | RA related healthcare cost refers to cost spent due to RA alone and was calculated as the total of treatment cost (cost of tofacitinib, biologic DMARDs, NB-DMARDs and administration of intravenous (IV) biologics) and medical cost (cost of ambulatory cost, emergency department visits cost, inpatient admission cost, home health care cost, urgent care cost and other medical services cost). | During pre-index period (12 months duration before the index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
| Mean Total Health Care Cost Due to All Cause During Post-Index Period | Mean total health care cost due to all cause during post-index period is reported. All cause refers to cost spent due to all comorbidities, including RA and calculated as the total of pharmacy cost (cost of home healthcare cost, urgent care cost and other medical services costs) and medical cost (cost of ambulatory cost, emergency department visits cost, inpatient admission cost and other costs). | During post-index period (12 months duration post index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
| Mean Total Health Care Cost RA Related During Post-Index Period | RA related healthcare cost refers to cost spent due to RA alone and was calculated as the total of treatment cost (cost of tofacitinib, biologic DMARDs, NB-DMARDs and administration of IV biologics) and medical cost (ambulatory cost, emergency department visits cost, inpatient admission cost, home health care cost, urgent care cost and other medical services cost). | During post-index period (12 months duration post index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
| Mean Treatment Persistence Duration Measured for Index Medication (Tofacitinib) | Treatment persistence with tofacitinib was defined as not having a gap in therapy of at least 60 days between prescription re-fills of tofacitinib. | During post-index period (12 months duration post index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
| During pre-index period (at 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 and 12 months before index date) and post index period (at 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 and 12 month post index date) |
| Mean Total RA Related Monthly Health Care Cost | Mean total monthly health care cost due to RA is reported. RA related refers to cost spent by participants due to RA on health care services. This is calculated as the total of treatment cost (cost of tofacitinib, biologic DMARDs, NB-DMARDs and administration of IV biologics) and medical cost (ambulatory cost, emergency department visits cost, inpatient admission cost, home health care cost, urgent care cost and other medical services cost). RA related monthly health care cost is reported for every month from 12 months duration before index date (pre-index period) to 12 months duration post index date (post index period). Index date is defined as the date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years. | During pre-index period (at1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 and 12 months before index date) and post index period (at 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 and 12 month after index date) |
| BG001 | Methotrexate (MTX) + Tofacitinib: MTX Discontinued | RA diagnosed participants who were privately insured or under Medicare Supplemental insurance (from their employer), initiated tofacitinib in combination with MTX, orally, between 01 January 2014 to 31 January 2017 (identification period) with a gap of >60 days in MTX therapy (discontinued) within 12 months post-index date, were included in the study and their information as per Truven Health MarketScan Research Database (from January 1, 2012 to January 2018) was assessed in this study. Index date defined as the date of first claim for tofacitinib by participants to their insurance provider during identification period. |
| BG002 | Methotrexate (MTX) + Tofacitinib: MTX Interrupted | RA diagnosed participants who were privately insured or under Medicare Supplemental insurance (from their employer), initiated tofacitinib in combination with MTX, orally, between 01 January 2014 to 31 January 2017 (identification period) with a gap of >60 days with 1 or more subsequent prescription re-fills in MTX therapy (interrupted) within 12 months post-index date, were included in the study and their information as per Truven Health MarketScan Research Database (from January 1, 2012 to January 2018) was assessed in this study. Index date defined as the date of first claim for tofacitinib by participants to their insurance provider during identification period. |
| BG003 | Total | Total of all reporting groups |
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| Sex: Female, Male | Count of Participants | Participants |
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| Race and Ethnicity Not Collected | Race and Ethnicity were not collected from any participant. | Count of Participants | Participants |
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| OG001 | Methotrexate (MTX) + Tofacitinib: MTX Discontinued | RA diagnosed participants who were privately insured or under Medicare Supplemental insurance (from their employer), initiated tofacitinib in combination with MTX, orally, between 01 January 2014 to 31 January 2017 (identification period) with a gap of >60 days in MTX therapy (discontinued) within 12 months post-index date, were included in the study and their information as per Truven Health MarketScan Research Database (from January 1, 2012 to January 2018) was assessed in this study. Index date defined as the date of first claim for tofacitinib by participants to their insurance provider during identification period. |
| OG002 | Methotrexate (MTX) + Tofacitinib: MTX Interrupted | RA diagnosed participants who were privately insured or under Medicare Supplemental insurance (from their employer), initiated tofacitinib in combination with MTX, orally, between 01 January 2014 to 31 January 2017 (identification period) with a gap of >60 days with 1 or more subsequent prescription re-fills in MTX therapy (interrupted) within 12 months post-index date, were included in the study and their information as per Truven Health MarketScan Research Database (from January 1, 2012 to January 2018) was assessed in this study. Index date defined as the date of first claim for tofacitinib by participants to their insurance provider during identification period. |
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| Primary | Number of Participants in Each Geographic Region | Number of participants enrolled in the study per geographic region of the United States (northeast; north central; south; west; unknown) is reported. | Analysis was performed on all participants included in the study. | Posted | Count of Participants | Participants | During pre-index period (12 months duration before the index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
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| Primary | Number of Participants With Biologic Disease Modifying Antirheumatic Drug (bDMARD) Use During Pre-Index Period | Number of Participants with use of at least one bDMARD during pre-index period is reported. The bDMARD could have been any tumor-necrosis factor-alpha inhibitors (TNFi), any non-TNFi, adalimumab, certolizumab pegol, etanercept, golimumab, infliximab, anakinra, abatacept, tocilizumab or rituximab. | Analysis was performed on all participants included in the study. | Posted | Count of Participants | Participants | During pre-index period (12 months duration before the index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
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| Primary | Number of Participants With Biologic Disease Modifying Antirheumatic Drug (bDMARD) Use During Variable Length Pre-Index Period | Number of Participants with use of at least one bDMARD during variable length pre-index period is reported. The bDMARD could have been any TNFi, any non-TNFi, adalimumab, certolizumab pegol, etanercept, golimumab, infliximab, anakinra, abatacept, tocilizumab or rituximab. Variable-length pre-index period defined as the period from the participant's first date of enrollment in the database to the day before the index date. The date of enrollment had to be at least 1 year prior to the index date and depending on the participant, could have been as much as maximum of 5.2 years. The index date was the date of the first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years. | Analysis was performed on all participants included in the study. | Posted | Count of Participants | Participants | During variable length pre-index period (1 year before the index date up to 5.2 years) |
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| Primary | Mean Number of Biologic Disease Modifying Antirheumatic Drug (bDMARD) Received During Pre-Index Period | Mean number of bDMARD received during pre-index period is reported. The bDMARD could have been any TNFi, any non-TNFi, adalimumab, certolizumab pegol, etanercept, golimumab, infliximab, anakinra, abatacept, tocilizumab or rituximab. | Analysis was performed on all participants included in the study. Here, "overall number of participants analyzed" signifies participants evaluable for this outcome measure. | Posted | Mean | Standard Deviation | bDMARD | During pre-index period (12 months duration before the index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
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| Primary | Mean Number of Biologic Disease Modifying Antirheumatic Drug (bDMARD) Received During Variable Length Pre-Index Period | Mean number of bDMARD received during variable length pre-index period is reported. The bDMARD could have been any TNFi, any non-TNFi, adalimumab, certolizumab pegol, etanercept, golimumab, infliximab, anakinra, abatacept, tocilizumab or rituximab. Variable-length pre-index period defined as the period from the participant's first date of enrollment in the database to the day before the index date. The date of enrollment had to be at least 1 year prior to the index date and depending on the participant could have been as much as maximum of 5.2 years. The index date was the date of the first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years. | Analysis was performed on all participants included in the study. Here, "overall number of participants analyzed" signifies participants evaluable for this outcome measure. | Posted | Mean | Standard Deviation | bDMARD | During variable length pre-index period (1 year before the index date up to 5.2 years) |
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| Primary | Number of Participants With Non-biologic Disease Modifying Antirheumatic Drug (NB-DMARD) Use During Pre-Index Period | Number of Participants with NB-DMARD use during pre-index period is reported. The NB-DMARD could have been hydroxychloroquine, MTX oral, leflunomide, sulfasalazine, chloroquine, cyclosporine, thalidomide, azathioprine, cyclophosphamide, auranofin, aurothioglucose, gold sodium thiomalate, penicillamine, tacrolimus or minocycline. | Analysis was performed on all participants included in the study. | Posted | Count of Participants | Participants | During pre-index period (12 months duration before the index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
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| Primary | Number of Participants With Non-Biologic Disease Modifying Antirheumatic Drug (NB-DMARD) Use During Variable Length Pre-Index Period | Number of Participants with NB-MARD use during variable length pre-index period is reported. The NB-DMARD could have been hydroxychloroquine, MTX oral, leflunomide, sulfasalazine, chloroquine, cyclosporine, thalidomide, azathioprine, cyclophosphamide, auranofin, aurothioglucose, gold sodium thiomalate, penicillamine, tacrolimus or minocycline. Variable-length pre-index period defined as the period from the participant's first date of enrollment in the database to the day before the index date. The date of enrollment had to be at least 1 year prior to the index date and depending on the participant could have been as much as maximum of 5.2 years. The index date was the date of the first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years. | Analysis was performed on all participants included in the study. p-value could not be calculated for reporting groups with 100% response. | Posted | Count of Participants | Participants | During variable length pre-index period (1 year before the index date up to 5.2 years) |
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| Primary | Mean Number of Non-Biologic Disease Modifying Antirheumatic Drug (NB-DMARD) Received During Pre-Index Period | Mean number of NB-DMARD received during pre-index period is reported. The NB-DMARD could have been hydroxychloroquine, MTX oral, leflunomide, sulfasalazine, chloroquine, cyclosporine, thalidomide, azathioprine, cyclophosphamide, auranofin, aurothioglucose, gold sodium thiomalate, penicillamine, tacrolimus or minocycline. | Analysis was performed on all participants included in the study. Here, "overall number of participants analyzed" signifies participants evaluable for this outcome measure. | Posted | Mean | Standard Deviation | NB-DMARD | During pre-index period (12 months duration before the index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
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| Primary | Mean Number of Non-Biologic Disease Modifying Antirheumatic Drug (NB-DMARD) Received During Variable Length Pre-Index Period | Mean number of NB-DMARD received during variable length pre-index period is reported. The NB-DMARD could have been hydroxychloroquine, MTX oral, leflunomide, sulfasalazine, chloroquine, cyclosporine, thalidomide, azathioprine, cyclophosphamide, auranofin, aurothioglucose, gold sodium thiomalate, penicillamine, tacrolimus or minocycline. Variable-length pre-index period defined as the period from the participant's first date of enrollment in the database to the day before the index date. The date of enrollment had to be at least 1 year prior to the index date and depending on the participant could have been as much as maximum of 5.2 years. The index date was the date of the first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years. | Analysis was performed on all participants included in the study. Here, "overall number of participants analyzed" signifies participants evaluable for this outcome measure. | Posted | Mean | Standard Deviation | NB-DMARD | During variable length pre-index period (1 year before the index date up to 5.2 years) |
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| Primary | Mean Quan-Charlson Comorbidity Score of Participants | The mean Quan-Charlson Comorbidity Score during the Pre-Index Period is reported. Quan-Charlson Comorbidity Score predicts the probability of death within one year in participants and was based on the presence of any diagnosis codes on medical claims at any time during the 12-month pre-index period, based on the International Classification of Diseases (ICD) diagnosis codes. Total score ranges from 0 to 9.0. A score of zero indicates that no comorbidities were found. The higher the score, the more likely the predicted outcome could result in mortality or higher healthcare resource utilization. | Analysis was performed on all participants included in the study. | Posted | Mean | Standard Deviation | score on a scale | During pre-index period (12 months duration before the index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
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| Primary | Number of Participants With Top 25 Comorbid Conditions as Per Agency for Healthcare Research and Quality (AHRQ) During Pre-Index Period | Top 25 comorbid conditions: 1) rheumatoid arthritis/related disease, 2)other aftercare, 3)other connective tissue disease, 4)other non-traumatic joint disorders, 5)medical examination/evaluation, 6) other suspected conditions(other miscellaneous conditions other than mental disorders/infectious disease), 7)immunizations/screening for infectious disease, 8)osteoarthritis, 9)essential hypertension, 10) residual codes: unclassified, 11)disorders of lipid metabolism, 12)back problems, 13)other upper respiratory infections, 14)other lower respiratory disease, 15)other nervous system disorders, 16)other skin disorders, 17)thyroid disorders, 18)other bone disease/musculoskeletal deformities, 19) malaise/fatigue, 20)esophageal disorders, 21)nutritional deficiencies, 22)other nutritional: endocrine, metabolic disorders, 23)diabetes mellitus without complication, 24)other/unspecified benign neoplasm, 25)genitourinary symptoms/ill-defined conditions. A participant could have had >=1 comorbidity. | Analysis was performed on all participants included in the study. p-value could not be calculated between reporting groups for specified rows with 100% response. | Posted | Count of Participants | Participants | During pre-index period (12 months duration before the index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
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| Primary | Number of Participants With Top 25 Comorbid Conditions as Per Agency for Healthcare Research and Quality (AHRQ) During Post-Index Period | Top 25 comorbid conditions: 1) rheumatoid arthritis/related disease, 2)other aftercare, 3)other connective tissue disease, 4)other non-traumatic joint disorders, 5)medical examination/evaluation, 6) other suspected conditions(other miscellaneous conditions other than mental disorders/infectious disease), 7)immunizations/screening for infectious disease, 8)osteoarthritis, 9)essential hypertension, 10) residual codes: unclassified, 11)disorders of lipid metabolism, 12)back problems, 13)other upper respiratory infections, 14)other lower respiratory disease, 15)other nervous system disorders, 16)other skin disorders, 17)thyroid disorders, 18)other bone disease/musculoskeletal deformities, 19) malaise/fatigue, 20)esophageal disorders, 21)nutritional deficiencies, 22)other nutritional: endocrine, metabolic disorders, 23)diabetes mellitus without complication, 24)other/unspecified benign neoplasm, 25)Other upper respiratory disease. A participant could have had >=1 comorbidity. | Analysis was performed on all participants included in the study. | Posted | Count of Participants | Participants | During post-index period (12 months duration post index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
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| Primary | Mean Claims Based Index of RA Severity (CIRAS) Score During Pre-Index Period | The mean of the CIRAS score during pre-index period is reported. The CIRAS is based on claims at any time during the 12-month pre-index period, used to measure RA disease severity using 9 measures (age at index, gender, inflammatory marker test ordered, rehabilitation visit, rheumatoid factor test, Felty's syndrome, number of platelet counts ordered, number of chemistry panels ordered, rheumatologist visit). Value of all 9 measure was used to derive the overall CIRAS score which ranges from 0-7.9 with higher value indicating greater severity of RA. | Analysis was performed on all participants included in the study. | Posted | Mean | Standard Deviation | score on a scale | During pre-index period (12 months duration before the index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
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| Primary | Number of Participants With 25 Most Common Medications Use During Pre-Index Period | Number of participants with 25 most common medications use during the pre-index period are reported. The 25 most medications: 1) MTX sodium, 2) folic acid, 3) prednisone, 4) acetaminophen/hydrocodone bitartrate, 5) azithromycin, 6) adalimumab, 7) hydroxychloroquine sulfate, 8) etanercept, 9) levothyroxine sodium, 10) methylprednisolone, 11) omeprazole, 12) tramadol hydrochloride, 13) meloxicam, 14) amoxicillin, 15) albuterol sulfate, 16) gabapentin, 17) acetaminophen/oxycodone hydrochloride, 18) amoxicillin/clavulanate potassium, 19) cyclobenzaprine hydrochloride, 20) fluticasone propionate, 21) ciprofloxacin hydrochloride, 22) duloxetine hydrochloride, 23) atorvastatin calcium, 24) diclofenac sodium, 25) levofloxacin. A participant could have received >=1 most common medication. | Analysis was performed on all participants included in the study. | Posted | Count of Participants | Participants | During pre-index period (12 months duration before the index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
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| Primary | Number of Participants With 26 Most Common Medications Use During Post-Index Period | Number of participants with 26 most common medications use during the post-index period are reported. The 26 most common medications: 1) MTX sodium, 2) folic acid, 3) prednisone, 4) acetaminophen/hydrocodone bitartrate, 5) azithromycin, 6) adalimumab, 7) hydroxychloroquine sulfate, 8) etanercept, 9) levothyroxine sodium, 10) methylprednisolone, 11) omeprazole, 12) tramadol hydrochloride, 13) meloxicam, 14) amoxicillin, 15) albuterol sulfate, 16) gabapentin, 17) acetaminophen/oxycodone hydrochloride, 18) amoxicillin/clavulanate potassium, 19) cyclobenzaprine hydrochloride, 20) fluticasone propionate, 21) ciprofloxacin hydrochloride, 22) duloxetine hydrochloride, 23) diclofenac Sodium, 24) levofloxacin, 25) cephalexin, 26) ibuprofen. A participant could have received >=1 most common medication. | Analysis was performed on all participants included in the study. p-value could not be calculated between reporting groups for specified rows with 100% response. | Posted | Count of Participants | Participants | During post-index period (12 months duration post index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
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| Primary | Number of Participants Who Used Opioids During Pre-Index Period | Number of participants who used at least one opioid during pre-index period are reported. | Analysis was performed on all participants included in the study. | Posted | Count of Participants | Participants | During pre-index period (12 months duration before the index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
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| Primary | Number of Participants Who Used Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) During Pre-Index Period | Number of participants who used at least one NSAID during pre-index period are reported. | Analysis was performed on all participants included in the study. | Posted | Count of Participants | Participants | During pre-index period (12 months duration before the index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
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| Primary | Number of Participants Who Used Opioids During Post-Index Period | Number of participants who used at least one opioid during the post-index period are reported. | Analysis was performed on all participants included in the study. | Posted | Count of Participants | Participants | During post-index period (12 months duration post index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
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| Primary | Number of Participants Who Used NSAIDs During Post-Index Period | Number of participants who used at least one NSAID during the post-index period are reported. | Analysis was performed on all participants included in the study. | Posted | Count of Participants | Participants | During post-index period (12 months duration post index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
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| Primary | Mean Number of Pharmacy Claims for Opioids During Pre-Index Period | The mean number of pharmacy claims for opioids during the pre-index period are reported. A pharmacy claim is defined as a claim made by participants to their insurance provider in purchasing opioids from their pharmacy. | Analysis was performed on all participants included in the study. Here, "overall number of participants analyzed" signifies the participants evaluable for this outcome measure. | Posted | Mean | Standard Deviation | pharmacy claims | During pre-index period (12 months duration before the index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
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| Primary | Mean Number of Pharmacy Claims for Non-Steroidal Anti Inflammatory Drugs (NSAIDs) During Pre-Index Period | The mean number of pharmacy claims for NSAIDs during the pre-index period are reported. A pharmacy claim is defined as a claim made by participants to their insurance provider in purchasing NSAIDs from their pharmacy. | Analysis was performed on all participants included in the study. Here, "overall number of participants analyzed" signifies the participants evaluable for this outcome measure. | Posted | Mean | Standard Deviation | pharmacy claims | During pre-index period (12 months duration before the index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
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| Primary | Mean Number of Pharmacy Claims for Opioids During Post-Index Period | The mean number of pharmacy claims for opioids during the post-index period are reported. A pharmacy claim is defined as a claim made by participants to their insurance provider in purchasing opioids from their pharmacy. | Analysis was performed on all participants included in the study. Here, "overall number of participants analyzed" signifies the participants evaluable for this outcome measure. | Posted | Mean | Standard Deviation | pharmacy claims | During post-index period (12 months duration post index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
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| Primary | Mean Number of Pharmacy Claims for Non-Steroidal Anti Inflammatory Drugs (NSAIDs) During Post-Index Period | The mean number of pharmacy claims for NSAIDs during the post-index period are reported. A pharmacy claim is defined as a claim made by participants to their insurance provider in purchasing NSAIDs from their pharmacy. | Analysis was performed on all participants included in the study. Here, "overall number of participants analyzed" signifies the participants evaluable for this outcome measure. | Posted | Mean | Standard Deviation | pharmacy claims | During post-index period (12 months duration post index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
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| Primary | Mean Number of Days From The Index Date to The First Opioid Claim During Post Index Period | Mean number of days from the index date to the first opioid claim during post index period are reported. | Analysis was performed on all participants included in the study. Here, "overall number of participants analyzed" signifies the participants evaluable for this outcome measure. | Posted | Mean | Standard Deviation | days | During post-index period (12 months duration post index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
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| Primary | Mean Number of Days From The Index Date to The First NSAIDs Claim During Post Index Period | Mean number of days from the index date to the first NSAIDs claim during post index period are reported. | Analysis was performed on all participants included in the study. Here, "overall number of participants analyzed" signifies the participants evaluable for this outcome measure. | Posted | Mean | Standard Deviation | days | During post-index period (12 months duration post index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
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| Primary | Number of Participants Who Used Opioids During Tofacitinib Persistency and Post-Persistency | Number of participants who used opioids during tofacitinib persistency and post-persistency are reported. Persistence for participants is defined as the period of treatment with tofacitinib. Post persistence refers to switching to another medication from tofacitinib; or discontinuing tofacitinib either permanently or for a gap in time >60 days before restarting. | Analysis was performed on all participants included in the study. | Posted | Count of Participants | Participants | During post-index period (12 months duration post index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
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| Primary | Number of Participants Who Used NSAIDs During Tofacitinib Persistency and Post-Persistency | Number of participants who used NSAIDs during tofacitinib persistency and post-persistency are reported. Persistence for participants is defined as the period of treatment with tofacitinib. Post persistence refers to switching to another medication from tofacitinib; or discontinuing tofacitinib either permanently or for a gap in time >60 days before restarting. | Analysis was performed on all participants included in the study. | Posted | Count of Participants | Participants | During post-index period (12 months duration post index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
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| Primary | Number of Participants Who Used Oral Corticosteroids During Pre-Index Period | The number of participants who used at least one oral corticosteroid during the pre-index period is reported. | Analysis was performed on all participants included in the study. | Posted | Count of Participants | Participants | During pre-index period (12 months duration before the index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
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| Primary | Number of Participants Who Used Oral Corticosteroids During Post-Index Period | The number of participants who used at least one oral corticosteroid during the post-index period is reported. | Analysis was performed on all participants included in the study. | Posted | Count of Participants | Participants | During post-index period (12 months duration post index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
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| Primary | Mean Total Dose of Oral Corticosteroids During Pre-Index Period | Mean total dose of oral corticosteroids during pre-index period is reported. The total dose is expressed as a prednisone-equivalent dose of the oral corticosteroids used. | Analysis was performed on all participants included in the study. Here, "overall number of participants analyzed" signifies the participants evaluable for this outcome measure. | Posted | Mean | Standard Deviation | milligram(mg) | During pre-index period (12 months duration before the index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
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| Primary | Mean Total Dose of Oral Corticosteroid During Post-Index Period | Mean total dose of oral corticosteroids during post-index period is reported. The total dose is expressed as a prednisone-equivalent dose of the oral corticosteroids used. | Analysis was performed on all participants included in the study. Here, "overall number of participants analyzed" signifies the participants evaluable for this outcome measure. | Posted | Mean | Standard Deviation | mg | During post-index period (12 months duration post index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
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| Primary | Mean Number of Visits to Rheumatologist During Pre-Index Period | Mean number of visits to a rheumatologist during pre-index period is reported. A visit is referring to out-patient visit specifically to a rheumatologist. | Analysis was performed on all participants included in the study. Here, "overall number of participants analyzed" signifies the participants evaluable for this outcome measure. | Posted | Mean | Standard Deviation | visits | During pre-index period (12 months duration before the index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
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| Primary | Mean Number of Visits to Rheumatologist During Variable-Length Pre-Index Period | Mean number of visits to rheumatologist during the variable-length pre-index period is reported. A visit is referring to out-patient visit specifically to a rheumatologist. Variable-length pre-index period defined as the period from the participant's first date of enrollment in the database to the day before the index date. The date of enrollment had to be at least 1 year prior to the index date and depending on the participant could have been as much as maximum of 5.2 years. The index date was the date of the first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years. | Analysis was performed on all participants included in the study. Here, "overall number of participants analyzed" signifies the participants evaluable for this outcome measure. | Posted | Mean | Standard Deviation | visits | During variable length pre-index period (1 year before the index date up to 5.2 years) |
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| Primary | Mean Disease Duration | Mean Disease Duration of RA based upon the variable length pre-index period is reported. Disease duration (in days) defined as the number of days from the earliest claim with a diagnosis of RA in the variable length pre-index period until the index date. Variable-length pre-index period defined as the period from the participant's first date of enrollment in the database to the day before the index date. The date of enrollment had to be at least 1 year prior to the index date and depending on the participant could have been as much as maximum of 5.2 years. The index date was the date of the first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years. | Analysis was performed on all participants included in the study. | Posted | Mean | Standard Deviation | days | During variable length pre-index period (1 year before the index date up to 5.2 years) |
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| Primary | Mean Out of Pocket Health Care Costs for Healthcare Services During Pre-Index Period | Mean out of pocket health care costs for healthcare services during pre-index period is reported. It is categorized as: All causes and RA related. All cause consisted of money spent by participants on all health care services (pharmacy, medical [ambulatory, emergency department and inpatient admission]). RA related signifies money spent by participants on health care services for RA. | Analysis was performed on all participants included in the study. | Posted | Mean | Standard Deviation | dollars | During pre-index period (12 months duration before the index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
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| Primary | Mean Out of Pocket Health Care Costs for Healthcare Services During Variable Length Pre-Index Period | Mean out of pocket health care costs for healthcare services during variable length pre-index period is reported. It is categorized as: All causes and RA related. All cause consisted of money spent by participants on all health care services (pharmacy, medical [ambulatory, emergency department and inpatient admission]). RA related signifies one spent by participants on health care services for RA. Variable-length pre-index period defined as the period from the participant's first date of enrollment in the database to the day before the index date. The date of enrollment had to be at least 1 year prior to the index date and depending on the participant could have been as much as maximum of 5.2 years. The index date was the date of the first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years. | Analysis was performed on all participants included in the study. | Posted | Mean | Standard Deviation | dollars | During variable length pre-index period (1 year before the index date up to 5.2 years) |
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| Primary | Number of Participants With Comorbidities of Interest During Pre-Index Period | Number of participants with at least one of comorbidity of interest during pre-index period is reported. The comorbidities of interest included cardiovascular diseases, chronic obstructive pulmonary disorder (COPD), asthma, kidney disease, diabetes, depression, anxiety, liver disease, sleep disorders. A participant could have >1 comorbidity of interest. | Analysis was performed on all participants included in the study. | Posted | Count of Participants | Participants | During pre-index period (12 months duration before the index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
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| Primary | Number of Participants With Non-persistence to Index Medication (Tofacitinib) | Non-persistence was defined as the gap of at least 60 days in treatment with the index medication (tofacitinib) or switching to other biologic. | Analysis was performed on all participants included in the study. | Posted | Count of Participants | Participants | During post-index period (12 months duration post index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
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| Primary | Number of Participants With Post-Persistence Treatment Patterns | Number of participants with post-persistence treatment patterns is reported. Post-persistence was categorized as: 1) switch immediately (if participants initiated a non-index biologic before a 60-day gap in treatment is observed for the index medication); 2) discontinue then restart (if there was a gap in the index therapy of at least 60 days and the first medication observed after the gap is the index medication); 3) discontinue then switch ( if there was a gap in the index therapy of at least 60 days and the first medication observed after the gap is a biologic [including Tofacitinib] different from index medication), 4) discontinue without switch or restart (if participant's had a gap in therapy of at least 60 days and there are no claims for either the index medication or a different biologic for the remaining observation period). | Analysis was performed on all participants included in the study. | Posted | Count of Participants | Participants | During post-index period (12 months duration post index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
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| Primary | Number of Participants Who Switched From Index Medication (Tofacitinib) at Any Time During Post-Index Period | Number of participants who switched from index medication (tofacitinib) to a biologic at any time during post-index period is reported. | Analysis was performed on all participants included in the study. | Posted | Count of Participants | Participants | During post-index period (12 months duration post index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
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| Primary | Number of Participants Who Re-started Index Medication (Tofacitinib) at Any Time During Post-Index Period | Number of participants who re-started tofacitinib (after considered as non-persistence with the tofacitinib) after discontinuation at any time during post-index period is reported. | Analysis was performed on all participants included in the study. Here, "overall number of participants analyzed" signifies the participants evaluable for this outcome measure. | Posted | Count of Participants | Participants | During post-index period (12 months duration post index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
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| Primary | Mean Medication Possession Ratio (MPR) for Methotrexate (MTX) | Mean MPR for Methotrexate is reported. MPR was calculated as the total days supply of MTX between the first and including the last prescription/administration divided by the time between the first through and including last biologic prescription/administration days supply. | Analysis was performed on all participants included in the study. Analysis was performed on "MTX persistent" participants only and the data for this OM was not planned to be collected and analyzed for "MTX Discontinued" and "MTX Interrupted". | Posted | Mean | Standard Deviation | ratio | During post-index period (12 months duration post index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
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| Primary | Mean Adherence To Methotrexate (MTX) | Mean adherence for methotrexate is reported. Adherence was calculated as the total number of days supplied for MTX during the post-index period divided by the number of days from the first claim during the post-index period to the end of the post-index period | Analysis was performed on all participants included in the study. | Posted | Mean | Standard Deviation | ratio | During post-index period (12 months duration post index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
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| Primary | Number of Participants Who Used Additional NB-DMARD During Post Index Period | Number of participants who used additional NB-DMARD during post index period is reported. Additional NB-DMARD use could have been leflunomide, sulfasalazine and hydroxychloroquine. | Analysis was performed on all participants included in the study. | Posted | Count of Participants | Participants | During post-index period (12 months duration post index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
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| Primary | Number of Participants Who Met Medication Effectiveness Criteria: Adherence to Index Medication (Tofacitinib) | Medication effectiveness criteria categorized as: 1) adherence to index medication, 2) no dose escalation for index medication, 3) no switch from index medication, 4) no addition of NB-DMARD, 5) criteria for oral glucocorticoids, 6) use of Injectable glucocorticoids. Adherence to index medication was defined as at least 30 days continuous supply of tofacitinib during post-index period. | Analysis was performed on all participants included in the study. | Posted | Count of Participants | Participants | During post-index period (12 months duration post index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
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| Primary | Number of Participants Who Met Medication Effectiveness Criteria: No Dose Escalation for Index Medication (Tofacitinib) | Medication effectiveness criteria categorized as: 1) adherence to index medication, 2) no dose escalation for index medication, 3) no switch from index medication, 4) no addition of NB-DMARD, 5) criteria for oral glucocorticoids, 6) use of Injectable glucocorticoids. No dose escalation for index medication was defined as no increase in dose for index medication compared to the starting dose during post-index period. | Analysis was performed on all participants included in the study. | Posted | Count of Participants | Participants | During post-index period (12 months duration post index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
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| Primary | Number of Participants Who Met Medication Effectiveness Criteria: No Switch From Index Medication (Tofacitinib) | Medication effectiveness criteria categorized as: 1) adherence to index medication, 2) no dose escalation for index medication, 3) no switch from index medication, 4) no addition of NB-DMARD, 5) criteria for oral glucocorticoids, 6) use of Injectable glucocorticoids. No switch from index medication was defined as no switching from the index medication to a (different) biologic agent during post-index period. | Analysis was performed on all participants included in the study. | Posted | Count of Participants | Participants | During post-index period (12 months duration post index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
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| Primary | Number of Participants Who Met Medication Effectiveness Criteria: No Addition of NB-DMARD | Medication effectiveness criteria categorized as: 1) adherence to index medication, 2) no dose escalation for index medication, 3) no switch from index medication, 4) no addition of NB-DMARD, 5) criteria for oral glucocorticoids, 6) use of Injectable glucocorticoids. No addition of NB-DMARD was defined as no addition of new NB-DMARD to index therapy during post-index period. | Analysis was performed on all participants included in the study. | Posted | Count of Participants | Participants | During post-index period (12 months duration post index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
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| Primary | Number of Participants Who Met Medication Effectiveness Criteria: Criteria for Oral Glucocorticoids | Medication effectiveness criteria categorized as: 1) adherence to index medication, 2) no dose escalation for index medication, 3) no switch from index medication, 4) no addition of NB-DMARD, 5) criteria for oral glucocorticoids, 6) use of Injectable glucocorticoids. Medication effectiveness criteria for oral glucocorticoids was defined as either of the following: 1) Participants cannot receive oral glucocorticoids for > 30 days between (index date +91 days) to (index date + 359 days); 2) No increase in oral glucocorticoid dose during months 6-12 after index date. | Analysis was performed on all participants included in the study. | Posted | Count of Participants | Participants | During post-index period (12 months duration post index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
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| Primary | Number of Participants Who Met Medication Effectiveness Criteria: Use of Injectable Glucocorticoids | Medication effectiveness criteria categorized as: 1) adherence to index medication, 2) no dose escalation for index medication, 3) no switch from index medication, 4) no addition of NB-DMARD, 5) criteria for oral glucocorticoids, 6) use of Injectable glucocorticoids. Use of Injectable glucocorticoids was defined as maximum one parenteral or intra-articular glucocorticoid joint injection use after the participant had been on biologic treatment for >3 months post index date ([index date +91 days] to [index date +359 days]). | Analysis was performed on all participants included in the study. | Posted | Count of Participants | Participants | During post-index period (12 months duration post index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
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| Primary | Number of Participants With All Cause Ambulatory Visits During Pre-Index Period | Number of participants with at least one ambulatory visit that was due to all cause during the pre-index period is reported. All cause refers to ambulatory visits due to all comorbidities, including RA. | Analysis was performed on all participants included in the study. | Posted | Count of Participants | Participants | During pre-index period (12 months duration before the index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
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| Primary | Number of Participants With All Cause Emergency Department Visits During Pre-Index Period | Number of participants with at least one emergency department visits that was due to all cause during the pre-index period is reported. All cause refers to emergency visits due to all comorbidities, including RA. | Analysis was performed on all participants included in the study. | Posted | Count of Participants | Participants | During pre-index period (12 months duration before the index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
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| Primary | Number of Participants With All Cause Inpatient Admissions During Pre-Index Period | Number of participants with at least one inpatient admissions that was due to all cause during the pre-index period is reported. All cause refers to inpatient admission due to all comorbidities, including RA. | Analysis was performed on all participants included in the study. | Posted | Count of Participants | Participants | During pre-index period (12 months duration before the index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
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| Primary | Number of Participants With RA Related Ambulatory Visits During Pre-Index Period | Number of participants with at least one ambulatory visit that was due to RA during the pre-index period is reported. RA related refers to ambulatory visits due to RA. | Analysis was performed on all participants included in the study. p-value could not be calculated for reporting groups with 100% response. | Posted | Count of Participants | Participants | During pre-index period (12 months duration before the index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
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| Primary | Number of Participants With RA Related Emergency Department Visits During Pre-Index Period | Number of participants with at least one emergency department visits that was due to RA during the pre-index period is reported. RA related refers to emergency department visits due to RA. | Analysis was performed on all participants included in the study. | Posted | Count of Participants | Participants | During pre-index period (12 months duration before the index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
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| Primary | Number of Participants With RA Related Inpatient Admissions During Pre-Index Period | Number of participants with at least one inpatient admissions that was due to RA during the pre-index period is reported. RA related refers to inpatient admission due to RA. | Analysis was performed on all participants included in the study. | Posted | Count of Participants | Participants | During pre-index period (12 months duration before the index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
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| Primary | Number of Participants With All Cause Ambulatory Visits During Post-Index Period | Number of participants with at least one ambulatory visit that was due to all cause during the post-index period is reported. All cause refers to ambulatory visits due to all comorbidities, including RA. | Analysis was performed on all participants included in the study. | Posted | Count of Participants | Participants | During post-index period (12 months duration post index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
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| Primary | Number of Participants With All Cause Emergency Department Visits During Post-Index Period | Number of participants with at least one emergency department visits that was due to all cause during the post-index period is reported. All cause refers to emergency department visits due to all comorbidities, including RA. | Analysis was performed on all participants included in the study. | Posted | Count of Participants | Participants | During post-index period (12 months duration post index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
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| Primary | Number of Participants With All Cause Inpatient Admissions During Post-Index Period | Number of participants with at least one inpatient admissions that was due to all cause during the post-index period is reported. All cause refers to inpatient admissions due to all comorbidities, including RA. | Analysis was performed on all participants included in the study. | Posted | Count of Participants | Participants | During post-index period (12 months duration post index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
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| Primary | Number of Participants With RA Related Ambulatory Visits During Post Index Period | Number of participants with at least one of the RA-related ambulatory visits during the post-index period is reported. RA related refers to ambulatory visits due to RA. | Analysis was performed on all participants included in the study | Posted | Count of Participants | Participants | During post-index period (12 months duration post index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
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| Primary | Number of Participants With RA Related Emergency Department Visits During Post Index Period | Number of participants with at least one of the RA-related emergency department visit during the post-index period is reported. RA related refers to emergency department visits due to RA. | Analysis was performed on all participants included in the study | Posted | Count of Participants | Participants | During post-index period (12 months duration post index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
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| Primary | Number of Participants With RA Related Inpatient Admissions During Post Index Period | Number of participants with at least one of an RA-related inpatient admission during the post-index period is reported. RA related refers to inpatient admissions due to RA. | Analysis was performed on all participants included in the study | Posted | Count of Participants | Participants | During post-index period (12 months duration post index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
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| Primary | Mean Total Health Care Cost All Cause During Pre-Index Period | Mean total health care cost all cause during pre-index period is reported. All cause refers to cost spent due to all comorbidities including RA and calculated as the total of pharmacy cost (home healthcare cost, urgent care cost and other medical services costs) and medical cost (ambulatory cost, emergency department visits cost, inpatient admission cost and other costs). | Analysis was performed on all participants included in the study. | Posted | Mean | Standard Deviation | dollars | During pre-index period (12 months duration before the index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
|
|
|
|
| Primary | Mean Total Health Care Cost RA Related During Pre-Index Period | RA related healthcare cost refers to cost spent due to RA alone and was calculated as the total of treatment cost (cost of tofacitinib, biologic DMARDs, NB-DMARDs and administration of intravenous (IV) biologics) and medical cost (cost of ambulatory cost, emergency department visits cost, inpatient admission cost, home health care cost, urgent care cost and other medical services cost). | Analysis was performed on all participants included in the study. | Posted | Mean | Standard Deviation | dollars | During pre-index period (12 months duration before the index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
|
|
|
|
| Primary | Mean Total Health Care Cost Due to All Cause During Post-Index Period | Mean total health care cost due to all cause during post-index period is reported. All cause refers to cost spent due to all comorbidities, including RA and calculated as the total of pharmacy cost (cost of home healthcare cost, urgent care cost and other medical services costs) and medical cost (cost of ambulatory cost, emergency department visits cost, inpatient admission cost and other costs). | Analysis was performed on all participants included in the study. | Posted | Mean | Standard Deviation | dollars | During post-index period (12 months duration post index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
|
|
|
|
| Primary | Mean Total Health Care Cost RA Related During Post-Index Period | RA related healthcare cost refers to cost spent due to RA alone and was calculated as the total of treatment cost (cost of tofacitinib, biologic DMARDs, NB-DMARDs and administration of IV biologics) and medical cost (ambulatory cost, emergency department visits cost, inpatient admission cost, home health care cost, urgent care cost and other medical services cost). | Analysis was performed on all participants included in the study. | Posted | Mean | Standard Deviation | dollars | During post-index period (12 months duration post index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
|
|
|
|
| Primary | Mean Treatment Persistence Duration Measured for Index Medication (Tofacitinib) | Treatment persistence with tofacitinib was defined as not having a gap in therapy of at least 60 days between prescription re-fills of tofacitinib. | Analysis was performed on all participants included in the study. | Posted | Mean | Standard Deviation | days | During post-index period (12 months duration post index date [Index date: date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years]) |
|
|
|
|
| Secondary | Mean Total All Cause Monthly Health Care Cost | Mean total monthly health care cost due to all cause is reported. All cause refers to cost spent due to all comorbidities, including RA and calculated as the total of pharmacy cost (cost of home healthcare cost, urgent care cost and other medical services costs) and medical cost (cost of ambulatory cost, emergency department visits cost, inpatient admission cost and other costs). Total all cause monthly health care cost is reported for every month from 12 months duration before index date (pre-index period) to 12 months duration post index date (post index period). Index date is defined as the date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years. | Analysis was performed on all participants included in the study. | Posted | Mean | Standard Deviation | dollars | During pre-index period (at 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 and 12 months before index date) and post index period (at 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 and 12 month post index date) |
|
|
|
|
| Secondary | Mean Total RA Related Monthly Health Care Cost | Mean total monthly health care cost due to RA is reported. RA related refers to cost spent by participants due to RA on health care services. This is calculated as the total of treatment cost (cost of tofacitinib, biologic DMARDs, NB-DMARDs and administration of IV biologics) and medical cost (ambulatory cost, emergency department visits cost, inpatient admission cost, home health care cost, urgent care cost and other medical services cost). RA related monthly health care cost is reported for every month from 12 months duration before index date (pre-index period) to 12 months duration post index date (post index period). Index date is defined as the date of first claim for tofacitinib made by participants to their insurance provider during identification period of 3 years. | Analysis was performed on all participants included in the study. | Posted | Mean | Standard Deviation | dollars | During pre-index period (at1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 and 12 months before index date) and post index period (at 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 and 12 month after index date) |
|
|
|
|
| 0 |
| 0 |
| 0 |
| 0 |
| 0 |
| 0 |
| EG001 | Methotrexate (MTX) + Tofacitinib: MTX Discontinued | RA diagnosed participants who were privately insured or under Medicare Supplemental insurance (from their employer), initiated tofacitinib in combination with MTX, orally, between 01 January 2014 to 31 January 2017 (identification period) with a gap of >60 days in MTX therapy (discontinued) within 12 months post-index date, were included in the study and their information as per Truven Health MarketScan Research Database (from January 1, 2012 to January 2018) was assessed in this study. Index date defined as the date of first claim for tofacitinib by participants to their insurance provider during identification period. | 0 | 0 | 0 | 0 | 0 | 0 |
| EG002 | Methotrexate (MTX) + Tofacitinib: MTX Interrupted | RA diagnosed participants who were privately insured or under Medicare Supplemental insurance (from their employer), initiated tofacitinib in combination with MTX, orally, between 01 January 2014 to 31 January 2017 (identification period) with a gap of >60 days with 1 or more subsequent prescription re-fills in MTX therapy (interrupted) within 12 months post-index date, were included in the study and their information as per Truven Health MarketScan Research Database (from January 1, 2012 to January 2018) was assessed in this study. Index date defined as the date of first claim for tofacitinib by participants to their insurance provider during identification period. | 0 | 0 | 0 | 0 | 0 | 0 |
Pfizer has the right to review disclosures, requesting a delay of less than 60 days. Investigator will postpone single center publications until after disclosure of pooled data (all sites), less than 12 months from study completion/termination at all participating sites. Investigator may not disclose previously undisclosed confidential information other than study results.
| D003240 |
| Connective Tissue Diseases |
| D017437 | Skin and Connective Tissue Diseases |
| D001327 | Autoimmune Diseases |
| D007154 | Immune System Diseases |
| Male |
|
| South Region |
|
| West Region |
|
| Unknown Region |
|
| Superiority |
| Chi-squared | 0.8316 | Superiority |
| Superiority |
| Chi-squared | 0.8376 | Superiority |
| Superiority |
| t-test | 0.4546 | Superiority |
| Superiority |
| t-test | 0.7293 | Superiority |
| Superiority |
| Chi-squared | 0.6258 | Superiority |
| Superiority |
| Superiority |
| t-test | 0.9696 | Superiority |
| Superiority |
| t-test | 0.4309 | Superiority |
| Superiority |
| t-test | 0.5375 | Superiority |
|
| Other connective tissue disease |
|
| Other non-traumatic joint disorders |
|
| Medical examination/evaluation |
|
| Other suspected conditions |
|
| Immunizations/screening for infectious disease |
|
| Osteoarthritis |
|
| Essential hypertension |
|
| Residual codes; unclassified |
|
| Disorders of lipid metabolism |
|
| Back problems |
|
| Other upper respiratory infections |
|
| Other lower respiratory disease |
|
| Other nervous system disorders |
|
| Other skin disorders |
|
| Thyroid disorders |
|
| Other bone disease/musculoskeletal deformities |
|
| Malaise/fatigue |
|
| Esophageal disorders |
|
| Nutritional deficiencies |
|
| Other nutritional: endocrine, metabolic disorders |
|
| Diabetes mellitus without complication |
|
| Other/unspecified benign neoplasm |
|
| Genitourinary symptoms/ill-defined conditions |
|
| 0.2316 |
| Superiority |
| Other aftercare | Chi-squared | 0.7349 | Superiority |
| Other connective tissue disease | Chi-squared | 0.0774 | Superiority |
| Other connective tissue disease | Chi-squared | 0.4228 | Superiority |
| Other connective tissue disease | Chi-squared | 0.0583 | Superiority |
| Other non-traumatic joint disorders | Chi-squared | 0.9683 | Superiority |
| Other non-traumatic joint disorders | Chi-squared | 0.8877 | Superiority |
| Other non-traumatic joint disorders | Chi-squared | 0.9228 | Superiority |
| Medical examination/evaluation | Chi-squared | 0.7661 | Superiority |
| Medical examination/evaluation | Chi-squared | 0.3034 | Superiority |
| Medical examination/evaluation | Chi-squared | 0.2765 | Superiority |
| Other suspected conditions | Chi-squared | 0.8652 | Superiority |
| Other suspected conditions | Chi-squared | 0.2243 | Superiority |
| Other suspected conditions | Chi-squared | 0.3449 | Superiority |
| Immunizations/screening for infectious disease | Chi-squared | 0.3529 | Superiority |
| Immunizations/screening for infectious disease | Chi-squared | 0.1012 | Superiority |
| Immunizations/screening for infectious disease | Chi-squared | 0.4123 | Superiority |
| Osteoarthritis | Chi-squared | 0.2742 | Superiority |
| Osteoarthritis | Chi-squared | 0.1009 | Superiority |
| Osteoarthritis | Chi-squared | 0.0318 | Superiority |
| Essential hypertension | Chi-squared | 0.4808 | Superiority |
| Essential hypertension | Chi-squared | 0.0778 | Superiority |
| Essential hypertension | Chi-squared | 0.2871 | Superiority |
| Residual codes; unclassified | Chi-squared | 0.7356 | Superiority |
| Residual codes; unclassified | Chi-squared | 0.4975 | Superiority |
| Residual codes; unclassified | Chi-squared | 0.7143 | Superiority |
| Disorders of lipid metabolism | Chi-squared | 0.3559 | Superiority |
| Disorders of lipid metabolism | Chi-squared | 0.7725 | Superiority |
| Disorders of lipid metabolism | Chi-squared | 0.3875 | Superiority |
| Back problems | Chi-squared | 0.0225 | Superiority |
| Back problems | Chi-squared | 0.4427 | Superiority |
| Back problems | Chi-squared | 0.4094 | Superiority |
| Other upper respiratory infections | Chi-squared | 0.8775 | Superiority |
| Other upper respiratory infections | Chi-squared | 0.3525 | Superiority |
| Other upper respiratory infections | Chi-squared | 0.4724 | Superiority |
| Other lower respiratory disease | Chi-squared | 0.7170 | Superiority |
| Other lower respiratory disease | Chi-squared | 0.2909 | Superiority |
| Other lower respiratory disease | Chi-squared | 0.5057 | Superiority |
| Other nervous system disorders | Chi-squared | 0.2613 | Superiority |
| Other nervous system disorders | Chi-squared | 0.9901 | Superiority |
| Other nervous system disorders | Chi-squared | 0.4768 | Superiority |
| Other skin disorders | Chi-squared | 0.0219 | Superiority |
| Other skin disorders | Chi-squared | 0.5172 | Superiority |
| Other skin disorders | Chi-squared | 0.0278 | Superiority |
| Thyroid disorders | Chi-squared | 0.6103 | Superiority |
| Thyroid disorders | Chi-squared | 0.1682 | Superiority |
| Thyroid disorders | Chi-squared | 0.3654 | Superiority |
| Other bone disease/musculoskeletal deformities | Chi-squared | 0.7637 | Superiority |
| Other bone disease/musculoskeletal deformities | Chi-squared | 0.8693 | Superiority |
| Other bone disease/musculoskeletal deformities | Chi-squared | 0.7349 | Superiority |
| Malaise/fatigue | Chi-squared | 0.7324 | Superiority |
| Malaise/fatigue | Chi-squared | 0.4182 | Superiority |
| Malaise/fatigue | Chi-squared | 0.6200 | Superiority |
| Esophageal disorders | Chi-squared | 0.6064 | Superiority |
| Esophageal disorders | Chi-squared | 0.6360 | Superiority |
| Esophageal disorders | Chi-squared | 0.9445 | Superiority |
| Nutritional deficiencies | Chi-squared | 0.8135 | Superiority |
| Nutritional deficiencies | Chi-squared | 0.6705 | Superiority |
| Nutritional deficiencies | Chi-squared | 0.8331 | Superiority |
| Other nutritional; endocrine; and metabolic disorders | Chi-squared | 0.4158 | Superiority |
| Other nutritional; endocrine; and metabolic disorders | Chi-squared | 0.6360 | Superiority |
| Other nutritional; endocrine; and metabolic disorders | Chi-squared | 0.3336 | Superiority |
| Diabetes mellitus without complication | Chi-squared | 0.6402 | Superiority |
| Diabetes mellitus without complication | Chi-squared | 0.8068 | Superiority |
| Diabetes mellitus without complication | Chi-squared | 0.5983 | Superiority |
| Other/unspecified benign neoplasm | Chi-squared | 0.9759 | Superiority |
| Other/unspecified benign neoplasm | Chi-squared | 0.1360 | Superiority |
| Other/unspecified benign neoplasm | Chi-squared | 0.1815 | Superiority |
| Genitourinary symptoms/ill-defined conditions | Chi-squared | 0.2731 | Superiority |
| Genitourinary symptoms/ill-defined conditions | Chi-squared | 0.8327 | Superiority |
| Genitourinary symptoms/ill-defined conditions | Chi-squared | 0.3420 | Superiority |
|
| Other connective tissue disease |
|
| Other suspected conditions |
|
| Medical examination/evaluation |
|
| Other non-traumatic joint disorders |
|
| Essential hypertension |
|
| Residual codes; unclassified |
|
| Disorders of lipid metabolism |
|
| Osteoarthritis |
|
| Immunizations/screening for infectious disease |
|
| Back problems |
|
| Other upper respiratory infections |
|
| Other nervous system disorders |
|
| Other lower respiratory disease |
|
| Other skin disorders |
|
| Other nutritional, endocrine, metabolic disorders |
|
| Thyroid disorders |
|
| Other bone disease/musculoskeletal deformities |
|
| Nutritional deficiencies |
|
| Diabetes mellitus without complication |
|
| Esophageal disorders |
|
| Malaise/fatigue |
|
| Other/unspecified benign neoplasm |
|
| Other upper respiratory disease |
|
| 0.7055 |
| Superiority |
| Rheumatoid arthritis/related disease | Chi-squared | 0.3088 | Superiority |
| Other aftercare | Chi-squared | 0.0036 | Superiority |
| Other aftercare | Chi-squared | 0.3772 | Superiority |
| Other aftercare | Chi-squared | 0.3000 | Superiority |
| Other connective tissue disease | Chi-squared | 0.7354 | Superiority |
| Other connective tissue disease | Chi-squared | 0.1435 | Superiority |
| Other connective tissue disease | Chi-squared | 0.2876 | Superiority |
| Other non-traumatic joint disorders | Chi-squared | 0.2848 | Superiority |
| Other non-traumatic joint disorders | Chi-squared | 0.1830 | Superiority |
| Other non-traumatic joint disorders | Chi-squared | 0.6453 | Superiority |
| Medical examination/evaluation | Chi-squared | 0.8717 | Superiority |
| Medical examination/evaluation | Chi-squared | 0.8717 | Superiority |
| Medical examination/evaluation | Chi-squared | 0.3422 | Superiority |
| Other suspected conditions | Chi-squared | 0.3465 | Superiority |
| Other suspected conditions | Chi-squared | 0.4953 | Superiority |
| Other suspected conditions | Chi-squared | 0.9796 | Superiority |
| Immunizations/screening for infectious disease | Chi-squared | 0.4187 | Superiority |
| Immunizations/screening for infectious disease | Chi-squared | 0.1510 | Superiority |
| Immunizations/screening for infectious disease | Chi-squared | 0.0751 | Superiority |
| Osteoarthritis | Chi-squared | 0.7577 | Superiority |
| Osteoarthritis | Chi-squared | 0.8020 | Superiority |
| Osteoarthritis | Chi-squared | 0.9879 | Superiority |
| Essential hypertension | Chi-squared | 0.1717 | Superiority |
| Essential hypertension | Chi-squared | 0.3065 | Superiority |
| Essential hypertension | Chi-squared | 0.9920 | Superiority |
| Residual codes; unclassified | Chi-squared | 0.4626 | Superiority |
| Residual codes; unclassified | Chi-squared | 0.8922 | Superiority |
| Residual codes; unclassified | Chi-squared | 0.7143 | Superiority |
| Disorders of lipid metabolism | Chi-squared | 0.8212 | Superiority |
| Disorders of lipid metabolism | Chi-squared | 0.5732 | Superiority |
| Disorders of lipid metabolism | Chi-squared | 0.7319 | Superiority |
| Back problems | Chi-squared | 0.9272 | Superiority |
| Back problems | Chi-squared | 0.1441 | Superiority |
| Back problems | Chi-squared | 0.1859 | Superiority |
| Other upper respiratory infections | Chi-squared | 0.3109 | Superiority |
| Other upper respiratory infections | Chi-squared | 0.3313 | Superiority |
| Other upper respiratory infections | Chi-squared | 0.1279 | Superiority |
| Other lower respiratory disease | Chi-squared | 0.7575 | Superiority |
| Other lower respiratory disease | Chi-squared | 0.1583 | Superiority |
| Other lower respiratory disease | Chi-squared | 0.1569 | Superiority |
| Other nervous system disorders | Chi-squared | 0.0745 | Superiority |
| Other nervous system disorders | Chi-squared | 0.0933 | Superiority |
| Other nervous system disorders | Chi-squared | 0.7910 | Superiority |
| Other skin disorders | Chi-squared | 0.6755 | Superiority |
| Other skin disorders | Chi-squared | 0.4183 | Superiority |
| Other skin disorders | Chi-squared | 0.6749 | Superiority |
| Thyroid disorders | Chi-squared | 0.6626 | Superiority |
| Thyroid disorders | Chi-squared | 0.5766 | Superiority |
| Thyroid disorders | Chi-squared | 0.8376 | Superiority |
| Other bone disease/musculoskeletal deformities | Chi-squared | 0.2857 | Superiority |
| Other bone disease/musculoskeletal deformities | Chi-squared | 0.9560 | Superiority |
| Other bone disease/musculoskeletal deformities | Chi-squared | 0.4384 | Superiority |
| Malaise/fatigue | Chi-squared | 0.6082 | Superiority |
| Malaise/fatigue | Chi-squared | 0.3374 | Superiority |
| Malaise/fatigue | Chi-squared | 0.5984 | Superiority |
| Esophageal disorders | Chi-squared | 0.8568 | Superiority |
| Esophageal disorders | Chi-squared | 0.7698 | Superiority |
| Esophageal disorders | Chi-squared | 0.7089 | Superiority |
| Nutritional deficiencies | Chi-squared | 0.3446 | Superiority |
| Nutritional deficiencies | Chi-squared | 0.0815 | Superiority |
| Nutritional deficiencies | Chi-squared | 0.4020 | Superiority |
| Other nutritional: endocrine/metabolic disorders | Chi-squared | 0.4246 | Superiority |
| Other nutritional: endocrine/metabolic disorders | Chi-squared | 0.8118 | Superiority |
| Other nutritional: endocrine/metabolic disorders | Chi-squared | 0.7454 | Superiority |
| Diabetes mellitus without complication | Chi-squared | 0.3559 | Superiority |
| Diabetes mellitus without complication | Chi-squared | 0.7698 | Superiority |
| Diabetes mellitus without complication | Chi-squared | 0.7323 | Superiority |
| Other/unspecified benign neoplasm | Chi-squared | 0.5935 | Superiority |
| Other/unspecified benign neoplasm | Chi-squared | 0.3928 | Superiority |
| Other/unspecified benign neoplasm | Chi-squared | 0.7089 | Superiority |
| Other upper respiratory disease | Chi-squared | 0.8746 | Superiority |
| Other upper respiratory disease | Chi-squared | 0.3835 | Superiority |
| Other upper respiratory disease | Chi-squared | 0.4992 | Superiority |
| Superiority |
| t-test | 0.0691 | Superiority |
| Title | Measurements |
|---|---|
|
| Prednisone |
|
| Acetaminophen/Hydrocodone Bitartrate |
|
| Azithromycin |
|
| Adalimumab |
|
| Hydroxychloroquine Sulfate |
|
| Etanercept |
|
| Levothyroxine Sodium |
|
| Methylprednisolone |
|
| Omeprazole |
|
| Tramadol Hydrochloride |
|
| Meloxicam |
|
| Amoxicillin |
|
| Albuterol Sulfate |
|
| Gabapentin |
|
| Acetaminophen/Oxycodone Hydrochloride |
|
| Amoxicillin/Clavulanate Potassium |
|
| Cyclobenzaprine Hydrochloride |
|
| Fluticasone Propionate |
|
| Ciprofloxacin Hydrochloride |
|
| Duloxetine Hydrochloride |
|
| Atorvastatin Calcium |
|
| Diclofenac Sodium |
|
| Levofloxacin |
|
| 0.9978 |
| Superiority |
| MTX Sodium | Chi-squared | 0.9861 | Superiority |
| Folic Acid | Chi-squared | 0.5744 | Superiority |
| Folic Acid | Chi-squared | 0.8542 | Superiority |
| Folic Acid | Chi-squared | 0.8363 | Superiority |
| Prednisone | Chi-squared | 0.0473 | Superiority |
| Prednisone | Chi-squared | 0.0327 | Superiority |
| Prednisone | Chi-squared | 0.5348 | Superiority |
| Acetaminophen/Hydrocodone Bitartrate | Chi-squared | 0.6934 | Superiority |
| Acetaminophen/Hydrocodone Bitartrate | Chi-squared | 0.6017 | Superiority |
| Acetaminophen/Hydrocodone Bitartrate | Chi-squared | 0.4768 | Superiority |
| Azithromycin | Chi-squared | 0.2315 | Superiority |
| Azithromycin | Chi-squared | 0.2588 | Superiority |
| Azithromycin | Chi-squared | 0.8576 | Superiority |
| Adalimumab | Chi-squared | 0.5909 | Superiority |
| Adalimumab | Chi-squared | 0.0570 | Superiority |
| Adalimumab | Chi-squared | 0.0408 | Superiority |
| Hydroxychloroquine Sulfate | Chi-squared | 0.6465 | Superiority |
| Hydroxychloroquine Sulfate | Chi-squared | 0.5654 | Superiority |
| Hydroxychloroquine Sulfate | Chi-squared | 0.8371 | Superiority |
| Etanercept | Chi-squared | 0.9654 | Superiority |
| Etanercept | Chi-squared | 0.1013 | Superiority |
| Etanercept | Chi-squared | 0.1580 | Superiority |
| Levothyroxine Sodium | Chi-squared | 0.1663 | Superiority |
| Levothyroxine Sodium | Chi-squared | 0.6563 | Superiority |
| Levothyroxine Sodium | Chi-squared | 0.5785 | Superiority |
| Methylprednisolone | Chi-squared | 0.4166 | Superiority |
| Methylprednisolone | Chi-squared | 0.0636 | Superiority |
| Methylprednisolone | Chi-squared | 0.3137 | Superiority |
| Omeprazole | Chi-squared | 0.4568 | Superiority |
| Omeprazole | Chi-squared | 0.5785 | Superiority |
| Omeprazole | Chi-squared | 0.9541 | Superiority |
| Tramadol Hydrochloride | Chi-squared | 0.1956 | Superiority |
| Tramadol Hydrochloride | Chi-squared | 0.3633 | Superiority |
| Tramadol Hydrochloride | Chi-squared | 0.9481 | Superiority |
| Meloxicam | Chi-squared | 0.3653 | Superiority |
| Meloxicam | Chi-squared | 0.9255 | Superiority |
| Meloxicam | Chi-squared | 0.5137 | Superiority |
| Amoxicillin | Chi-squared | 0.6338 | Superiority |
| Amoxicillin | Chi-squared | 0.6329 | Superiority |
| Amoxicillin | Chi-squared | 0.9228 | Superiority |
| Albuterol Sulfate | Chi-squared | 0.8433 | Superiority |
| Albuterol Sulfate | Chi-squared | 0.1175 | Superiority |
| Albuterol Sulfate | Chi-squared | 0.1215 | Superiority |
| Gabapentin | Chi-squared | 0.9007 | Superiority |
| Gabapentin | Chi-squared | 0.8789 | Superiority |
| Gabapentin | Chi-squared | 0.8305 | Superiority |
| Acetaminophen/Oxycodone Hydrochloride | Chi-squared | 0.0694 | Superiority |
| Acetaminophen/Oxycodone Hydrochloride | Chi-squared | 0.8606 | Superiority |
| Acetaminophen/Oxycodone Hydrochloride | Chi-squared | 0.3363 | Superiority |
| Amoxicillin/Clavulanate Potassium | Chi-squared | 0.3319 | Superiority |
| Amoxicillin/Clavulanate Potassium | Chi-squared | 0.5615 | Superiority |
| Amoxicillin/Clavulanate Potassium | Chi-squared | 0.8898 | Superiority |
| Cyclobenzaprine Hydrochloride | Chi-squared | 0.3670 | Superiority |
| Cyclobenzaprine Hydrochloride | Chi-squared | 0.8155 | Superiority |
| Cyclobenzaprine Hydrochloride | Chi-squared | 0.7091 | Superiority |
| Fluticasone Propionate | Chi-squared | 0.9769 | Superiority |
| Fluticasone Propionate | Chi-squared | 0.5032 | Superiority |
| Fluticasone Propionate | Chi-squared | 0.5631 | Superiority |
| Ciprofloxacin Hydrochloride | Chi-squared | 0.4426 | Superiority |
| Ciprofloxacin Hydrochloride | Chi-squared | 0.5734 | Superiority |
| Ciprofloxacin Hydrochloride | Chi-squared | 0.3071 | Superiority |
| Duloxetine Hydrochloride | Chi-squared | 0.1608 | Superiority |
| Duloxetine Hydrochloride | Chi-squared | 0.4092 | Superiority |
| Duloxetine Hydrochloride | Chi-squared | 0.1215 | Superiority |
| Atorvastatin Calcium | Chi-squared | 0.7279 | Superiority |
| Atorvastatin Calcium | Chi-squared | 0.7703 | Superiority |
| Atorvastatin Calcium | Chi-squared | 0.6254 | Superiority |
| Diclofenac Sodium | Chi-squared | 0.1615 | Superiority |
| Diclofenac Sodium | Chi-squared | 0.5050 | Superiority |
| Diclofenac Sodium | Chi-squared | 0.1592 | Superiority |
| Levofloxacin | Chi-squared | 0.6088 | Superiority |
| Levofloxacin | Chi-squared | 0.4713 | Superiority |
| Levofloxacin | Chi-squared | 0.3399 | Superiority |
| Title | Measurements |
|---|---|
|
| Prednisone |
|
| Acetaminophen/Hydrocodone Bitartrate |
|
| Azithromycin |
|
| Adalimumab |
|
| Hydroxychloroquine Sulfate |
|
| Etanercept |
|
| Levothyroxine Sodium |
|
| Methylprednisolone |
|
| Omeprazole |
|
| Tramadol Hydrochloride |
|
| Meloxicam |
|
| Amoxicillin |
|
| Albuterol Sulfate |
|
| Gabapentin |
|
| Acetaminophen/Oxycodone Hydrochloride |
|
| Amoxicillin/Clavulanate Potassium |
|
| Cyclobenzaprine Hydrochloride |
|
| Fluticasone Propionate |
|
| Ciprofloxacin Hydrochloride |
|
| Duloxetine Hydrochloride |
|
| Diclofenac Sodium |
|
| Levofloxacin |
|
| Cephalexin |
|
| Ibuprofen |
|
| 0.3956 |
| Superiority |
| Folic Acid | Chi-squared | 0.5500 | Superiority |
| Folic Acid | Chi-squared | 0.7131 | Superiority |
| Folic Acid | Chi-squared | 0.9420 | Superiority |
| Prednisone | Chi-squared | 0.0571 | Superiority |
| Prednisone | Chi-squared | 0.0490 | Superiority |
| Prednisone | Chi-squared | 0.5631 | Superiority |
| Acetaminophen/Hydrocodone Bitartrate | Chi-squared | 0.2198 | Superiority |
| Acetaminophen/Hydrocodone Bitartrate | Chi-squared | 0.3850 | Superiority |
| Acetaminophen/Hydrocodone Bitartrate | Chi-squared | 0.1165 | Superiority |
| Azithromycin | Chi-squared | 0.4291 | Superiority |
| Azithromycin | Chi-squared | 0.3850 | Superiority |
| Azithromycin | Chi-squared | 0.8143 | Superiority |
| Adalimumab | Chi-squared | 0.7272 | Superiority |
| Adalimumab | Chi-squared | 0.0501 | Superiority |
| Adalimumab | Chi-squared | 0.0500 | Superiority |
| Hydroxychloroquine Sulfate | Chi-squared | 0.3116 | Superiority |
| Hydroxychloroquine Sulfate | Chi-squared | 0.4882 | Superiority |
| Hydroxychloroquine Sulfate | Chi-squared | 0.9505 | Superiority |
| Etanercept | Chi-squared | 0.4080 | Superiority |
| Etanercept | Chi-squared | 0.7644 | Superiority |
| Etanercept | Chi-squared | 0.4146 | Superiority |
| Levothyroxine Sodium | Chi-squared | 0.1348 | Superiority |
| Levothyroxine Sodium | Chi-squared | 0.5948 | Superiority |
| Levothyroxine Sodium | Chi-squared | 0.5785 | Superiority |
| Methylprednisolone | Chi-squared | 0.1033 | Superiority |
| Methylprednisolone | Chi-squared | 0.2117 | Superiority |
| Methylprednisolone | Chi-squared | 0.9920 | Superiority |
| Omeprazole | Chi-squared | 0.9212 | Superiority |
| Omeprazole | Chi-squared | 0.9212 | Superiority |
| Omeprazole | Chi-squared | 0.4384 | Superiority |
| Tramadol Hydrochloride | Chi-squared | 0.0162 | Superiority |
| Tramadol Hydrochloride | Chi-squared | 0.3239 | Superiority |
| Tramadol Hydrochloride | Chi-squared | 0.4837 | Superiority |
| Meloxicam | Chi-squared | 0.7183 | Superiority |
| Meloxicam | Chi-squared | 0.2667 | Superiority |
| Meloxicam | Chi-squared | 0.4510 | Superiority |
| Amoxicillin | Chi-squared | 0.7993 | Superiority |
| Amoxicillin | Chi-squared | 0.9896 | Superiority |
| Amoxicillin | Chi-squared | 0.8576 | Superiority |
| Albuterol Sulfate | Chi-squared | 0.9373 | Superiority |
| Albuterol Sulfate | Chi-squared | 0.1253 | Superiority |
| Albuterol Sulfate | Chi-squared | 0.1851 | Superiority |
| Gabapentin | Chi-squared | 0.8697 | Superiority |
| Gabapentin | Chi-squared | 0.9719 | Superiority |
| Gabapentin | Chi-squared | 0.9380 | Superiority |
| Acetaminophen/Oxycodone Hydrochloride | Chi-squared | 0.1079 | Superiority |
| Acetaminophen/Oxycodone Hydrochloride | Chi-squared | 0.2588 | Superiority |
| Acetaminophen/Oxycodone Hydrochloride | Chi-squared | 0.9358 | Superiority |
| Amoxicillin/Clavulanate Potassium | Chi-squared | 0.1984 | Superiority |
| Amoxicillin/Clavulanate Potassium | Chi-squared | 0.8542 | Superiority |
| Amoxicillin/Clavulanate Potassium | Chi-squared | 0.2973 | Superiority |
| Cyclobenzaprine Hydrochloride | Chi-squared | 0.1046 | Superiority |
| Cyclobenzaprine Hydrochloride | Chi-squared | 0.7961 | Superiority |
| Cyclobenzaprine Hydrochloride | Chi-squared | 0.2140 | Superiority |
| Fluticasone Propionate | Chi-squared | 0.8578 | Superiority |
| Fluticasone Propionate | Chi-squared | 0.7131 | Superiority |
| Fluticasone Propionate | Chi-squared | 0.8421 | Superiority |
| Ciprofloxacin Hydrochloride | Chi-squared | 0.7637 | Superiority |
| Ciprofloxacin Hydrochloride | Chi-squared | 0.6355 | Superiority |
| Ciprofloxacin Hydrochloride | Chi-squared | 0.5425 | Superiority |
| Duloxetine Hydrochloride | Chi-squared | 0.0410 | Superiority |
| Duloxetine Hydrochloride | Chi-squared | 0.8251 | Superiority |
| Duloxetine Hydrochloride | Chi-squared | 0.2871 | Superiority |
| Diclofenac Sodium | Chi-squared | 0.1174 | Superiority |
| Diclofenac Sodium | Chi-squared | 0.9702 | Superiority |
| Diclofenac Sodium | Chi-squared | 0.3109 | Superiority |
| Levofloxacin | Chi-squared | 0.6744 | Superiority |
| Levofloxacin | Chi-squared | 0.8121 | Superiority |
| Levofloxacin | Chi-squared | 0.9451 | Superiority |
| Cephalexin | Chi-squared | 0.1660 | Superiority |
| Cephalexin | Chi-squared | 0.9549 | Superiority |
| Cephalexin | Chi-squared | 0.3104 | Superiority |
| Ibuprofen | Chi-squared | 0.0489 | Superiority |
| Ibuprofen | Chi-squared | 0.1515 | Superiority |
| Ibuprofen | Chi-squared | 0.9481 | Superiority |
| Superiority |
| Chi-squared | 0.7964 | Superiority |
| Superiority |
| Chi-squared | 0.7293 | Superiority |
| Superiority |
| Chi-squared | 0.3467 | Superiority |
| Superiority |
| Chi-squared | 0.4702 | Superiority |
| Superiority |
| t-test | 0.4201 | Superiority |
| Superiority |
| t-test | 0.3833 | Superiority |
| Superiority |
| t-test | 0.6962 | Superiority |
| Superiority |
| t-test | 0.0358 | Superiority |
| Superiority |
| t-test | 0.4809 | Superiority |
| Superiority |
| t-test | 0.7827 | Superiority |
| Title | Measurements |
|---|---|
|
| 0.5247 |
| Superiority |
| During Persistency | Chi-squared | 0.2809 | Superiority |
| Post Persistency | Chi-squared | 0.1153 | Superiority |
| Post Persistency | Chi-squared | 0.1344 | Superiority |
| Post Persistency | Chi-squared | 0.8229 | Superiority |
| Title | Measurements |
|---|---|
|
| 0.7124 |
| Superiority |
| During Persistency | Chi-squared | 0.6148 | Superiority |
| Post Persistency | Chi-squared | 0.4876 | Superiority |
| Post Persistency | Chi-squared | 0.7826 | Superiority |
| Post Persistency | Chi-squared | 0.8337 | Superiority |
| Superiority |
| Chi-squared | 0.1406 | Superiority |
| Superiority |
| Chi-squared | 0.3388 | Superiority |
| Superiority |
| t-test | 0.1083 | Superiority |
| Superiority |
| t-test | 0.6496 | Superiority |
| Superiority |
| t-test | 0.5577 | Superiority |
| Superiority |
| t-test | 0.2764 | Superiority |
| Superiority |
| t-test | 0.3295 | Superiority |
|
| Superiority |
| All cause | t-test | 0.0041 | Superiority |
| RA related | t-test | 0.2277 | Superiority |
| RA related | t-test | 0.2812 | Superiority |
| RA related | t-test | 0.0772 | Superiority |
|
| Superiority |
| All cause | t-test | 0.1530 | Superiority |
| RA related | t-test | 0.9439 | Superiority |
| RA related | t-test | 0.4477 | Superiority |
| RA related | t-test | 0.4519 | Superiority |
| Title | Measurements |
|---|---|
|
| Asthma |
|
| Kidney disease |
|
| Diabetes |
|
| Depression |
|
| Anxiety |
|
| Liver disease |
|
| Sleep disorders |
|
| 0.8021 |
| Superiority |
| Cardiovascular Disease | Chi-squared | 0.8376 | Superiority |
| COPD | Chi-squared | 0.5927 | Superiority |
| COPD | Chi-squared | 0.5202 | Superiority |
| COPD | Chi-squared | 0.8517 | Superiority |
| Asthma | Chi-squared | 8.33 | Superiority |
| Asthma | Chi-squared | 0.7483 | Superiority |
| Asthma | Chi-squared | 0.9713 | Superiority |
| Kidney disease | Chi-squared | 0.9148 | Superiority |
| Kidney disease | Chi-squared | 0.7248 | Superiority |
| Kidney disease | Chi-squared | 0.8200 | Superiority |
| Diabetes | Chi-squared | 0.9657 | Superiority |
| Diabetes | Chi-squared | 0.9255 | Superiority |
| Diabetes | Chi-squared | 0.9575 | Superiority |
| Depression | Chi-squared | 0.9410 | Superiority |
| Depression | Chi-squared | 0.9146 | Superiority |
| Depression | Chi-squared | 0.9641 | Superiority |
| Anxiety | Chi-squared | 0.2596 | Superiority |
| Anxiety | Chi-squared | 0.2228 | Superiority |
| Anxiety | Chi-squared | 0.7824 | Superiority |
| Liver disease | Chi-squared | 0.4184 | Superiority |
| Liver disease | Chi-squared | 0.4371 | Superiority |
| Liver disease | Chi-squared | 0.2074 | Superiority |
| Sleep disorders | Chi-squared | 0.7850 | Superiority |
| Sleep disorders | Chi-squared | 0.1288 | Superiority |
| Sleep disorders | Chi-squared | 0.2839 | Superiority |
| Superiority |
| Chi-squared | 0.0557 | Superiority |
|
| Discontinue then restart |
|
| Discontinue without switch or restart |
|
| 0.9255 |
| Superiority |
| Switch immediately | Chi-squared | 0.7824 | Superiority |
| Discontinue then switch | Chi-squared | 0.3975 | Superiority |
| Discontinue then switch | Chi-squared | 0.0552 | Superiority |
| Discontinue then switch | Chi-squared | 0.3914 | Superiority |
| Discontinue then restart | Chi-squared | 0.2036 | Superiority |
| Discontinue then restart | Chi-squared | 0.1336 | Superiority |
| Discontinue then restart | Chi-squared | 0.7095 | Superiority |
| Discontinue without switch or restart | Chi-squared | 0.2241 | Superiority |
| Discontinue without switch or restart | Chi-squared | 0.0024 | Superiority |
| Discontinue without switch or restart | Chi-squared | 0.1204 | Superiority |
| Superiority |
| Chi-squared | 0.3336 | Superiority |
| Superiority |
| Chi-squared | 0.7095 | Superiority |
| Superiority |
| t-test | <.0001 | Superiority |
| Title | Measurements |
|---|---|
|
| Hydroxychloroquine |
|
| 0.9978 |
| Superiority |
| Leflunomide | Chi-squared | 0.2629 | Superiority |
| Sulfasalazine | Chi-squared | 0.0225 | Superiority |
| Sulfasalazine | Chi-squared | 0.4456 | Superiority |
| Sulfasalazine | Chi-squared | 0.5065 | Superiority |
| Hydroxychloroquine | Chi-squared | 0.6617 | Superiority |
| Hydroxychloroquine | Chi-squared | 0.7309 | Superiority |
| Hydroxychloroquine | Chi-squared | 0.9861 | Superiority |
| Superiority |
| Chi-squared | 0.0065 | Superiority |
| Superiority |
| Chi-squared | 0.2109 | Superiority |
| Superiority |
| Chi-squared | 0.3336 | Superiority |
| Superiority |
| Chi-squared | 0.1897 | Superiority |
| Superiority |
| Chi-squared | 0.4434 | Superiority |
| Superiority |
| Chi-squared | 0.3336 | Superiority |
| Superiority |
| Chi-squared | 0.9612 | Superiority |
| Superiority |
| Chi-squared | 0.7635 | Superiority |
| Superiority |
| Superiority |
| Chi-squared | 0.9676 | Superiority |
| Superiority |
| Chi-squared | 0.3950 | Superiority |
| Superiority |
| Chi-squared | 0.1810 | Superiority |
| Superiority |
| Chi-squared | 0.0439 | Superiority |
| Superiority |
| Chi-squared | 0.3088 | Superiority |
| Superiority |
| Chi-squared | 0.8517 | Superiority |
| Superiority |
| Chi-squared | 0.0046 | Superiority |
| Superiority |
| t-test | 0.7043 | Superiority |
| Superiority |
| t-test | 0.3740 | Superiority |
| Superiority |
| t-test | 0.8349 | Superiority |
| Superiority |
| t-test | 0.2964 | Superiority |
| Superiority |
| t-test | 0.0535 | Superiority |
|
| 3 months before index date |
|
| 4 months before index date |
|
| 5 months before index date |
|
| 6 months before index date |
|
| 7 months before index date |
|
| 8 months before index date |
|
| 9 months before index date |
|
| 10 months before index date |
|
| 11 months before index date |
|
| 12 months before index date |
|
| 1 month after index date |
|
| 2 months after index date |
|
| 3 months after index date |
|
| 4 months after index date |
|
| 5 months after index date |
|
| 6 months after index date |
|
| 7 months after index date |
|
| 8 months after index date |
|
| 9 months after index date |
|
| 10 months after index date |
|
| 11 months after index date |
|
| 12 months after index date |
|
| 0.3041 |
| Superiority |
| 1 months before index date | t-test | 0.4432 | Superiority |
| 2 months before index date | t-test | 0.8641 | Superiority |
| 2 months before index date | t-test | 0.0435 | Superiority |
| 2 months before index date | t-test | 0.1530 | Superiority |
| 3 months before index date | t-test | 0.1188 | Superiority |
| 3 months before index date | t-test | 0.6807 | Superiority |
| 3 months before index date | t-test | 0.1772 | Superiority |
| 4 months before index date | t-test | 0.6104 | Superiority |
| 4 months before index date | t-test | 0.9564 | Superiority |
| 4 months before index date | t-test | 0.7688 | Superiority |
| 5 months before index date | t-test | 0.5685 | Superiority |
| 5 months before index date | t-test | 0.5122 | Superiority |
| 5 months before index date | t-test | 0.4321 | Superiority |
| 6 months before index date | t-test | 0.7892 | Superiority |
| 6 months before index date | t-test | 0.2874 | Superiority |
| 6 months before index date | t-test | 0.2662 | Superiority |
| 7 months before index date | t-test | 0.3091 | Superiority |
| 7 months before index date | t-test | 0.5783 | Superiority |
| 7 months before index date | t-test | 0.4021 | Superiority |
| 8 months before index date | t-test | 0.7670 | Superiority |
| 8 months before index date | t-test | 0.6978 | Superiority |
| 8 months before index date | t-test | 0.6328 | Superiority |
| 9 months before index date | t-test | 0.0541 | Superiority |
| 9 months before index date | t-test | 0.6999 | Superiority |
| 9 months before index date | t-test | 0.3590 | Superiority |
| 10 months before index date | t-test | 0.9360 | Superiority |
| 10 months before index date | t-test | 0.6260 | Superiority |
| 10 months before index date | t-test | 0.7797 | Superiority |
| 11 months before index date | t-test | 0.0934 | Superiority |
| 11 months before index date | t-test | 0.3960 | Superiority |
| 11 months before index date | t-test | 0.4292 | Superiority |
| 12 months before index date | t-test | 0.8540 | Superiority |
| 12 months before index date | t-test | 0.9600 | Superiority |
| 12 months before index date | t-test | 0.9374 | Superiority |
| 1 month after index date | t-test | 0.6674 | Superiority |
| 1 month after index date | t-test | 0.0776 | Superiority |
| 1 month after index date | t-test | 0.3350 | Superiority |
| 2 month after index date | t-test | 0.8461 | Superiority |
| 2 month after index date | t-test | 0.8111 | Superiority |
| 2 month after index date | t-test | 0.7267 | Superiority |
| 3 month after index date | t-test | 0.2453 | Superiority |
| 3 month after index date | t-test | 0.5889 | Superiority |
| 3 month after index date | t-test | 0.4162 | Superiority |
| 4 month after index date | t-test | 0.0307 | Superiority |
| 4 month after index date | t-test | 0.1147 | Superiority |
| 4 month after index date | t-test | 0.9481 | Superiority |
| 5 month after index date | t-test | 0.4455 | Superiority |
| 5 month after index date | t-test | 0.9445 | Superiority |
| 5 month after index date | t-test | 0.6191 | Superiority |
| 6 month after index date | t-test | 0.0805 | Superiority |
| 6 month after index date | t-test | 0.7037 | Superiority |
| 6 month after index date | t-test | 0.4288 | Superiority |
| 7 month after index date | t-test | 0.3731 | Superiority |
| 7 month after index date | t-test | 0.4803 | Superiority |
| 7 month after index date | t-test | 0.5831 | Superiority |
| 8 month after index date | t-test | 0.0944 | Superiority |
| 8 month after index date | t-test | 0.8800 | Superiority |
| 8 month after index date | t-test | 0.4949 | Superiority |
| 9 month after index date | t-test | 0.6373 | Superiority |
| 9 month after index date | t-test | 0.0497 | Superiority |
| 9 month after index date | t-test | 0.1695 | Superiority |
| 10 month after index date | t-test | 0.6373 | Superiority |
| 10 month after index date | t-test | 0.7866 | Superiority |
| 10 months after index date | t-test | 0.7643 | Superiority |
| 11 month after index date | t-test | 0.2307 | Superiority |
| 11 month after index date | t-test | 0.6712 | Superiority |
| 11 months after index date | t-test | 0.6953 | Superiority |
| 12 month after index date | t-test | 0.3675 | Superiority |
| 12 month after index date | t-test | 0.8027 | Superiority |
| 12 month after index date | t-test | 0.4817 | Superiority |
|
| 3 months before index date |
|
| 4 months before index date |
|
| 5 months before index date |
|
| 6 months before index date |
|
| 7 months before index date |
|
| 8 months before index date |
|
| 9 months before index date |
|
| 10 months before index date |
|
| 11 months before index date |
|
| 12 months before index date |
|
| 1 month after index date |
|
| 2 months after index date |
|
| 3 months after index date |
|
| 4 months after index date |
|
| 5 months after index date |
|
| 6 months after index date |
|
| 7 months after index date |
|
| 8 months after index date |
|
| 9 months after index date |
|
| 10 months after index date |
|
| 11 months after index date |
|
| 12 months after index date |
|
| 0.0162 |
| Superiority |
| 1 month before index date | t-test | 0.8715 | Superiority |
| 2 months before index date | t-test | 0.2799 | Superiority |
| 2 months before index date | t-test | 0.0126 | Superiority |
| 2 months before index date | t-test | 0.2126 | Superiority |
| 3 months before index date | t-test | 0.7004 | Superiority |
| 3 months before index date | t-test | 0.1476 | Superiority |
| 3 months before index date | t-test | 0.2057 | Superiority |
| 4 months before index date | t-test | 0.2905 | Superiority |
| 4 months before index date | t-test | 0.8273 | Superiority |
| 4 months before index date | t-test | 0.6270 | Superiority |
| 5 months before index date | t-test | 0.3256 | Superiority |
| 5 months before index date | t-test | 0.5631 | Superiority |
| 5 months before index date | t-test | 0.4491 | Superiority |
| 6 months before index date | t-test | 0.2009 | Superiority |
| 6 months before index date | t-test | 0.3011 | Superiority |
| 6 months before index date | t-test | 0.2065 | Superiority |
| 7 months before index date | t-test | 0.6098 | Superiority |
| 7 months before index date | t-test | 0.2586 | Superiority |
| 7 months before index date | t-test | 0.4074 | Superiority |
| 8 months before index date | t-test | 0.0345 | Superiority |
| 8 months before index date | t-test | 0.4377 | Superiority |
| 8 months before index date | t-test | 0.7191 | Superiority |
| 9 months before index date | t-test | 0.0199 | Superiority |
| 9 months before index date | t-test | 0.1032 | Superiority |
| 9 months before index date | t-test | 0.9040 | Superiority |
| 10 months before index date | t-test | 0.0316 | Superiority |
| 10 months before index date | t-test | 0.6748 | Superiority |
| 10 months before index date | t-test | 0.2679 | Superiority |
| 11 months before index date | t-test | 0.5010 | Superiority |
| 11 months before index date | t-test | 0.3228 | Superiority |
| 11 months before index date | t-test | 0.7881 | Superiority |
| 12 months before index date | t-test | 0.0876 | Superiority |
| 12 months before index date | t-test | 0.1226 | Superiority |
| 12 months before index date | t-test | 0.9753 | Superiority |
| 1 month after index date | t-test | 0.0336 | Superiority |
| 1 month after index date | t-test | 0.2551 | Superiority |
| 1 month after index date | t-test | 0.6189 | Superiority |
| 2 months after index date | t-test | 0.7051 | Superiority |
| 2 months after index date | t-test | 0.9775 | Superiority |
| 2 months after index date | t-test | 0.7643 | Superiority |
| 3 months after index date | t-test | 0.2953 | Superiority |
| 3 months after index date | t-test | 0.6257 | Superiority |
| 3 months after index date | t-test | 0.4753 | Superiority |
| 4 months after index date | t-test | 0.0926 | Superiority |
| 4 months after index date | t-test | 0.0013 | Superiority |
| 4 months after index date | t-test | 0.0065 | Superiority |
| 5 months after index date | t-test | 0.2212 | Superiority |
| 5 months after index date | t-test | 0.9688 | Superiority |
| 5 months after index date | t-test | 0.5647 | Superiority |
| 6 months after index date | t-test | 0.0023 | Superiority |
| 6 months after index date | t-test | 0.1142 | Superiority |
| 6 months after index date | t-test | 0.3842 | Superiority |
| 7 months after index date | t-test | 0.9097 | Superiority |
| 7 months after index date | t-test | 0.3885 | Superiority |
| 7 months after index date | t-test | 0.3834 | Superiority |
| 8 months after index date | t-test | 0.3075 | Superiority |
| 8 months after index date | t-test | 0.9075 | Superiority |
| 8 months after index date | t-test | 0.5993 | Superiority |
| 9 months after index date | t-test | 0.0775 | Superiority |
| 9 months after index date | t-test | 0.1536 | Superiority |
| 9 months after index date | t-test | 0.8553 | Superiority |
| 10 months after index date | t-test | 0.6295 | Superiority |
| 10 months after index date | t-test | 0.0551 | Superiority |
| 10 months after index date | t-test | 0.2215 | Superiority |
| 11 months after index date | t-test | 0.1948 | Superiority |
| 11 months after index date | t-test | 0.6621 | Superiority |
| 11 months after index date | t-test | 0.6629 | Superiority |
| 12 months after index date | t-test | 0.5699 | Superiority |
| 12 months after index date | t-test | 0.7105 | Superiority |
| 12 months after index date | t-test | 0.5965 | Superiority |