Effects of Nicotine Salt Aerosol on Cigarette Smokers

Effects of Nicotine Salt Aerosol on Cigarette Smokers

This grant compares the effects of cigarette smoking, protonated nicotine ("salt") aerosol through an Electronic Nicotine Delivery System (ENDS), and unprotonated nicotine aerosol through an ENDS on nicotine delivery, nicotine craving, and other outcomes in cigarette smokers.

The purpose of this study is to determine differences in nicotine delivery, user behavior, subjective effects, and physiological effects, when cigarette smokers use a nicotine "salt" (protonated) aerosol, relative to an unprotonated aerosol or their own brand of cigarettes.

Inclusion Criteria:

Participants must be:

• healthy (determined by self-report)
• between 21-55 years old
• wiling to provide informed consent
• able to attend lab and abstain from tobacco/nicotine as required and agree to use designated products according to study protocol
• cigarette smokers

Exclusion Criteria:

• Women if breast-feeding or test positive for pregnancy (by urinalysis) at screening

Some study details about eligibility criteria are purposely omitted at this time to preserve scientific integrity. Full details will be posted at the conclusion of the study.