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On day one, two groups of nine patients each will respectively recieve the tree daily meals (breakfast, Lunch and dinner) in a controled clinical setting. Group 1 will recieve a low-salycilate diet, and group 2 a high-salycilate diet. Two hours after each meal, urinary Leucotriene E4, FEV1, FVC, FEV1/FVC and total nasal resistance will be measured. On day 7, after clearance time, group 1 will recieve high-salycilate diet and group 2 low salycilate diet and the same measurements will be obtained.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group 1 | Experimental | Low salycilate diet on day one and High salycilate diet on day 7 |
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| Group 2 | Experimental | High salycilate diet on day one and Low salycilate diet on day 7 |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Low salycilate diet | Other | Each arm of the experimental group will be exposed to low and high concentrations of dietary salycilates and urinary LTE4, FEV1, FVC, FEV1/FVC and total inspiratory nasal resistance will be measured at basal level and then two hours after each of the 3 daily meals. |
| Measure | Description | Time Frame |
|---|---|---|
| Change from baseline in Urinary concentration of Leucotriene E4 (LTE4) | pg/ml of creatinine | Baseline-4-8-12 hours in day one and Baseline-4-8-12 hours in day 7 |
| Measure | Description | Time Frame |
|---|---|---|
| Change from baseline in Expiratory Volume in 1 second (FEV-1) | Percentage of referenced value | Baseline-4-8-12 hours and Baseline-4-8-12 hours in day 7 |
| Change from baseline in Vital Capacity (FVC) |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Instituto Nacional de Enfermedades Respiratorias | Mexico City | Mexico City | 14080 | Mexico |
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Percentage of referenced value
| Baseline-4-8-12 hours and Baseline-4-8-12 hours in day 7 |
| Change from baseline in the Relationship between FEV1/FVC | Percentage of referenced value | Baseline-4-8-12 hours and Baseline-4-8-12 hours in day 7 |
| Change from baseline in the total nasal resistance obtained by rhinometry | pascals/cm3/sec | Baseline-4-8-12 hours and Baseline-4-8-12 hours in day 7 |