Effects of a High or Low Salycilate Diet on Urinary LTE4 and Clinical Features in AERD

Effects of a High or Low Salycilate Diet on Urinary Leucotriene E4 Levels and Clinical Features in Patients With Aspirin Exacerbated Respiratory Disease

On day one, two groups of nine patients each will respectively recieve the tree daily meals (breakfast, Lunch and dinner) in a controled clinical setting. Group 1 will recieve a low-salycilate diet, and group 2 a high-salycilate diet. Two hours after each meal, urinary Leucotriene E4, FEV1, FVC, FEV1/FVC and total nasal resistance will be measured. On day 7, after clearance time, group 1 will recieve high-salycilate diet and group 2 low salycilate diet and the same measurements will be obtained.

Inclusion Criteria:

• Confirmed Aspirin exacerbated respiratory disease.
• Controled asthma
• No actual systemic corticosteroid treatment
• No antileucotriene treatment.

Exclusion Criteria:

• Patients who do not complete both phases of the study
• Patients unable to perform adecuate spyrometric testing
• Patients who present severe asthmatic reactions with high salycilate foods