MRI Study of Antidepressants in the Treatment of Refractory Functional Dyspepsia

Magnetic Resonance Imaging Study of Antidepressants in the Treatment of Refractory Functional Dyspepsia

In this study, diffusion tensor imaging（DTI）technique was used to evaluate the brain microstructures and connective white matter microstructures in patients with refractory FD, resting fMRI was used to evaluate the functional connectivity between hemispheres, and neuroimaging changes after antidepressant intervention were observed to explore the activation patterns of resting brain homeostasis-receptive network areas in patients with refractory FD. We aimed to explore microstructure of white matter and gray matter and functional connectivity between hemispheres to explain the therapeutic mechanism of antidepressants.

In this study, functional magnetic resonance imaging (fMRI) was used to investigate the abnormal activation patterns of brain regions in patients with refractory FD in resting state, and to observe the changes of brain functions after antidepressant treatment, in order to find scientific evidence for exploring the etiology, neuropathological mechanism and the mechanism of antidepressant treatment of refractory FD.

Inclusion Criteria:

• Age 18-60 years old, meeting the criteria for inclusion of refractory FD
• HP infection negative
• Right handedness

Exclusion Criteria:

• Antidepressant drug allergists
• History of gastroduodenal surgery;
• Researchers judged suicidal ideation.
• Women in pregnancy or lactation.
• Patients with uncorrected narrow angle glaucoma.
• There was a history of epileptic seizures.
• suffering from any serious or unstable medical disease or disease.
• Addiction to illicit drugs or alcohol and unwillingness to discontinue use during the study period.
• Patients can't express their complaints correctly and can't cooperate with the researcher.