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The aim of this 18 study analysis was to compare the effect of bioavailable stannous fluoride (SnF2) dentifrices when used up to 3 months on gingivitis relative to a positive or negative control dentifrice.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Stannous Fluoride Dentifrice | Twice daily brushing |
| |
| Positive Control Dentifrice | Twice daily brushing |
| |
| Negative Control Dentifrice | Twice daily brushing |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Stannous Fluoride Dentifrice | Drug | Experimental stannous fluoride (0.454%) dentifrice |
|
| Measure | Description | Time Frame |
|---|---|---|
| Number of Bleeding Sites | Change from baseline as measured on number of bleeding sites (gingival bleeding index or Loe Silness index). | Up to 12 Weeks |
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Subjects were excluded from this study for the following reasons;
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This meta-analysis includes healthy adult male and females with mild-moderate gingivitis.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Multiple P&G Investigation Clinical Sites | Cincinnati | Ohio | 45040 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31562774 | Derived | Biesbrock A, He T, DiGennaro J, Zou Y, Ramsey D, Garcia-Godoy F. The effects of bioavailable gluconate chelated stannous fluoride dentifrice on gingival bleeding: Meta-analysis of eighteen randomized controlled trials. J Clin Periodontol. 2019 Dec;46(12):1205-1216. doi: 10.1111/jcpe.13203. |
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| ID | Term |
|---|---|
| D005891 | Gingivitis |
| ID | Term |
|---|---|
| D007239 | Infections |
| D005882 | Gingival Diseases |
| D010510 | Periodontal Diseases |
| D009059 | Mouth Diseases |
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| Positive control dentifrice | Drug | Positive control dentifrice containing (0.3%) triclosan. |
|
| Negative control dentifrice | Drug | Negative control dentifrice containing either sodium fluoride (0.243%) or sodium monofluorophosphate (0.76%) |
|
| D009057 |
| Stomatognathic Diseases |