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Progressive multifocal leucoencephalopathy (PML) is a demyelinating disease caused by John Cunningham virus (JCV) reactivation. Numerous molecules have been overstated because there were inaccurately tested in non-rigorous clinical trial.
The objective is to draw lessons from repeatedly false hopes of unconfirmed PML treatments that might contribute to prescribing ineffective drugs on claimed efficacy in case reports or small series and by failing to respect the need for clinical trial evaluation before authorizing their widespread use.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Measure of overall survival | Other | Measure of overall survival among AR-PML (AIDS-related PML) patients, exposed or not to maraviroc (MVC), and immune reconstitution inflammatory syndrome (IRIS) onset. |
| Measure | Description | Time Frame |
|---|---|---|
| Overall survival (OS) | 8 years |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with AR-PML, exposed or not to maraviroc, as part of combined antiretroviral treatment (cART).
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| ID | Term |
|---|---|
| D000163 | Acquired Immunodeficiency Syndrome |
| D007968 | Leukoencephalopathy, Progressive Multifocal |
| D054019 | Immune Reconstitution Inflammatory Syndrome |
| ID | Term |
|---|---|
| D015658 | HIV Infections |
| D000086982 | Blood-Borne Infections |
| D003141 | Communicable Diseases |
| D007239 | Infections |
| D015229 | Sexually Transmitted Diseases, Viral |
| D012749 | Sexually Transmitted Diseases |
| D016180 | Lentivirus Infections |
| D012192 | Retroviridae Infections |
| D012327 | RNA Virus Infections |
| D014777 | Virus Diseases |
| D012897 | Slow Virus Diseases |
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
| D007153 | Immunologic Deficiency Syndromes |
| D007154 | Immune System Diseases |
| D018792 | Encephalitis, Viral |
| D020805 | Central Nervous System Viral Diseases |
| D002494 | Central Nervous System Infections |
| D000069544 | Infectious Encephalitis |
| D027601 | Polyomavirus Infections |
| D004266 | DNA Virus Infections |
| D004660 | Encephalitis |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D056784 | Leukoencephalopathies |
| D003711 | Demyelinating Diseases |
| D000090862 | Neuroinflammatory Diseases |
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