Platelet Transfusion in Sepsis Trial

Platelet Transfusion in Sepsis Trial (PlaTiSep)

Platelets are important mediators of an inflammatory response and a key component of the innate immune system to defend the human body against invading pathogens. However, little evidence exists regarding the number of platelets that should be used als transfusion threshold in septic patients. In this trial platelet transfusion will be performed with either <50000/µl or <20000/µl as a trigger.

Inclusion Criteria:

• Sepsis defined as alteration of SOFA score (Sepsis-related organ failure assessment score) >2 points (Sepsis-3 definition)
• platelet count <50.000/µl

Exclusion Criteria:

• Age less than 18 years
• patients with immune thrombocytopenia
• major bleeding in the last 72 hours or ongoing major bleeding
• patient, surrogate or physician not committed to full intensive care support
• pregnancy