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| ID | Type | Description | Link |
|---|---|---|---|
| NCI-2019-02655 | Registry Identifier | CTRP (Clinical Trial Reporting Program) | |
| 2015-0272 | Other Identifier | M D Anderson Cancer Center |
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| Name | Class |
|---|---|
| National Cancer Institute (NCI) | NIH |
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This trial uses an interview and a survey to gather information from cancer patients about the onset of their fever and the administration of antibiotics. Collecting information from patients may help doctors to assess the relationship between time to antibiotic administration and inhospital cause specific death, intensive care unit admission, hospital length of stay, and positive blood cultures.
PRIMARY OBJECTIVES:
I. To assess the prognostic value of the length of time between the time onset of fever and first antibiotic administration on cause specific 14 day mortality rate.
SECONDARY OBJECTIVES:
I. To assess the associations of the length of time between the time onset of fever and first antibiotic administration with intensive care unit (ICU) admission, ICU length of stay, length of hospitalization and percentage of patients with positive blood cultures.
OUTLINE:
Patients respond to a survey and participate in an interview with study staff about their fever and when they started feeling unwell.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Observational (interview, survey) | Patients respond to a survey and participate in an interview with study staff about their fever and when they started feeling unwell. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Interview | Other | Take part in interview |
| |
| Measure | Description | Time Frame |
|---|---|---|
| 14 day cause specific mortality rate | Will perform univariate logistic regression analysis to assess the effect of time to antibiotic administration on death 14 days post fever onset. Will build multivariate logistic regression model(s) to further assess the effect of time to antibiotic administration on death 14 days post fever onset adjusting for other potential confounders. | At 14 days |
| Measure | Description | Time Frame |
|---|---|---|
| Cause specific death | Up to 5 years | |
| Intensive care unit (ICU) admission rate | Up to 5 years | |
| ICU length of stay |
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IInclusion criteria:
--> 18 years of age
Exclusion Criteria:
--Age <18
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Patients at the University of Texas MD Anderson Cancer Center
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| Name | Affiliation | Role |
|---|---|---|
| Sai-ching Yeung, MD | M.D. Anderson Cancer Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| M D Anderson Cancer Center | Houston | Texas | 77030 | United States |
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| Label | URL |
|---|---|
| MD Anderson Cancer Center | View source |
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| ID | Term |
|---|---|
| D064147 | Febrile Neutropenia |
| D005334 | Fever |
| ID | Term |
|---|---|
| D009503 | Neutropenia |
| D000380 | Agranulocytosis |
| D007970 | Leukopenia |
| D000095542 | Cytopenia |
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| ID | Term |
|---|---|
| D007407 | Interviews as Topic |
| ID | Term |
|---|---|
| D003625 | Data Collection |
| D004812 | Epidemiologic Methods |
| D008919 | Investigative Techniques |
| D017531 | Health Care Evaluation Mechanisms |
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| Survey Administration |
| Other |
Respond to survey |
|
Linear regression model will be used to assess the multivariate relationship between time to antibiotic administration, patient demographic and clinical characteristics with ICU length of stay. |
| Up to 5 years |
| Length of hospitalization | Linear regression model will be used to assess the multivariate relationship between time to antibiotic administration, patient demographic and clinical characteristics with length of hospitalization. | Up to 5 years |
| Percentage of patients with positive blood cultures | Up to 5 years |
| D006402 |
| Hematologic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
| D007960 | Leukocyte Disorders |
| D001832 | Body Temperature Changes |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D011787 | Quality of Health Care |
| D017530 | Health Care Quality, Access, and Evaluation |
| D011634 | Public Health |
| D004778 | Environment and Public Health |