The aim of the study is the characterization of parameters from medical history, physical examination and diagnostics, which correlate with and could be used to predict diuretic efficacy.

This prospective observational study is conducted to identify and further isolate possible predictors for the efficacy of diuretics and to identify potential new predictors.

The study also observes if specific diuretic regimes (e.g. combination of loop diuretics and distal effective diuretics for sequential nephron blockade) have a greater diuretic effect. This is not yet proved.

The data of the study shall to help to determine criteria, allowing to choose an effective diuretic regime in different patient cohorts already at the beginning of therapy and to identify patients at high risk.

Inclusion Criteria:

• Age over 18 years.
• Edema (peripheral and/or pulmonal) of cardiac or renal genesis.

Exclusion Criteria:

• Persons who are in a dependency/employment relationship with the investigators.
• Accommodation in an institution by judicial or administrative order.
• Patients in need of ascites puncture and/or thoracentesis on admission day.

Inclusion of patients with edematous states of cardiac or renal genesis. Patients with liver cirrhosis and in need of ascites puncture and/or thoracentesis are excluded.