Effects of Intraoperative Esmolol on Post-mastectomy Pain Syndrome

Effects of Intraoperative Esmolol on Post-mastectomy Pain Syndrome: a Cross-sectional Study

Chronic postoperative pain is an entity that is usually neglected by anesthetists, but several studies show that the choice of anesthetic technique may interfere with this prevalence. Esmolol is a selective beta-blocker of ultra fast duration that has been studied as a perioperative venous adjuvant with antihyperalgesic and opioid sparing action. The investigators ventured the possibility of this anti-hyperalgesic effect attenuating the chronic pain syndrome post-mastectomy.

Inclusion Criteria:

- Patients previously submitted to the study Analgesic Effect of Intraoperative Esmolol in Mastectomies: a randomized placebo controlled trial

Exclusion Criteria:

• Patient aged less than 18 years and over 65 years;
• Patients who refuse to participate in the study;
• Patients with pulmonary disease;
• Patients with cardiac, renal or hepatic disease;
• Use of psychoactive drug;
• Patients with sinus bradycardia;
• Pregnant women;
• Patients with allergy to dipyrone, morphine;
• Patients with chronic pain prior to the surgical procedure;
• Patients with neurological disorders;
• Patients undergoing surgical resurfacing