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| ID | Type | Description | Link |
|---|---|---|---|
| 5U19HD089881 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| Adolescent Trials Network for HIV/AIDS Interventions | NETWORK |
| Adolescent and Young Adult Research (AYAR), CORE Center | UNKNOWN |
| Children's Hospital of Philadelphia | OTHER |
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A randomized three arm control trial to examine the efficacy of two distinct apps (LYNX and MyChoices) developed for young men who have sex with men (YMSM) compared to standard of care (SOC) information about HIV testing and PrEP (Pre-Exposure Prophylaxis).
COMPARE is part of the iTech NIH U19, which has an overall goal to develop innovative technology-focused interventions addressing the HIV prevention and care continuum for youth. In years 1-2 of the iTech grant, the investigators optimized and pilot tested using a similar study design and identical study outcomes, two distinct mobile apps called LYNX and MyChoices. Each app is designed to increase HIV testing and PrEP uptake among YMSM. In this study, the individual apps are being tested in this follow-on research study to evaluate for efficacy. YMSM will be randomized to receive either MyChoices, LYNX, or SOC. LYNX uses the Information-Motivation-Behavior Skills (IMB) model and is a highly interactive mobile app to promote accurate risk perception, increase HIV/STI testing, and linkage to PrEP. MyChoices is guided by the Social Cognitive Theory (SCT) model, is adapted from HealthMindr and developed using iterative feedback from youth refined to maximize acceptability among YMSM. It includes three major functions that are designed to promote self-efficacy, self-regulation, goal-setting and environmental influences to impact behavior change. The SOC includes information on HIV testing and PrEP with the provision of referrals to local HIV/STI testing and PrEP resources.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| LYNX | Experimental | LYNX is developed using IMB model and engages youth through entering sexual diary data, earning badges, and calculating a personalized sexual protection (Sex Pro) score, which informs and motivates youth around HIV/STI testing and PrEP uptake. Behavioral skills are built through HIV/STI testing reminders, presenting options for home HIV testing and/or linkage to nearby testing services, and access to an online chat with support for HIV/STI testing and PrEP referral. |
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| MyChoices | Experimental | MyChoices is adapted from an app for adult MSM, HealthMindr, developed using SCT. The app aims to increase HIV testing and PrEP uptake by increasing self- regulation, self-reflection, and self-efficacy around HIV testing and PrEP uptake. Brief surveys about sexual risk and protective health behaviors within the app are used to assist users in tracking and self-monitoring their behaviors and creating a personalized HIV testing plan. Quizzes, videos and infographics as well as "Help me Choose," "Ordering," and geofencing functions are used to maximize self-efficacy around HIV prevention and uptake of PrEP. |
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| Standard of Care | No Intervention | Provision of referrals to local HIV/STI testing and PrEP resources. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| LYNX | Behavioral | Access to the LYNX mobile app which includes the Sex Pro score tool, sex diary, badges, PrEP information and video testimonials, HIV/STI testing reminders and geo-location features, and asynchronous chat feature. |
| Measure | Description | Time Frame |
|---|---|---|
| Efficacy for HIV testing: Proportion who complete >= 1 HIV test | Proportion who complete >= 1 HIV test | 6 months post baseline |
| Efficacy for PrEP uptake: Proportion who uptake PrEP | Proportion who uptake PrEP | 6 months post baseline |
| Efficacy for STI testing: Proportion who complete >=1 STI test | Proportion who complete >=1 STI test | 6 months post baseline |
| Measure | Description | Time Frame |
|---|---|---|
| Efficacy for HIV testing: Proportion who complete >= 1 HIV test | Proportion who complete >= 1 HIV test | 12 months post baseline |
| Efficacy for PrEP uptake: Proportion who uptake PrEP | Proportion who uptake PrEP |
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Inclusion Criteria:
Exclusion Criteria:
Cisgender men
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| Name | Affiliation | Role |
|---|---|---|
| Albert Y Liu, MD, MPH | San Francisco Department of Public Health | Principal Investigator |
| Katie B Biello, PhD, MPH | Brown University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of South Florida, Infectious Diseases | Tampa | Florida | 33606 | United States | ||
| PRISM Health |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 39908084 | Derived | Biello KB, Mayer KH, Scott H, Valente PK, Hill-Rorie J, Buchbinder S, Ackah-Toffey L, Sullivan PS, Hightow-Weidman L, Liu AY. The Effects of MyChoices and LYNX Mobile Apps on HIV Testing and Pre-Exposure Prophylaxis Use by Young US Sexual Minority Men: Results From a National Randomized Controlled Trial. JMIR Public Health Surveill. 2025 Feb 5;11:e63428. doi: 10.2196/63428. |
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Raw data will be available to outside individuals through contacting the multiple principal investigators (MPIs) at two different times. The first will be after all of the baseline data is collected. The investigators will institute a concept plan process where internal study staff first have the availability to write primary papers or give presentations on particular topics. After this, if outside individuals wish to analyze data, the investigators will welcome this collaboration. A similar process will happen for outcome data; however this will not be possible until the publication and release of the outcome paper(s). Information regarding the availability of data for analysis will be listed on the MPIs' web pages. Contact information for the MPIs will be listed in all manuscripts and publications as another means to access data.
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| ID | Term |
|---|---|
| D000163 | Acquired Immunodeficiency Syndrome |
| D012749 | Sexually Transmitted Diseases |
| D040242 | Risk Reduction Behavior |
| ID | Term |
|---|---|
| D015658 | HIV Infections |
| D000086982 | Blood-Borne Infections |
| D003141 | Communicable Diseases |
| D007239 | Infections |
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| Baylor College of Medicine |
| OTHER |
| University of South Florida | OTHER |
| Emory University | OTHER |
| Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | NIH |
| Fenway Community Health | OTHER |
| San Francisco Department of Public Health | OTHER_GOV |
| University of North Carolina, Chapel Hill | OTHER |
| Children's Hospital at Montefiore | OTHER |
| National Institute on Drug Abuse (NIDA) | NIH |
| National Institute of Mental Health (NIMH) | NIH |
| Brown University | OTHER |
| RAIN, Inc. | UNKNOWN |
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| MyChoices | Behavioral | Access to the MyChoices mobile app which includes the HIV test plan with reminders, STI information, PrEP resources, links to testing and PrEP sites, and geo-location features. |
|
| 12 months post baseline |
| Efficacy for STI testing: Proportion who complete >=1 STI test | Proportion who complete >=1 STI test | 12 months post baseline |
| Atlanta |
| Georgia |
| 30322 |
| United States |
| Ayar @ Core | Chicago | Illinois | 60612 | United States |
| Fenway Health Center | Boston | Massachusetts | 02215 | United States |
| Montefiore Children's Hospital | The Bronx | New York | 10467 | United States |
| RAIN, Inc | Charlotte | North Carolina | 28202 | United States |
| Adolescent Initiative at Children's Hospital of Philadelphia | Philadelphia | Pennsylvania | 19104 | United States |
| Baylor College of Medicine | Houston | Texas | 77030 | United States |
| D015229 |
| Sexually Transmitted Diseases, Viral |
| D016180 | Lentivirus Infections |
| D012192 | Retroviridae Infections |
| D012327 | RNA Virus Infections |
| D014777 | Virus Diseases |
| D012897 | Slow Virus Diseases |
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
| D007153 | Immunologic Deficiency Syndromes |
| D007154 | Immune System Diseases |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D001519 | Behavior |