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The objective of this study is to evaluate the efficacy (changes in dentinal hypersensitivity) and safety (oral soft tissue evaluation) after use of one of four dentifrices in subjects with pre-existing hypersensitivity over an 11-week period.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Marketed stannous fluoride toothpaste | Active Comparator | Brush twice daily |
|
| Marketed potassium nitrate toothpaste | Active Comparator | Brush Twice Daily |
|
| Marketed sodium monofluorophosphate toothpaste | Placebo Comparator | Brush Twice Daily |
|
| Experimental dipotassium oxalate toothpaste | Experimental | Brush Twice Daily |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Dipotassium oxalate toothpaste | Device | Experimental dipotassium oxalate (3%) toothpaste |
|
| Measure | Description | Time Frame |
|---|---|---|
| Air Challenge | The Schiff Sensitivity Scale will be assessed for each test tooth via an evaporative air challenge. The examiner will record the Schiff Index score corresponding to the response to the air challenge. The Schiff Index Sensitivity scale is scored as follows- 0: tooth/subject did not respond to stimulus, 1: tooth/subject responds to stimulus, but does not request discontinuation of stimulus, 2: tooth/subject responds to stimulus and requests discontinuation or moves form stimulus, 3: tooth/subject responds to stimulus, considers stimulus to be painful, and requests discontinuation of the stimulus. The higher the Schiff score, the more sensitive the tooth. The least square mean will be calculated for this measure. | 4 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Baseline Air Challenge | The Schiff Sensitivity Scale will be assessed for each test tooth via an evaporative air challenge. The examiner will record the Schiff Index score corresponding to the response to the air challenge. The Schiff Index Sensitivity scale is scored as follows- 0: tooth/subject did not respond to stimulus, 1: tooth/subject responds to stimulus, but does not request discontinuation of stimulus, 2: tooth/subject responds to stimulus and requests discontinuation or moves form stimulus, 3: tooth/subject responds to stimulus, considers stimulus to be painful, and requests discontinuation of the stimulus. The higher the Schiff score, the more sensitive the tooth. |
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Inclusion Criteria:
Exclusion Criteria:
having taken anti-inflammatory, analgesic, or psychotropic drugs, chronically;
chronic medical debilitating disease associated with constant or intermittent episodes of daily pain;
any home-care bleaching, whitening products or have had a professional bleaching treatment within 4 weeks of the Baseline visit;
dental prophylaxis within 2 weeks prior to Baseline visit;
having received professional desensitizing treatment or having used over-the-counter desensitizing products within 6 weeks of the Baseline visit;
having periodontal surgery, orthodontic treatment, or teeth restored in the preceding three months;
having teeth or periodontium with pathology or defects likely to cause pain;
having a history of allergies or hypersensitivity to ingredients in commercial dental products or cosmetics;
self-reported pregnancy or lactation;
having self-reported eating disorders, uncontrolled gastroesophageal reflux disease (GERD or Acid Reflux), excessive dietary or environmental exposure to acids, or other systemic conditions that are predisposing to dentinal hypersensitivity;
history or presence of kidney disorders, kidney stones, have celiac disease, inflammatory bowel disease (ulcerative colitis or Crohn's disease), chronic pancreatitis, have had intestinal or weight-loss surgery, or if have stomach or intestinal problems that keep them from absorbing certain foods or nutrients;
any diseases or condition that might interfere with the safe participation in the study;
inability to undergo study procedures;
having severe xerostomia;
having had active caries within the 12 months;
having high risk for caries development (rampant caries, multiple dental restorations, crowns with compromised margin) per examiners discretion;
teeth will be excluded from study measurements if they:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Silverstone Research Group | Las Vegas | Nevada | 89146 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40444818 | Derived | Biesbrock AR, He T, Zou Y, Grender JM, Amini P, Sagel PA, Groth A, Klukowska M. Randomized clinical trial evaluating kinetic benefits of desensitizing agents: Magnitude, onset, and stability of relief. J Periodontol. 2025 Dec;96(12):1339-1351. doi: 10.1002/JPER.24-0688. Epub 2025 May 30. |
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| ID | Title | Description |
|---|---|---|
| FG000 | Marketed Stannous Fluoride Toothpaste | Brush twice daily Stannous fluoride toothpaste: Marketed stannous fluoride (0.454%) toothpaste |
| FG001 | Marketed Potassium Nitrate Toothpaste |
| Title | Milestones | Reasons Not Completed | |||||
|---|---|---|---|---|---|---|---|
| Overall Study |
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| Prot_SAP | Yes | Yes | No | Study Protocol and Statistical Analysis Plan | May 23, 2019 |
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| Stannous fluoride toothpaste | Drug | Marketed stannous fluoride (0.454%) toothpaste |
|
| Potassium nitrate toothpaste | Drug | Marketed potassium nitrate (5%) toothpaste |
|
| Sodium monofluorophosphate toothpaste | Drug | Marketed sodium monofluorophosphate (0.76%) toothpaste |
|
| Baseline |
| Air Challenge | The Schiff Sensitivity Scale will be assessed for each test tooth via an evaporative air challenge. The examiner will record the Schiff Index score corresponding to the response to the air challenge. The Schiff Index Sensitivity scale is scored as follows- 0: tooth/subject did not respond to stimulus, 1: tooth/subject responds to stimulus, but does not request discontinuation of stimulus, 2: tooth/subject responds to stimulus and requests discontinuation or moves form stimulus, 3: tooth/subject responds to stimulus, considers stimulus to be painful, and requests discontinuation of the stimulus. The higher the Schiff score, the more sensitive the tooth. The least square mean will be calculated for this measure. | 3 days |
| Air Challenge | The Schiff Sensitivity Scale will be assessed for each test tooth via an evaporative air challenge. The examiner will record the Schiff Index score corresponding to the response to the air challenge. The Schiff Index Sensitivity scale is scored as follows- 0: tooth/subject did not respond to stimulus, 1: tooth/subject responds to stimulus, but does not request discontinuation of stimulus, 2: tooth/subject responds to stimulus and requests discontinuation or moves form stimulus, 3: tooth/subject responds to stimulus, considers stimulus to be painful, and requests discontinuation of the stimulus. The higher the Schiff score, the more sensitive the tooth. The least square mean will be calculated for this measure. | 2 weeks |
| Air Challenge | The Schiff Sensitivity Scale will be assessed for each test tooth via an evaporative air challenge. The examiner will record the Schiff Index score corresponding to the response to the air challenge. The Schiff Index Sensitivity scale is scored as follows- 0: tooth/subject did not respond to stimulus, 1: tooth/subject responds to stimulus, but does not request discontinuation of stimulus, 2: tooth/subject responds to stimulus and requests discontinuation or moves form stimulus, 3: tooth/subject responds to stimulus, considers stimulus to be painful, and requests discontinuation of the stimulus. The higher the Schiff score, the more sensitive the tooth. The least square mean will be calculated for this measure. | 8 weeks |
| Air Challenge | The Schiff Sensitivity Scale will be assessed for each test tooth via an evaporative air challenge. The examiner will record the Schiff Index score corresponding to the response to the air challenge. The Schiff Index Sensitivity scale is scored as follows- 0: tooth/subject did not respond to stimulus, 1: tooth/subject responds to stimulus, but does not request discontinuation of stimulus, 2: tooth/subject responds to stimulus and requests discontinuation or moves form stimulus, 3: tooth/subject responds to stimulus, considers stimulus to be painful, and requests discontinuation of the stimulus. The higher the Schiff score, the more sensitive the tooth. The least square mean will be calculated for this measure. All subjects will have been on three weeks use of a marketed sodium monofluophosphate toothpaste (from week 8 to week 11). | 11 weeks |
| Baseline Yeaple Probe | Tactile Threshold will be measured using a Yeaple probe. Testing is performed beginning at 10 g. The examiner records tactile scores for responding teeth. After treatment, testing begins at 10 g and increases by 10 g to a maximum of 50 g. The higher the tactile threshold, the less sensitive the tooth. Each successive challenge increases until a "yes" response is repeated. If a second "yes" is not obtained, the force setting is increased to the next step and continued until a force is found which elicits two consecutive "yes" responses and will be recorded as the threshold on the Tactile Sensitivity Score form. | Baseline |
| Tactile Threshold | Tactile Threshold will be measured using a Yeaple probe. Testing is performed beginning at 10 g. The examiner records tactile scores for responding teeth. After treatment, testing begins at 10 g and increases by 10 g to a maximum of 50 g. The higher the tactile threshold, the less sensitive the tooth. Each successive challenge increases until a "yes" response is repeated. If a second "yes" is not obtained, the force setting is increased to the next step and continued until a force is found which elicits two consecutive "yes" responses and will be recorded as the threshold on the Tactile Sensitivity Score form. The least square mean will be calculated for this measure. | 3 days |
| Tactile Threshold | Tactile Threshold will be measured using a Yeaple probe. Testing is performed beginning at 10 g. The examiner records tactile scores for responding teeth. After treatment, testing begins at 10 g and increases by 10 g to a maximum of 50 g. The higher the tactile threshold, the less sensitive the tooth. Each successive challenge increases until a "yes" response is repeated. If a second "yes" is not obtained, the force setting is increased to the next step and continued until a force is found which elicits two consecutive "yes" responses and will be recorded as the threshold on the Tactile Sensitivity Score form. The least square mean will be calculated for this measure. | 2 weeks |
| Tactile Threshold | Tactile Threshold will be measured using a Yeaple probe. Testing is performed beginning at 10 g. The examiner records tactile scores for responding teeth. After treatment, testing begins at 10 g and increases by 10 g to a maximum of 50 g. The higher the tactile threshold, the less sensitive the tooth. Each successive challenge increases until a "yes" response is repeated. If a second "yes" is not obtained, the force setting is increased to the next step and continued until a force is found which elicits two consecutive "yes" responses and will be recorded as the threshold on the Tactile Sensitivity Score form. The least square mean will be calculated for this measure. | 4 weeks |
| Tactile Threshold | Tactile Threshold will be measured using a Yeaple probe. Testing is performed beginning at 10 g. The examiner records tactile scores for responding teeth. After treatment, testing begins at 10 g and increases by 10 g to a maximum of 50 g. The higher the tactile threshold, the less sensitive the tooth. Each successive challenge increases until a "yes" response is repeated. If a second "yes" is not obtained, the force setting is increased to the next step and continued until a force is found which elicits two consecutive "yes" responses and will be recorded as the threshold on the Tactile Sensitivity Score form. The least square mean will be calculated for this measure. | 8 weeks |
| Tactile Threshold | Tactile Threshold will be measured using a Yeaple probe. Testing is performed beginning at 10 g. The examiner records tactile scores for responding teeth. After treatment, testing begins at 10 g and increases by 10 g to a maximum of 50 g. The higher the tactile threshold, the less sensitive the tooth. Each successive challenge increases until a "yes" response is repeated. If a second "yes" is not obtained, the force setting is increased to the next step and continued until a force is found which elicits two consecutive "yes" responses and will be recorded as the threshold on the Tactile Sensitivity Score form. The least square mean will be calculated for this measure. All subjects will have been on three weeks use of a marketed sodium monofluorophosphate toothpaste (from week 8 to week 11). | 11 weeks |
Brush Twice Daily
Potassium nitrate toothpaste: Marketed potassium nitrate (5%) toothpaste
| FG002 | Marketed Sodium Monofluorophosphate Toothpaste | Brush Twice Daily Sodium monofluorophosphate toothpaste: Marketed sodium monofluorophosphate (0.76%) toothpaste |
| FG003 | Experimental Dipotassium Oxalate Toothpaste | Brush Twice Daily Dipotassium oxalate toothpaste: Experimental dipotassium oxalate (3%) toothpaste |
| COMPLETED |
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| NOT COMPLETED |
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| ID | Title | Description |
|---|---|---|
| BG000 | Marketed Stannous Fluoride Toothpaste | Brush twice daily Stannous fluoride toothpaste: Marketed stannous fluoride (0.454%) toothpaste |
| BG001 | Marketed Potassium Nitrate Toothpaste | Brush Twice Daily Potassium nitrate toothpaste: Marketed potassium nitrate (5%) toothpaste |
| BG002 | Marketed Sodium Monofluorophosphate Toothpaste | Brush Twice Daily Sodium monofluorophosphate toothpaste: Marketed sodium monofluorophosphate (0.76%) toothpaste |
| BG003 | Experimental Dipotassium Oxalate Toothpaste | Brush Twice Daily Dipotassium oxalate toothpaste: Experimental dipotassium oxalate (3%) toothpaste |
| BG004 | Total | Total of all reporting groups |
| Units | Counts |
|---|---|
| Participants |
|
| Title | Description | Population Description | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Denominator Units Selected | Denominators | Classes | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Age, Continuous | Mean | Standard Deviation | years |
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| Sex: Female, Male | Count of Participants | Participants |
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| Ethnicity (NIH/OMB) | Count of Participants | Participants |
| ||||||||||||||||
| Race (NIH/OMB) | Count of Participants | Participants |
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| Type | Title | Description | Population Description | Reporting Status | Anticipated Posting Date | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Time Frame | Units Analyzed | Denominator Units Selected | Arm/Group Information | Denominators | Classes | Analyses | |||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Primary | Air Challenge | The Schiff Sensitivity Scale will be assessed for each test tooth via an evaporative air challenge. The examiner will record the Schiff Index score corresponding to the response to the air challenge. The Schiff Index Sensitivity scale is scored as follows- 0: tooth/subject did not respond to stimulus, 1: tooth/subject responds to stimulus, but does not request discontinuation of stimulus, 2: tooth/subject responds to stimulus and requests discontinuation or moves form stimulus, 3: tooth/subject responds to stimulus, considers stimulus to be painful, and requests discontinuation of the stimulus. The higher the Schiff score, the more sensitive the tooth. The least square mean will be calculated for this measure. | Posted | Least Squares Mean | Standard Error | score on a scale | 4 weeks |
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| Secondary | Baseline Air Challenge | The Schiff Sensitivity Scale will be assessed for each test tooth via an evaporative air challenge. The examiner will record the Schiff Index score corresponding to the response to the air challenge. The Schiff Index Sensitivity scale is scored as follows- 0: tooth/subject did not respond to stimulus, 1: tooth/subject responds to stimulus, but does not request discontinuation of stimulus, 2: tooth/subject responds to stimulus and requests discontinuation or moves form stimulus, 3: tooth/subject responds to stimulus, considers stimulus to be painful, and requests discontinuation of the stimulus. The higher the Schiff score, the more sensitive the tooth. | Posted | Mean | Standard Deviation | score on a scale | Baseline |
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| Secondary | Air Challenge | The Schiff Sensitivity Scale will be assessed for each test tooth via an evaporative air challenge. The examiner will record the Schiff Index score corresponding to the response to the air challenge. The Schiff Index Sensitivity scale is scored as follows- 0: tooth/subject did not respond to stimulus, 1: tooth/subject responds to stimulus, but does not request discontinuation of stimulus, 2: tooth/subject responds to stimulus and requests discontinuation or moves form stimulus, 3: tooth/subject responds to stimulus, considers stimulus to be painful, and requests discontinuation of the stimulus. The higher the Schiff score, the more sensitive the tooth. The least square mean will be calculated for this measure. | Posted | Least Squares Mean | Standard Error | score on a scale | 3 days |
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| Secondary | Air Challenge | The Schiff Sensitivity Scale will be assessed for each test tooth via an evaporative air challenge. The examiner will record the Schiff Index score corresponding to the response to the air challenge. The Schiff Index Sensitivity scale is scored as follows- 0: tooth/subject did not respond to stimulus, 1: tooth/subject responds to stimulus, but does not request discontinuation of stimulus, 2: tooth/subject responds to stimulus and requests discontinuation or moves form stimulus, 3: tooth/subject responds to stimulus, considers stimulus to be painful, and requests discontinuation of the stimulus. The higher the Schiff score, the more sensitive the tooth. The least square mean will be calculated for this measure. | Posted | Least Squares Mean | Standard Error | score on a scale | 2 weeks |
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| Secondary | Air Challenge | The Schiff Sensitivity Scale will be assessed for each test tooth via an evaporative air challenge. The examiner will record the Schiff Index score corresponding to the response to the air challenge. The Schiff Index Sensitivity scale is scored as follows- 0: tooth/subject did not respond to stimulus, 1: tooth/subject responds to stimulus, but does not request discontinuation of stimulus, 2: tooth/subject responds to stimulus and requests discontinuation or moves form stimulus, 3: tooth/subject responds to stimulus, considers stimulus to be painful, and requests discontinuation of the stimulus. The higher the Schiff score, the more sensitive the tooth. The least square mean will be calculated for this measure. | Posted | Least Squares Mean | Standard Error | score on a scale | 8 weeks |
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| Secondary | Air Challenge | The Schiff Sensitivity Scale will be assessed for each test tooth via an evaporative air challenge. The examiner will record the Schiff Index score corresponding to the response to the air challenge. The Schiff Index Sensitivity scale is scored as follows- 0: tooth/subject did not respond to stimulus, 1: tooth/subject responds to stimulus, but does not request discontinuation of stimulus, 2: tooth/subject responds to stimulus and requests discontinuation or moves form stimulus, 3: tooth/subject responds to stimulus, considers stimulus to be painful, and requests discontinuation of the stimulus. The higher the Schiff score, the more sensitive the tooth. The least square mean will be calculated for this measure. All subjects will have been on three weeks use of a marketed sodium monofluophosphate toothpaste (from week 8 to week 11). | Posted | Least Squares Mean | Standard Error | score on a scale | 11 weeks |
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| Secondary | Baseline Yeaple Probe | Tactile Threshold will be measured using a Yeaple probe. Testing is performed beginning at 10 g. The examiner records tactile scores for responding teeth. After treatment, testing begins at 10 g and increases by 10 g to a maximum of 50 g. The higher the tactile threshold, the less sensitive the tooth. Each successive challenge increases until a "yes" response is repeated. If a second "yes" is not obtained, the force setting is increased to the next step and continued until a force is found which elicits two consecutive "yes" responses and will be recorded as the threshold on the Tactile Sensitivity Score form. | Posted | Mean | Standard Deviation | score on a scale | Baseline |
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| Secondary | Tactile Threshold | Tactile Threshold will be measured using a Yeaple probe. Testing is performed beginning at 10 g. The examiner records tactile scores for responding teeth. After treatment, testing begins at 10 g and increases by 10 g to a maximum of 50 g. The higher the tactile threshold, the less sensitive the tooth. Each successive challenge increases until a "yes" response is repeated. If a second "yes" is not obtained, the force setting is increased to the next step and continued until a force is found which elicits two consecutive "yes" responses and will be recorded as the threshold on the Tactile Sensitivity Score form. The least square mean will be calculated for this measure. | Posted | Least Squares Mean | Standard Error | score on a scale | 3 days |
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| Secondary | Tactile Threshold | Tactile Threshold will be measured using a Yeaple probe. Testing is performed beginning at 10 g. The examiner records tactile scores for responding teeth. After treatment, testing begins at 10 g and increases by 10 g to a maximum of 50 g. The higher the tactile threshold, the less sensitive the tooth. Each successive challenge increases until a "yes" response is repeated. If a second "yes" is not obtained, the force setting is increased to the next step and continued until a force is found which elicits two consecutive "yes" responses and will be recorded as the threshold on the Tactile Sensitivity Score form. The least square mean will be calculated for this measure. | Posted | Least Squares Mean | Standard Error | score on a scale | 2 weeks |
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| Secondary | Tactile Threshold | Tactile Threshold will be measured using a Yeaple probe. Testing is performed beginning at 10 g. The examiner records tactile scores for responding teeth. After treatment, testing begins at 10 g and increases by 10 g to a maximum of 50 g. The higher the tactile threshold, the less sensitive the tooth. Each successive challenge increases until a "yes" response is repeated. If a second "yes" is not obtained, the force setting is increased to the next step and continued until a force is found which elicits two consecutive "yes" responses and will be recorded as the threshold on the Tactile Sensitivity Score form. The least square mean will be calculated for this measure. | Posted | Least Squares Mean | Standard Error | score on a scale | 4 weeks |
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| Secondary | Tactile Threshold | Tactile Threshold will be measured using a Yeaple probe. Testing is performed beginning at 10 g. The examiner records tactile scores for responding teeth. After treatment, testing begins at 10 g and increases by 10 g to a maximum of 50 g. The higher the tactile threshold, the less sensitive the tooth. Each successive challenge increases until a "yes" response is repeated. If a second "yes" is not obtained, the force setting is increased to the next step and continued until a force is found which elicits two consecutive "yes" responses and will be recorded as the threshold on the Tactile Sensitivity Score form. The least square mean will be calculated for this measure. | Posted | Least Squares Mean | Standard Error | score on a scale | 8 weeks |
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| Secondary | Tactile Threshold | Tactile Threshold will be measured using a Yeaple probe. Testing is performed beginning at 10 g. The examiner records tactile scores for responding teeth. After treatment, testing begins at 10 g and increases by 10 g to a maximum of 50 g. The higher the tactile threshold, the less sensitive the tooth. Each successive challenge increases until a "yes" response is repeated. If a second "yes" is not obtained, the force setting is increased to the next step and continued until a force is found which elicits two consecutive "yes" responses and will be recorded as the threshold on the Tactile Sensitivity Score form. The least square mean will be calculated for this measure. All subjects will have been on three weeks use of a marketed sodium monofluorophosphate toothpaste (from week 8 to week 11). | Posted | Least Squares Mean | Standard Error | score on a scale | 11 weeks |
|
Adverse event data were collected for all 11 weeks of the study for each intervention.
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| ID | Title | Description | Deaths (Affected) | Deaths (At Risk) | Serious Events (Affected) | Serious Events (At Risk) | Other Events (Affected) | Other Events (At Risk) |
|---|---|---|---|---|---|---|---|---|
| EG000 | Marketed Stannous Fluoride Toothpaste | Brush twice daily Stannous fluoride toothpaste: Marketed stannous fluoride (0.454%) toothpaste | 0 | 30 | 0 | 30 | 0 | 30 |
| EG001 | Marketed Potassium Nitrate Toothpaste | Brush Twice Daily Potassium nitrate toothpaste: Marketed potassium nitrate (5%) toothpaste | 0 | 30 | 0 | 30 | 5 | 30 |
| EG002 | Marketed Sodium Monofluorophosphate Toothpaste | Brush Twice Daily Sodium monofluorophosphate toothpaste: Marketed sodium monofluorophosphate (0.76%) toothpaste | 0 | 30 | 0 | 30 | 0 | 30 |
| EG003 | Experimental Dipotassium Oxalate Toothpaste | Brush Twice Daily Dipotassium oxalate toothpaste: Experimental dipotassium oxalate (3%) toothpaste | 0 | 30 | 0 | 30 | 3 | 30 |
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| Term | Organ System | Source Vocabulary | Assessment Type | Notes | Statistical Information |
|---|---|---|---|---|---|
| Desquamation Mouth | Gastrointestinal disorders | Non-systematic Assessment |
| ||
| Mouth Injury | Gastrointestinal disorders | Non-systematic Assessment |
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PI should disclose plans to sponsor prior to public release.
| Title | Organization | Phone | Extension | |
|---|---|---|---|---|
| Clinical Trial Manager | Procter and Gamble | 513-622-2489 | peters.j.2@pg.com |
| Sep 30, 2020 |
| Prot_SAP_000.pdf |
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| ID | Term |
|---|---|
| D003807 | Dentin Sensitivity |
| ID | Term |
|---|---|
| D014076 | Tooth Diseases |
| D009057 | Stomatognathic Diseases |
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| Male |
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| Not Hispanic or Latino |
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| Unknown or Not Reported |
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| Asian |
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| Native Hawaiian or Other Pacific Islander |
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| Black or African American |
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| White |
|
| More than one race |
|
| Unknown or Not Reported |
|
| OG003 | Experimental Dipotassium Oxalate Toothpaste | Brush Twice Daily Dipotassium oxalate toothpaste: Experimental dipotassium oxalate (3%) toothpaste |
|
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| OG003 | Experimental Dipotassium Oxalate Toothpaste | Brush Twice Daily Dipotassium oxalate toothpaste: Experimental dipotassium oxalate (3%) toothpaste |
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| OG003 | Experimental Dipotassium Oxalate Toothpaste | Brush Twice Daily Dipotassium oxalate toothpaste: Experimental dipotassium oxalate (3%) toothpaste |
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| OG003 | Experimental Dipotassium Oxalate Toothpaste | Brush Twice Daily Dipotassium oxalate toothpaste: Experimental dipotassium oxalate (3%) toothpaste |
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Brush Twice Daily
Sodium monofluorophosphate toothpaste: Marketed sodium monofluorophosphate (0.76%) toothpaste
| OG003 | Experimental Dipotassium Oxalate Toothpaste | Brush Twice Daily Dipotassium oxalate toothpaste: Experimental dipotassium oxalate (3%) toothpaste |
|
|
| OG003 |
| Experimental Dipotassium Oxalate Toothpaste |
Brush Twice Daily Dipotassium oxalate toothpaste: Experimental dipotassium oxalate (3%) toothpaste |
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| OG003 | Experimental Dipotassium Oxalate Toothpaste | Brush Twice Daily Dipotassium oxalate toothpaste: Experimental dipotassium oxalate (3%) toothpaste |
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| OG003 | Experimental Dipotassium Oxalate Toothpaste | Brush Twice Daily Dipotassium oxalate toothpaste: Experimental dipotassium oxalate (3%) toothpaste |
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| OG003 | Experimental Dipotassium Oxalate Toothpaste | Brush Twice Daily Dipotassium oxalate toothpaste: Experimental dipotassium oxalate (3%) toothpaste |
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| OG003 | Experimental Dipotassium Oxalate Toothpaste | Brush Twice Daily Dipotassium oxalate toothpaste: Experimental dipotassium oxalate (3%) toothpaste |
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| OG003 | Experimental Dipotassium Oxalate Toothpaste | Brush Twice Daily Dipotassium oxalate toothpaste: Experimental dipotassium oxalate (3%) toothpaste |
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