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| Name | Class |
|---|---|
| Wilmar International Limited | UNKNOWN |
| National University of Singapore | OTHER |
| Agency for Science, Technology and Research | OTHER |
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To investigate the effects of two types of oil blends on blood lipid profile, glucose homeostasis, body composition, gut microflora and other markers of cardiometabolic disease risk in Chinese men and women with borderline hyperlipidemia
The primary aims of this study is to evaluate the effects of consumption of two separate blends of cooking oil, containing rice bran, flaxseed and sesame oils, for a period of 8 weeks, on blood total cholesterol, total triglycerides, low-density and high-density lipoprotein cholesterol and metabolism in borderline hyperlipidaemic, 50 to 70 years old, Chinese, male and postmenopausal female, as compared to refined olive oil. The secondary aims of the study is to evaluate the effect of the two separate blends of cooking oil on markers of cardiometabolic diseases risk (including body composition, glucose homeostasis, markers of oxidative stress and chronic inflammation) and changes in gut microbiota composition and function.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Refined olive oil (ROO) | Other | Control |
|
| Blended Oil 1 | Experimental | BO1, propriety blend of cooking oil containing rice bran, flaxseed and sesame oil blended at proportions different from 'Blended Oil 2 |
|
| Blended Oil 2 | Experimental | BO2, propriety blend of cooking oil containing rice bran, flaxseed and sesame oil blended at proportions different from 'Blended Oil 1 |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Refined olive oil (ROO) | Other | Consumption of chicken dishes made with ROO for a period of 8 weeks |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change from baseline serum total cholesterol | Blood will be collected in plain serum tubes after an overnight fast, centrifuged and frozen within 2 hours of collection | 8 weeks measured every 2 weeks |
| Change from baseline serum low density lipoprotein cholesterol | Blood will be collected in plain serum tubes after an overnight fast, centrifuged and frozen within 2 hours of collection | 8 weeks measured every 2 weeks |
| Change from baseline serum total high density lipoprotein cholesterol | Blood will be collected in plain serum tubes after an overnight fast, centrifuged and frozen within 2 hours of collection | 8 weeks measured every 2 weeks |
| Change from baseline serum total triglycerides | Blood will be collected in plain serum tubes after an overnight fast, centrifuged and frozen within 2 hours of collection | 8 weeks measured every 2 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Change from baseline of serum glucose | Blood will be collected in plain serum tubes after an overnight fast, centrifuged and frozen within 2 hours of collection | 8 weeks measured every 2 weeks |
| Change from baseline of serum insulin |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Clinical Nutrition Research Centre | Singapore | 117599 | Singapore |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 35548564 | Derived | Haldar S, Ponnalagu S, Osman F, Tay SL, Wong LH, Jiang YR, Leow MKS, Henry CJ. Increased Consumption of Unsaturated Fatty Acids Improves Body Composition in a Hypercholesterolemic Chinese Population. Front Nutr. 2022 Apr 25;9:869351. doi: 10.3389/fnut.2022.869351. eCollection 2022. | |
| 33188423 | Derived | Haldar S, Wong LH, Tay SL, Jacoby JJ, He P, Osman F, Ponnalagu S, Jiang YR, Lian HPR, Henry CJ. Two Blends of Refined Rice Bran, Flaxseed, and Sesame Seed Oils Affect the Blood Lipid Profile of Chinese Adults with Borderline Hypercholesterolemia to a Similar Extent as Refined Olive Oil. J Nutr. 2020 Dec 10;150(12):3141-3151. doi: 10.1093/jn/nxaa274. |
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| ID | Term |
|---|---|
| D006949 | Hyperlipidemias |
| ID | Term |
|---|---|
| D050171 | Dyslipidemias |
| D052439 | Lipid Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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| Blended Oil 1 (BO1) | Other | Consumption of chicken dishes made with BO1 for a period of 8 weeks |
|
| Blended Oil 2 (BO2) | Other | Consumption of chicken dishes made with BO2 for a period of 8 weeks |
|
Blood will be collected in plain serum tubes after an overnight fast, centrifuged and frozen within 2 hours of collection
| 8 weeks measured every 2 weeks |
| Change from baseline in plasma oxidised low density lipoprotein | Blood will be collected in EDTA tubes after an overnight fast, centrifuged and frozen within 2 hours of collectionBlood will be collected in EDTA tubes after an overnight fast, centrifuged and frozen within 2 hours of collection | For 8 weeks measured every 2 weeks |
| Change from baseline in plasma fructosamine | Blood will be collected in EDTA tubes after an overnight fast, centrifuged and frozen within 2 hours of collectionBlood will be collected in EDTA tubes after an overnight fast, centrifuged and frozen within 2 hours of collection | 8 weeks measured every 2 weeks |
| Change from baseline in plasma glycated albumin | Blood will be collected in EDTA tubes after an overnight fast, centrifuged and frozen within 2 hours of collectionBlood will be collected in EDTA tubes after an overnight fast, centrifuged and frozen within 2 hours of collection | 8 weeks measured every 2 weeks |
| Change from baseline in plasma C-reactive protein | Blood will be collected in EDTA tubes after an overnight fast, centrifuged and frozen within 2 hours of collectionBlood will be collected in EDTA tubes after an overnight fast, centrifuged and frozen within 2 hours of collection | 8 weeks measured every 2 weeks |
| Change from baseline in plasma Interleukin-6 | Blood will be collected in EDTA tubes after an overnight fast, centrifuged and frozen within 2 hours of collectionBlood will be collected in EDTA tubes after an overnight fast, centrifuged and frozen within 2 hours of collection | 8 weeks measured every 2 weeks |
| Change from baseline in plasma Interleukin-1β | Blood will be collected in EDTA tubes after an overnight fast, centrifuged and frozen within 2 hours of collectionBlood will be collected in EDTA tubes after an overnight fast, centrifuged and frozen within 2 hours of collection | 8 weeks measured every 2 weeks |
| Change from baseline in plasma Tumor necrosis factor-α | Blood will be collected in EDTA tubes after an overnight fast, centrifuged and frozen within 2 hours of collectionBlood will be collected in EDTA tubes after an overnight fast, centrifuged and frozen within 2 hours of collection | 8 weeks measured every 2 weeks |
| Change from baseline in body fat composition percentage | measured using DEXA (Dual-Energy X-ray Absorptiometry) | 8 weeks |
| Change from baseline in bone mineral density | measured using DEXA (Dual-Energy X-ray Absorptiometry) | 8 weeks |
| Change from baseline in blood pressure | Measured using Omron blood pressure monitor after an overnight fast in a seated posture, at rest. Blood pressure measured for a minimum of 3 times and the average of the final 2 readings were taken, ensuring that they were within 10 mmHg of each other. | 8 weeks measured every 2 weeks |
| Change from baseline in gut microflora composition | Assessed using gut metagenome and metatranscriptome profiling | 8 weeks measured on days14 and 56 |
| Change from baseline in gut microflora function | Assessed using gut metagenome and metatranscriptome profiling | 8 weeks measured on days14 and 56 |
| Change from baseline in Body weight | Body impedance assessments (BIA) | 8 weeks measured every 2 weeks |
| Change from baseline in segmental % body fat | Body impedance assessments (BIA) | 8 weeks measured every 2 weeks |
| Change in body circumference measures | Using measuring tape | 8 weeks measured every 2 weeks |