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Logistical difficulties in the department due to a lack of paramedical staff and dialysis space.
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The objective of the EQUODIA study is to evaluate the hemodynamic stability of hemodialysis with low dialysate flow in patients requiring emergency hemodialysis in the context of acute kidney injury or unscheduled end-stage renal disease, not in intensive care, compared to conventional triweekly high-flow hemodialysis.
Short daily hemodialysis has excellent hemodynamic tolerance, which has already been confirmed by clinical experience. This modality, commonly used in the patient's home through new machines allowing a low dialysate flow purification technique, can prove to be an innovative, effective and safe alternative for patients admitted for hemodialysis in an unscheduled situation (acute kidney injury, unscheduled end-stage renal disease not followed).
Up to now, no studies have evaluated the use of short daily hemodialysis with low dialysate flow in patients with acute kidney injury or unscheduled end-stage renal disease, requiring the initiation of emergency extra-renal purification.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Hemodialysis with low dialysate flow | Experimental |
| |
| Conventional triweekly high-flow hemodialysis | Active Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Hemodialysis with low dialysate flow | Device | Hemodialysis with low dialysate flow |
|
| Measure | Description | Time Frame |
|---|---|---|
| Number of hypotension episodes | Decrease of ≥ 20 mmHg systolic blood pressure in regard to pre-dialysis value, associated with symptoms such as abdominal pain, yawn, nausea, vomiting, cramps, anxiety, dizziness, malaise and/or loss of consciousness | During the first two weeks of dialysis |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Natalia TARGET, PH | CHD Vendée de la Roche sur Yon | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Centre Hospitalier Départemental Vendée | La Roche-sur-Yon | 85925 | France |
| Type | Date | Date Unknown |
|---|---|---|
| Release | Jul 18, 2024 | |
| Reset | Oct 11, 2024 | |
| Release | Oct 15, 2024 |
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| Conventional triweekly high-flow hemodialysis | Device | Conventional triweekly high-flow hemodialysis |
|
| Reset | Nov 27, 2024 |
| Release | Dec 18, 2024 |
| Reset | Jan 22, 2025 |
| Release | Feb 13, 2025 |
| Reset | Feb 28, 2025 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Jul 18, 2024 | Oct 11, 2024 | |||
| Oct 15, 2024 | Nov 27, 2024 | |||
| Dec 18, 2024 | Jan 22, 2025 | |||
| Feb 13, 2025 | Feb 28, 2025 |
| ID | Term |
|---|---|
| D058186 | Acute Kidney Injury |
| D007676 | Kidney Failure, Chronic |
| ID | Term |
|---|---|
| D051437 | Renal Insufficiency |
| D007674 | Kidney Diseases |
| D014570 | Urologic Diseases |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |
| D051436 | Renal Insufficiency, Chronic |
| D002908 | Chronic Disease |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D006435 | Renal Dialysis |
| ID | Term |
|---|---|
| D017582 | Renal Replacement Therapy |
| D013812 | Therapeutics |
| D016060 | Sorption Detoxification |
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