The purpose of this study is to describe the safety and efficacy of opicapone plus standard of care in elderly patients with PD in the real-world setting

This will be a multinational, multicentre, prospective non-interventional study in elderly patients with PD. Approximately 100 patients with PD will be recruited by specialists from approximately 37 sites in European countries. The total enrolment period will be one year, and each patient will be followed for up to one year after enrolment.

PD patients with end-of-dose motor fluctuations suitable for additional treatment optimization will be included in the study and split into 2 cohorts:

• Cohort 1: 50 patients; standard of care (including L-DOPA) + starting opicapone
• Cohort 2: 50 patients; standard of care (including L-DOPA Data will be collected at baseline (date of enrolment), 1 month, 3 months, 6 months, 9 months, and 12 months after enrolment.

This non-interventional study does not recommend the use of any specific treatments. Use of opicapone and of standard of care are only driven by the physician's decision.

Inclusion Criteria:

• Patient or legally acceptable representative willing and able to provide informed consent as mandated by local regulation
• Patient with clinical diagnosis of idiopathic PD (excluding non-idiopathic PD: atypical Parkinsonism, secondary [acquired or symptomatic] Parkinsonism, Parkinson-plus syndrome)
• Patient with age >=75 years at enrolment
• Patient with end-of-dose motor fluctuations suitable for additional treatment optimization

Exclusion Criteria:

• Patient concurrently participating in any clinical trial
• Patient who used tolcapone or opicapone previously
• For the patient who starts opicapone: concomitant treatment with entacapone or tolcapone is not allowed
• Patient with any contraindications to Ongentys use
• Patient with any concomitant medical condition that could interfere with study assessments

The study plans to recruit approximately 100 elderly PD patients from neurology clinics