Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| Mohamed El Sharkawy | UNKNOWN |
| Yomna Bayoumi | UNKNOWN |
| mohamed hisham gouda | UNKNOWN |
| Dina latif |
Not provided
Not provided
Not provided
Not provided
Not provided
Nowadays, more and more women embark on pregnancy with previous Caesarean scar. One in five pregnancies requires induction of labour. The use of non-pharmacological methods (methods without using medication) has been gaining popularity for women who are not good candidates, such as women with previous Caesarean scar, for induction with medications such as prostaglandin. Labour induction with prostaglandin carries a higher risk of uterine rupture and thus it is not routinely offered to women with previous Caesarean delivery in Cairo University Hospital. Non-pharmacological methods of induction of labour appear to be safe in women with previous Caesarean delivery. However, various methods are available and the efficacy among them remain in doubt.
In Cairo University Hospital, castor oil, which is a type of induction methods, is routinely offered to women with previous Caesarean delivery who require induction of labor. However, castor oil may not exert its labor induction effect immediately and the delivery may be delayed by up to 8 days. This may render a proportion of women resort to repeated Caesarean section for failed induction. Castor oil is traditionally given by midwives in order to induce labor.
The investigators are intent to recruit 70 healthy pregnant women with a history of previous one cesarean section and with no contraindication to trial of labor after cesarean . Women will be randomly and blindly divided into equal-sized intervention group and control group. Intervention group will be given a single dose 60 mL of castor oil in 140 mL of orange juice, while control group will be given a placebo with similar texture. Primary outcomes to be tested are the percentage of women entering active labor within 24 hours of castor oil or placebo administration and the number of successful vaginal deliveries after cesarean.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| castor oil group | Experimental | 60 mL of castor oil in 140 mL of orange juice |
|
| placebo group | Placebo Comparator | Patients will receive sunflower oil as a placebo |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Castor Oil | Drug | The intervention group will be given 60 mL of castor oil in 140 mL of orange juice |
|
| Measure | Description | Time Frame |
|---|---|---|
| Percentage of women entering active phase within 24 hours of administering castor oil/placebo | Actual time of delivery | two weeks |
| number of successful VBAC cases | number of successful cases who delivered vaginally | 24 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Neonatal apgar scores | Neonatal APGAR scores | 1 minute and 5 minute after delivery |
| Neonatal complications including hospitalization in NICU | Were there any admissions to NICU, what was the reason ? |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Obstetric indication for CS (either elective or emergency):
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Yomna Bayoumi, MD | Cairo University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| faculty of medicine Cairo university | Cairo | 11562 | Egypt |
Not provided
| ID | Term |
|---|---|
| D002368 | Castor Oil |
| ID | Term |
|---|---|
| D005224 | Fats, Unsaturated |
| D005223 | Fats |
| D008055 | Lipids |
| D010938 | Plant Oils |
| D009821 |
Not provided
Not provided
| UNKNOWN |
Not provided
Not provided
Not provided
Not provided
| placebo | Drug | the control group will be given a sunflower oil as a placebo with a similar texture to castor oil |
|
| immediately after birth |
| Mode of delivery (ie. Normal delivery Vs. Cesarean delivery) | Mode of delivery | Within two weeks of enrollment |
| duration of labor | duration of labor in hours | 24 hours |
| number of cases needing oxytocin augmentation | number of cases needing oxytocin augmentation | 24 hours |
| Oils |
| D028321 | Plant Preparations |
| D001688 | Biological Products |
| D045424 | Complex Mixtures |