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This study aims at comparing the effects of bilateral ultrasound-guided quadratus lumborum block versus lumbar epidural block on postoperative analgesia and inflammatory response following major lower abdominal cancer surgery.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| quadratus lumborum block | Active Comparator | received pre-emptive ultrasound-guided quadratus lumborum block with 25 mL of 0.25% bupivacaine on each side of the abdominal wall before induction of GA. |
|
| lumbar epideural block | Active Comparator | received pre-emptive lumbar epidural block with 15 mL of 0.25% bupivacaine before induction of GA. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Ultrasound quadratus lumborum block with bupivacaine 25% | Other | echogenic needle will be inserted in-plane with the ultrasound beam in a posterior-to-anterior direction through the quadratus lumborum muscle until the ventral fascia of the muscle penetrated. At this point, the needle directed toward the fascial plan between the quadratus lumborum and the Psoas muscle |
| Measure | Description | Time Frame |
|---|---|---|
| postoperative pain | postoperative pain intensity. | first 24 hours postoperatively |
| Measure | Description | Time Frame |
|---|---|---|
| postoperative inflammatory response | inflammatory response represented by the levels of: interleukins 1,6, and tumor necrosis factor alpha | first 24 hours postoperatively |
| side effects | sedation, nausea, vomiting, and respiratory depression |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Ahmad M Abd El-Rahman, M.D. | Contact | 00201149606060 | ahmad23679@gmail.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| South Egypt Cancer Institute | Recruiting | Asyut | 171516 | Egypt |
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| lumbar epideural block with bupivacaine 25% | Other | lumbar epidural will be performed for patients in group II using a 16-gauge Touhy epidural needle by a median approach. The T12 - L1 or L1 - L2 interspaces will be chosen for the injection. The epidural space identified by the loss of resistance technique. |
|
| first 24 hours postoperatively |
| ID | Term |
|---|---|
| D010149 | Pain, Postoperative |
| ID | Term |
|---|---|
| D011183 | Postoperative Complications |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D010146 | Pain |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
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