This study was conducted to investigate the effects of daily supplementation of deep sea water on improvement of hyperglycemia

This study was a 8 weeks, randomized, double-blind, placebo-controlled, cross-over clinical trial.

Inclusion Criteria:

• Fasting plasma glucose concentration of 100-140 mg/dL or 2h-postprandial plasma glucose concentration of 140 ~199 mg/dL

Exclusion Criteria:

• Patients with type 1 or type 2 diabetes

• HbA1c ≥9.0%

• Weight decreased by more than 10% within past 3 months

• Have clinically significant acute or chronic cardiovascular system, endocrine system, immune system, respiratory system, hepatic biliary system, kidney and Urinary system, neuropsychiatry, musculoskeletal, inflammatory and hematologic malignancies, gastrointestinal disorders, etc.

• Hypoglycemic agent, obesity medicine, lipid lowering agent within past 6 months or functional food within past 2 month

• Subjects who have taken corticosteroid within past 1 months

• History of alcohol or substance abuse

• Participation in any other clinical trials within past 2 months

• Laboratory test by show the following results

  • Serum AST (aspartate aminotransferase) or ALT (alanine aminotransferase) > 2 times the upper limit of normal range
  • Serum Creatinine > 2.0 mg/dl

• Pregnancy or breast feeding

• If a woman of childbearing doesn't accept the implementation of appropriate contraception

• Principal Investigator judged inappropriate for participation in study because of Laboratory test result, etc