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| Name | Class |
|---|---|
| Fundació Ictus | UNKNOWN |
| Pla Director de la Malaltia vascular Cerebral, Departament de Salut | UNKNOWN |
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A population-based registry in Catalonia of patients with acute spontaneous Intracerebral Hemorrhage, to investigate whether type of center and time from onset to admission is associated with functional outcome and mortality.
Introduction. Recent studies show that there are potentially beneficial therapeutic measures for the patient with acute intracerebral hemorrhage (ICH), which should be applied urgently and that some would only be available in tertiary stroke centers (TSC). However, the transportation criteria for ICH patients are not well defined.
Objectives: Design and implementation of a registry (HIC-CAT) of patients with HIC in the healthcare network of public hospitals in Catalonia, which does not modify the current logistics but collects data related to patients and TSC, interhospital transfers and non-TSC centers. The registry will allow us to evaluate the hypothesis that: 1) Patient care in TSC decreases the probability of death or dependence in patients with spontaneous ICH compared to non-TSC; and 2) The shorter the time until admission to a TSC, the better the survival and functional outcome. This will be due to the application of diagnostic, therapeutic and structural measures at the TSC. In addition, organ donation will be more frequent in a TSC.
Methods: Observational, prospective, multicentre, population study of 2500 consecutive patients with spontaneous ICH of less than 24 hours from the onset of symptoms and Rankin scale score 0-3. We will collect times, clinical and radiological variables, vital and functional outcome at 3 months follow-up. Number of organ donations. Primary variable: Functional outcome at 3 months (Rankin 0-3). Statistics: Multivariate analysis with logistic regression, propensity matching scores.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Type of center | Other | Tertiary versus non-tertiary |
|
| Measure | Description | Time Frame |
|---|---|---|
| Functional outcome | Rankin scale score, favourable if 0,1, 2 or 3 | 3 months after onset |
| Measure | Description | Time Frame |
|---|---|---|
| Mortality | mortality within the first 3 months after onset | 3 months |
| Hematoma expansion | increase in hematoma volume (>33% and/or 6 ml) from baseline CT to follow-up CT |
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Inclusion Criteria:
Exclusion Criteria:
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All patients with a diagnosis of acute spontaneous intracerebral hemorrhage in Catalonia during a period of 2 years
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Joan Martí-Fàbregas, MD,PhD | Contact | +34935565986 | jmarti@santpau.cat |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hospital Germans Trias i Pujol | Badalona | Barcelona | Spain | |||
| Fundació Hospital Asil Granollers |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41026995 | Derived | Lambea-Gil A, Marti-Fabregas J, Cardona P, Rodriguez-Luna D, Millan M, Amaro S, Prats-Sanchez L, Silva Y, Sero L, Rodriguez-Campello A, Canovas D, Martinez-Domeno A, Guasch-Jimenez M, Ezcurra-Diaz G, Carcel-Marquez J, Fernandez-Cadenas I, Perez De La Ossa N, Abilleira S, Salvat-Plana M, Fagundez O, Camps-Renom P, Ramos-Pachon A; as the HIC-CAT investigators. Effect of Onset-to-Admission Time and Care Bundle Achievement on Functional Outcomes in Patients With ICH: A Population-Based Study. Neurology. 2025 Oct 21;105(8):e214176. doi: 10.1212/WNL.0000000000214176. Epub 2025 Sep 30. | |
| 38875516 |
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| 72 hours |
| Stroke Unit admission | Percentage of patients admitted to a stroke unit | 3 months |
| Neurological worsening | increase in 4 or more points in the NIHSS score and/or decrease >1 point in the Glasgow coma scale score | During admission |
| Granollers |
| Barcelona |
| Spain |
| Hospital d'Igualada | Igualada | Barcelona | Spain |
| Hospital de Bellvitge | L'Hospitalet de Llobregat | Barcelona | Spain |
| Hospital de Mataró | Mataró | Barcelona | Spain |
| Hospital Parc Taulí | Sabadell | Barcelona | Spain |
| Hospital Moisés Broggi | Sant Joan Despí | Barcelona | Spain |
| Mutua de Terrassa | Terrassa | Barcelona | Spain |
| Hospital de Figueras | Figueras | Girona | Spain |
| Hospital de Palamós | Palamós | Girona | Spain |
| Fundació Sant hospital de la Seu d'Urgell | La Seu d'Urgell | Lleida | Spain |
| Hospital de Tremp | Tremp | Lleida | Spain |
| Hospital de la Cinta | Tortosa | Tarragona | Spain |
| Hospital de la Santa Creu i Sant Pau | Barcelona | 08025 | Spain |
| Consorci Sanitari del Garraf | Barcelona | Spain |
| Hospital Clínic | Barcelona | Spain |
| Hospital del Mar | Barcelona | Spain |
| Hospital Universitari Vall d'Hebron | Barcelona | Spain |
| Hospital Dr Josep Trueta | Girona | Spain |
| Hospital Arnau de Vilanova | Lleida | Spain |
| Hospital de la Cerdanya | Lleida | Spain |
| Centre Hospitalari Althaia | Manresa | Spain |
| Hospital Comarcal Móra d'Ebre | Móra d'Ebre | Spain |
| Hospital joan XXIII | Tarragona | Spain |
| Hospital de Vic | Vic | Spain |
| Hospital de Vilafranca | Vilafranca del Penedès | Spain |
| Derived |
| Marti-Fabregas J, Ramos-Pachon A, Prats-Sanchez L, Nunez-Guillen A, Rodriguez BL, Rodriguez-Luna D, Amaro S, Silva Y, Rodriguez-Campello A, Puig I, Gomez-Choco M, Vazquez-Justes D, Guanyabens N, Cocho D, Canovas D, Steinhauer EG, Llull L, Guasch-Jimenez M, Martinez-Domeno A, Marin R, Lambea-Gil A, Diaz GE, Paipa-Merchan A, Quesada H, Casadevall MP, Wenger D, Pancorbo O, Sero L, Perez J, Costa X, Zaragoza J, Rodriguez-Villatoro N, Catena E, Calvo NM, Krupinski J, De La Ossa NP, Abilleira S, Salvat-Planas M, Fagundez O, Camps-Renom P; for HIC-CAT. Influence of Hospital Type on Outcomes of Patients With Acute Spontaneous Intracerebral Hemorrhage: A Population-Based Study. Neurology. 2024 Jul 23;103(2):e209539. doi: 10.1212/WNL.0000000000209539. Epub 2024 Jun 14. |
| ID | Term |
|---|---|
| D002543 | Cerebral Hemorrhage |
| ID | Term |
|---|---|
| D020300 | Intracranial Hemorrhages |
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D006470 | Hemorrhage |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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