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In this study, it is aimed to compare the effects of cognitive exercises applied on long-term internet environment to the cognitive level of patients who received donepezil, memantine or donepezil / memantin combination therapy.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group A | Experimental | Donepezil/Memantin Combination |
|
| Group B | Experimental | Donepezil/Memantin Combination + Cognitive Exercises (BEYNEX Software) |
|
| Group C | Active Comparator | Donepezil Mono |
|
| Group D | Active Comparator | Donepezil Mono + Cognitive Exercises (BEYNEX Software) |
|
| Group E | Active Comparator | Memantine Mono |
|
| Group F | Active Comparator | Memantine Mono + Cognitive Exercises (BEYNEX Software) |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Ebicomb | Combination Product | Combination product and combination product plus cognitive exercises will primarily be evaluated in this study |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in MOCA total score | MOCA: Montreal - Cognitive Assessment | 6-months |
| Measure | Description | Time Frame |
|---|---|---|
| Change in GDS total score | GDS (The Geriatric Depression Scale) | 6-months |
| Change in ADAS-Cog total score | ADAS-Cog: Alzheimer's Disease Assessment Scale- Cognitive Subscale |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Neutec RD | Contact | 00908502012323 | 0000 | iremkaraman@neutecrdc.com |
| Name | Affiliation | Role |
|---|---|---|
| Türker Şahiner, Prof Dr | Project Consultant | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Maltepe University Hospital | Recruiting | Istanbul | Turkey (Türkiye) |
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| ID | Term |
|---|---|
| D000544 | Alzheimer Disease |
| ID | Term |
|---|---|
| D003704 | Dementia |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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| ID | Term |
|---|---|
| C000610194 | Namzaric |
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|
| 6-months |
| Change in CDR total score | CDR: The Clinical Dementia Rating | 6-months |
| Change in B-ADL total score | B-ADL: The Bayer Activities of Daily Living Scale | 6-months |
| Change in clock drawing test | The subject is asked to draw the face of a clock with all numbers and to set the hands for a specified time (hh:mm) and will be evaluated according to ability to draw. | 6-months |
| D024801 |
| Tauopathies |
| D019636 | Neurodegenerative Diseases |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |