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Retrospective analysis where patients with histologically confirmed Non-small cell lung cancer (NSCLC) were centrally evaluated for the presence of KRAS and EGFR mutations.
A retrospective analysis, performed by the Hellenic Co-operative Oncology Group (HeCOG), in samples from patients with histologically confirmed NSCLC, who had been treated within HeCOG-affiliated centres from March 2000 through December 2012, were centrally evaluated for the presence of KRAS and EGFR mutations. All patients had available clinicopathological data at diagnosis. Formalin-fixed, paraffin-embedded tissue blocks were retrospectively retrieved from the HeCOG tumor repository. Cytologic material was prospectively submitted for genotyping in more recent years (2010-2012).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| K-RAS and EGFR mutated | |||
| Wild type |
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| Measure | Description | Time Frame |
|---|---|---|
| Progression free survival | from the date of treatment start until verified disease progression, death from any cause or date of last contact whichever occurred first, up to 9 months | |
| Overall survival | from the date of treatment start until verified disease progression, death from any cause or date of last contact whichever occurred first, up to 36 months |
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Inclusion Criteria:
Exclusion Criteria: -
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Patients treated within HeCOG-affiliated centres from March 2000 through December 2012.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Oncology Unit, Metropolitan Hospital | Neo Faliro | Athens | 18547 | Greece |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
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| ID | Term |
|---|---|
| D002289 | Carcinoma, Non-Small-Cell Lung |
| ID | Term |
|---|---|
| D002283 | Carcinoma, Bronchogenic |
| D001984 | Bronchial Neoplasms |
| D008175 | Lung Neoplasms |
| D012142 | Respiratory Tract Neoplasms |
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Formalin- fixed paraffin- embedded tissue blocks.
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| D013899 |
| Thoracic Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |