Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
ADHD is a common disorder, leading to a significant disability that often persists in adulthood. ADHD is characterized by attentional disturbances that are difficult to asses with standard neuropsychological tests.
Attention tends to stall after a certain time of fatigue (i.e. an attention lapse). The aim of this study is to study the electroencephalographic (EEG) characteristics of these attention lapses in a sustained attention task, comparing ADHD patients with healthy subjects.
The main goal is to assess with EEG the timing of the attentional demobilization that precedes a sustained attention lapse in patients with ADHD.
The secondary objectives are: 1 / To analyze impaired cognitive control mechanisms during lapses in patients with ADHD; 2 / Study the relationships between the deficits identified through EEG recording, clinical evaluations, and the subjective perception of daily difficulties; 3 / To measure the impact of the subjective attention state on the neuronal precursors of the attentional lapses; 4 / Evaluate the relation between propensity to wandering mind and attentional lapses.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Adult ADHD | Adult ADHD patients without current comorbidity and treatment. |
| |
| Healthy controls | Healthy controls without ADH, paired in age and gender. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Electroencephalography during sustained attention task. | Other | The Continuous Temporal Expectancy Task (CTET) (O'Connell et al., 2009) is a very demanding discrimination task with sustained attention. It consists of the presentation on a computer screen of a visual pattern resembling a checkerboard that changes orientation at regular intervals of time. In this task the subject must respond (pressing a response button) to the appearance of rare target stimuli that have a longer duration (1120 ms) than non-target stimuli (800 ms). SART (Sustained Attention to Response Task) (Robertson et al., 1997) is a task of inhibition (Go / No-Go task) to evaluate the capacities of sustained attention. It consists in the successive and random presentation on a computer screen of the numbers from 1 to 9. In this task the subject must respond, by pressing a response button, to the appearance of all the numbers (very non-target stimuli frequent), with the exception of the number "3". |
| Measure | Description | Time Frame |
|---|---|---|
| Spectral amplitude of the alpha band (8-14 Hz) to the quantitative EEG during the period up to 20 seconds before the successful trials vs. missed trials (lapse). | In healthy subjects, EEG changes, including increased parieto-occipital activity in the alphas frequency band (8-14Hz), have been observed 20 seconds before lapse (O'Connell et al., 2009). The analysis of the evoked potentials associated with the stimuli presented just before the occurrence of the target stimulus, reveals that the amplitude of the P300 on the 5 trials preceding the target to be detected is significantly lower before an omission (lapse) than before a correct detection. | During EEG realized after the inclusion |
| Measure | Description | Time Frame |
|---|---|---|
| CNV difference between missed and successful trials | Time course analysis of electrophysiological markers (EEG) before an attention lapse : amplitude of the evoked potentials | During EEG realized after the inclusion |
| CNV difference between missed and successful trials |
Not provided
Inclusion Criteria:
For Healthy controls
Exclusion criteria:
Not provided
Not provided
Patients included in the ADHD group are patients assessed during a specialized consultation on adult ADHD This consultation corresponds to standard care, during which a clinical examination is performed, as well as an interview with the psychiatrist.
If the diagnosis of ADHD is confirmed, comorbidities are systematically sought and the eligibility criteria for inclusion of the patient in the study are verified.
Healthy control are recruited by advertising.
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Sébastien WEIBEL | Hôpitaux Universitaires de Strasbourg | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hôpital Civil - service de Psychiatrie 2 | Strasbourg | 67091 | France |
Not provided
| ID | Term |
|---|---|
| D001289 | Attention Deficit Disorder with Hyperactivity |
| ID | Term |
|---|---|
| D019958 | Attention Deficit and Disruptive Behavior Disorders |
| D065886 | Neurodevelopmental Disorders |
| D001523 | Mental Disorders |
Not provided
Not provided
Not provided
Not provided
Not provided
|
|
Time course analysis of electrophysiological markers (EEG) after a successful test: amplitude of the evoked potentials and theta power (intensity in μV). |
| During EEG realized after the inclusion |
| Association between EEG lapses markers, neuropsychological measures of attention, clinical scales and subjective mindwandering | Regression and correlation analyzes involving electrophysiological markers associated with attentional lapses (see main objective) | During EEG realized after the inclusion |
| Association between EEG lapses markers, neuropsychological measures of attention, clinical scales and subjective mindwandering | Regression and correlation analyzes involving electrophysiological markers associated with neuropsychological attention test scores (TAP) | During EEG realized after the inclusion |
| Association between EEG lapses markers, neuropsychological measures of attention, clinical scales and subjective mindwandering | Regression and correlation analyzes involving electrophysiological markers associated with clinical scales (self-report ASRS and WFIRS) | During EEG realized after the inclusion |
| Association between EEG lapses markers, neuropsychological measures of attention, clinical scales and subjective mindwandering | Regression and correlation analyzes involving electrophysiological markers associated with subjective measures of mind wandering (ad hoc questionnaire) | During EEG realized after the inclusion |
| EEG lapse markers according attentional subjective state | Frequency of lapses of attentional lapses (evoked potentials P3a and CNV, theta power) (intensity in μV), according to the attentional state described by the subjects during the evaluations during the task | During EEG realized after the inclusion |
| EEG lapse markers according attentional subjective state | amplitude electrophysiological markers (EEG) of attentional lapses (evoked potentials P3a and CNV, theta power) (intensity in μV), according to the attentional state described by the subjects during the evaluations during the task | During EEG realized after the inclusion |