Monitoring the Hyperammonaemia:TOXicity of Drugs (AmmoTOX)

Monitoring the Hyperammonaemia:TOXicity of Drugs (AmmoTOX)

Several drugs and chemotherapies seem to have an impact on the metabolic system. This study investigates reports of metabolic toxicities such as hyperammonemia, including the International classification of disease ICD-10 for treatments in the World Health Organization (WHO) global Individual Case Safety Report (ICSR) database (VigiBase).

Several drugs and chemotherapies seem to have an impact on the metabolic system and are responsible of a wide range of metabolical side effects such as hyperammonemia. Those are poorly described, due to the modification of the pharmacopeia, and the recent recognition of several of these adverse events. This study investigates the main characteristics of patients affected by metabolic side effects imputed to drugs in particular hyperammonemia. A causality assessment according to the WHO-UMC (World Health Organization - Uppsala Monitoring Center) is systematically applied.

Inclusion Criteria:

• Case reported in the WHO's pharmacovigilance database till 01/05/2019

Exclusion Criteria:

• Chronology not compatible between the drug and the toxicity