In recent years, an increased approach has appeared in the use of autologous blood products to assist tissue and organ healing. Application of platelet rich plasma (PRP) has emerged as a potential solution for infertile women with poor ovarian reserve in reproductive specialty.

Quantitative and qualitative functional improvement of ovarian function has been reported in several studies after using autologous PRP in a reproductive field. Ovarian rejuvenation, stimulating the ovaries to produce new eggs after injecting PRP, can offer hope for renewed fertility to women with poor reserve volume, advanced maternal age, or either naturally occurring or premature menopause. But, these encouraging results should be supported by several new studies.

This study aimed to estimate the efficacy of trans-vaginal ovarian injection with PRP in rejuvenates ovaries in woman with poor ovarian reserve, and to assess any association of some women variables (age, menstrual status, parity, BMI) as predicting factors in success of ovarian injection with PRP.

Inclusion Criteria:

1. Menopause or peri-menopause under the age of 50.
2. Premature ovarian insufficiency which is ovarian failure before the age of 40.
3. Woman with primary ovarian failure of any cause.

Exclusion Criteria:

1. A previous injection with any medication, plasma, or PRP
2. Invisible or difficult access ovaries.
3. Medical disease or unfit for anesthesia patient.

Infertile women

All data will be managed confidentially