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Central Nervous System (CNS) demyelinating conditions include multiple sclerosis (MS), Acute Disseminated Encephalomyelitis (ADEM), Neuromyelitis Optica Spectrum Disorder (NMOSD), Optic Neuritis (ON) and Transverse Myelitis (TM). The symptoms of these conditions are quite variable from patient to patient, but can include motor, sensory, visual, gait and cognitive changes. Conventional MRI can be used to look for new anatomic changes, but fails to measure underlying biochemical changes in brain tissue. The purposes of this study are to identify the biologic and anatomic correlations between cognitive profiles and disease activity using MRI imaging techniques.
Pediatric patients (age 12 to 21 inclusive) with a diagnosis of multiple sclerosis, ADEM, anti-MOG mediated demyelinating disease as well as healthy controls will be recruited to undergo clinical testing. The study visits will include neuropsychological testing, optical coherence tomography (OCT) and MRI on both the 3T and 7T magnet. Subjects will be asked to undergo two study visits separated by 12 months to 18 months. Each study visit will have the same neuropsychological, OCT, and research MRI examinations.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| CNS demyelinating diagnosis | Diagnosis of CNS demyelinating disorder: Multiple Sclerosis, Transverse Myelitis, Neuromyelitis Optica, Acute Disseminated Encephalomyelitis, anti-MOG antibody, Optic Neuritis.
| ||
| Healthy Control |
|
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| Measure | Description | Time Frame |
|---|---|---|
| MRI Brain without contrast | 3T MRI | 10-14 months |
| MRI Brain without contrast | 7T MRI | 10-14 months |
| Change in Score of Delis-Kaplan Executive Function System (D-KEFS) Color | Executive Functioning | 10-14 months |
| Change in Score of Word Interference Test (CWIT) | Executive Functioning | 10-14 months |
| Change in Score of Symbol Digit Modalities (SDMT)- Oral Version | Processing Speed | 10-14 months |
| Change in Score of Beery-Buktencia Developmental Test of Visual-Motor Integration, Sixth Edition (VMI-6) | Visual-Motor Integration | 10-14 months |
| Change in Score of Wechsler Intelligence Scale for Children-5th edition (WISCV) | Simple Auditory Attention | 10-14 months |
| Change in Score of Wechsler Adult Intelligence Scale-Fourth edition (WAIS-IV) Digits Forward | Simple Auditory Attention | 10-14 months |
| Measure | Description | Time Frame |
|---|---|---|
| Change in Examination of Optical Coherence Tomography | Eye examination | 10-14 months |
| Change in PROMIS Mobility score | Patient Reported Outcomes Measures: Mobility, walking |
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Inclusion Criteria:
Exclusion Criteria:
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Teenagers before 22 at the time of consent diagnosis with a Central Nervous System demyelinating disorder.
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| Name | Affiliation | Role |
|---|---|---|
| Benjamin Greenberg, MD. MHS | University Texas Southwestern | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Texas Southwestern | Dallas | Texas | 75390 | United States |
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| Change in Score of WISC-V or WAIS-IV Digits Backward |
Working Memory |
| 10-14 months |
| Change in Score of California Verbal Learning Test- Children's Version (CVLT-C) or California Verbal Learning Test-Second Edition (CVLT-II) | Verbal Learning and Memory | 10-14 months |
| Change i Score of D-KEFS Letter and Category Fluency | Verbal Fluency | 10-14 months |
| Change in Score of WASI-II | Estimate of IQ | 10-14 months |
| Change in Score of Woodcock-Johnson Tests of Achievement Letter Word identification | Basic Reading Skill | 10-14 months |
| Change in Score of Reading Fluency | Reading Speed | 10-14 months |
| Change in Score of Calculation | Math Calculation Skills | 10-14 months |
| Change in Score of Math Fluency | Math Speed | 10-14 months |
| Change in Score of Word Attack | Phoneme/Grapheme Knowledge | 10-14 months |
| Change in Score of Grooved Pegboard | Bilateral Fine Motor Speed and Dexterity | 10-14 months |
| Change in Score of Trail Making Test, Part A and B | Simple and complex Attention | 10-14 months |
| Change in Score of Conners Continuous Performance Test 3rd Edition | Sustained Attention and Behavioral Inhibition | 10-14 months |
| 10-14 months |
| Change in PROMIS Pain score | Patient Reported Outcomes Measures: overall pain level | 10-14 months |
| Change in PROMIS Peer relationship score | Patient Reported Outcomes Measures: Peer relationships | 10-14 months |
| Change in PROMIS Stress score | Patient Reported Outcomes Measures: Psychological stress | 10-14 months |
| Change in PROMIS Upper extremity movement score | Patient Reported Outcomes Measures: Upper extremity movement | 10-14 months |
| Change in score of 25 foot timed walk | Walking speed | 10-14 months |
| Change in score of 6 minute timed walk | Walking Distance | 10-14 months |
| Change in score of Hauser Ambulation Index | Functional walking assessment | 10-14 months |
| Change in score of Multiple Sclerosis Functional Capacity (MSFC) | Hand and Eye coordination, Memory test | 10-14 months |
| Change in score of Modified Rankin Scale | Disability scale | 10-14 months |
| ID | Term |
|---|---|
| D020529 | Multiple Sclerosis, Relapsing-Remitting |
| D009471 | Neuromyelitis Optica |
| D004673 | Encephalomyelitis, Acute Disseminated |
| D009188 | Myelitis, Transverse |
| D009103 | Multiple Sclerosis |
| ID | Term |
|---|---|
| D020278 | Demyelinating Autoimmune Diseases, CNS |
| D020274 | Autoimmune Diseases of the Nervous System |
| D009422 | Nervous System Diseases |
| D003711 | Demyelinating Diseases |
| D001327 | Autoimmune Diseases |
| D007154 | Immune System Diseases |
| D009902 | Optic Neuritis |
| D009901 | Optic Nerve Diseases |
| D003389 | Cranial Nerve Diseases |
| D005128 | Eye Diseases |
| D056784 | Leukoencephalopathies |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D000094025 | Post-Infectious Disorders |
| D002908 | Chronic Disease |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D009187 | Myelitis |
| D002494 | Central Nervous System Infections |
| D007239 | Infections |
| D020361 | Paraneoplastic Syndromes, Nervous System |
| D009423 | Nervous System Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D010257 | Paraneoplastic Syndromes |
| D013118 | Spinal Cord Diseases |
| D019636 | Neurodegenerative Diseases |
| D000090862 | Neuroinflammatory Diseases |
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