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| Name | Class |
|---|---|
| Copenhagen University Hospital, Denmark | OTHER |
| Department of Otorhinolaryngology, Head and Neck Surgery and Audiology | UNKNOWN |
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This study investigates if head and neck squamous cell carcinoma can be tracked with cell-free tumor DNA, RNA or HPV-DNA, in blood samples from patients referred with suspicion of cancer, and if it can be used in detecting recurrence in patients already diagnosed and treated for head and neck squamous cell carcinoma.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Cell-free tumor DNA | Other | The aim is to differentiate between patients with head and neck cancer from those without based on a blood sample. |
|
| Identifying recurrence | Other | The aim is to identify recurrence through serial monitoring patients with blood samples. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Liquid biopsy | Diagnostic Test | The intervention is a liquid biopsy as a blood sample taken in a peripheral vein. The blood samples are analyzed for cell free DNA, RNA and HPV-DNA |
| Measure | Description | Time Frame |
|---|---|---|
| Percentage of head and neck cancer detected with a blood sample | The primary outcome is to measure the percentage of head and neck squamous cell carcinomas that can be detected using a liquid biopsy (blood sample) | 0 months |
| Percentage of head and neck cancer recurrence detected with a blood sample | The primary outcome is to measure the percentage of recurrence in head and neck cancer patients through serial monitoring with liquid biopsies (blood sample) | 36 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Christian Grønhøj, MD, Ph.D | Contact | 004526276374 | Christian.groenhoej@regionh.dk |
| Name | Affiliation | Role |
|---|---|---|
| Christian Von Buchwald, MD, DMSc | Department of Otorhinolaryngology, Head and Neck Surgery and Audiology | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital of Copenhagen, Rigshospitalet | Recruiting | Copenhagen | Capital Region | 2100 | Denmark |
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| ID | Term |
|---|---|
| D006258 | Head and Neck Neoplasms |
| D000077195 | Squamous Cell Carcinoma of Head and Neck |
| D009959 | Oropharyngeal Neoplasms |
| D009062 | Mouth Neoplasms |
| D007822 | Laryngeal Neoplasms |
| D000077274 | Nasopharyngeal Carcinoma |
| D009303 | Nasopharyngeal Neoplasms |
| D007012 | Hypopharyngeal Neoplasms |
| D013964 | Thyroid Neoplasms |
| D012468 | Salivary Gland Neoplasms |
| ID | Term |
|---|---|
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D002294 | Carcinoma, Squamous Cell |
| D002277 | Carcinoma |
| D009375 | Neoplasms, Glandular and Epithelial |
| D009370 | Neoplasms by Histologic Type |
| D010610 | Pharyngeal Neoplasms |
| D010039 | Otorhinolaryngologic Neoplasms |
| D010608 | Pharyngeal Diseases |
| D009057 | Stomatognathic Diseases |
| D010038 | Otorhinolaryngologic Diseases |
| D009059 | Mouth Diseases |
| D007818 | Laryngeal Diseases |
| D012140 | Respiratory Tract Diseases |
| D012142 | Respiratory Tract Neoplasms |
| D009302 | Nasopharyngeal Diseases |
| D004701 | Endocrine Gland Neoplasms |
| D004700 | Endocrine System Diseases |
| D013959 | Thyroid Diseases |
| D012466 | Salivary Gland Diseases |
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| ID | Term |
|---|---|
| D000073890 | Liquid Biopsy |
| ID | Term |
|---|---|
| D001706 | Biopsy |
| D003581 | Cytodiagnosis |
| D003584 | Cytological Techniques |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D013048 | Specimen Handling |
| D008919 | Investigative Techniques |
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