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end of funding support
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| Name | Class |
|---|---|
| University Hospital, Clermont-Ferrand | OTHER |
| Grenoble Institut des Neurosciences | OTHER |
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This study aims at identifying potential new and innovative biomarkers in de novo Parkinson's disease patients. New finding will help phenotyping patients since the diagnosis of the disease and potentially also in the preclinical phase.
The investigators will use 4 different approaches in parallel:
The investigators will integrate these 4 analysis using a mathematical paradigm in order to define specific phenotype of disease and disease progression.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Parkinson's disease patient | Other | Brain functional MRI, robotic TMS + EEG, neuropsychological evaluation, neurological examination for motor and non motor symptoms |
|
| Healthy controls | Other | Brain functional MRI, robotic TMS + EEG, neuropsychological evaluation, neurological examination |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Brain MRI | Procedure | 3 Tesla brain MRI for structural and perfusion evaluation, resting state analysis and functional MRI |
|
| Measure | Description | Time Frame |
|---|---|---|
| To compare cortical excitability differences between subjects | The EEG data after transcranial magnetic stimulation testing will be compared between parkinsonian patients and controls | In a seven months period after inclusion |
| To compare brain structural differences between subjects | All subjects will have a 3 Tesla brain MRI to collect data concerning anatomy. All data will be compared between patients and controls. Brain MRI study will consist in having the following sequences: T1 and T2, Fast Gray Matter Acquisition T1 Inversion Recovery (FGATIR) | In a seven months period after inclusion |
| To compare brain perfusional differences between subjects | All subjects will have a 3 Tesla brain MRI to collect data concerning perfusion. All data will be compared between patients and controls. Brain MRI study will consist in having the following sequences: Pseudo-Continuous Arterial Spin Labeling (PCASL), T2 with gadolinium, FLAIR | In a seven months period after inclusion |
| To compare brain connectivity differences between subjects | All subjects will have a 3 Tesla brain MRI to collect data concerning functional connectivity at rest. All data will be compared between patients and controls. Brain MRI study will consist in having the following sequences: Echo planar imaging (EPI) for the blood oxygen level-dependent effect | In a seven months period after inclusion |
| To compare emotional, attentional and behavior differences between subject | Subjects will be asked to comment on different pictures (if the picture induces pleasure, sorrow or nothing; what would the subjects do). Attentional parameters will be recorded using the Eye tracker. | In a seven months period after inclusion |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Elena Moro, MD, PhD | CHU Grenoble Alpes | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU Grenoble Alpes | Grenoble | 38043 | France |
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| ID | Term |
|---|---|
| D010300 | Parkinson Disease |
| ID | Term |
|---|---|
| D020734 | Parkinsonian Disorders |
| D001480 | Basal Ganglia Diseases |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
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| TMS-EEG | Procedure | Transcranial magnetic stimulation (TMS) coupled with electroencephalogram (EEG) study |
|
| Behavioral and cognitive battery | Behavioral | Emotional, attentional and behavioral assessment using predefine scales and measures |
|
| Clinical evaluation and clinical scales | Other | Neurological evaluation, ophthalmologic assessement, Montreal cognitive assessment (MoCA), movement disorder society (MDS)- UPDRS |
|
| To compare emotional, attentional and behavior differences between subject with functional MRI | During a functional MRI study, subjects will be asked to comment on different pictures (if the picture induces pleasure, sorrow or nothing; what would the subjects do). Attentional parameters will be recorded using the Eye tracker. | In a seven months period after inclusion |
| D009422 | Nervous System Diseases |
| D009069 | Movement Disorders |
| D000080874 | Synucleinopathies |
| D019636 | Neurodegenerative Diseases |