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| Name | Class |
|---|---|
| The Catholic University of Korea | OTHER |
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During one-lung ventilation in patients undergoing thoracic surgery, the persistent flow in the non-ventilated lung increases intrapulmonary shunt and decreases systemic arterial oxygenation. This prospective, randomized, double blind study was conducted to evaluate the effects of inhaled iloprost during one-lung ventilation on arterial oxygenation and shunt fraction during thoracic surgery.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Iloprost 10 | Experimental | Iloprost 10μg of inhaled iloprost (Ventavis®) Study drug was inhaled to ventilated lung through a nebulized system in inspiratory limb after one-lung ventilation in the lateral decubitus position. |
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| Iloprost 20 | Experimental | Iloprost 20μg of inhaled iloprost (Ventavis®) Study drug was inhaled to ventilated lung through a nebulized system in inspiratory limb after one-lung ventilation in the lateral decubitus position. |
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| Distilled water | Placebo Comparator | Distilled water Study drug was inhaled to ventilated lung through a nebulized system in inspiratory limb after one-lung ventilation in the lateral decubitus position. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Inhaled iloprost | Drug | Study drug was inhaled to ventilated lung through a nebulized system in inspiratory limb after one-lung ventilation in the lateral decubitus position. |
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| Measure | Description | Time Frame |
|---|---|---|
| PaO2(partial pressure of arterial oxygen) | ABGA | 30 min after treatment |
| Pulmonary shunt fraction | Qs/Qt = (CcO2-CaO2) / (CcO2-CvO2) | 30 min after treatment |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Wonjung Hwang | Seoul St. Mary's Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Seoul St.Mary's Hospital | Seoul | South Korea |
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| ID | Term |
|---|---|
| D008175 | Lung Neoplasms |
| ID | Term |
|---|---|
| D012142 | Respiratory Tract Neoplasms |
| D013899 | Thoracic Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
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| Distilled water | Drug | Study drug was inhaled to ventilated lung through a nebulized system in inspiratory limb after one-lung ventilation in the lateral decubitus position. |
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| D008171 |
| Lung Diseases |
| D012140 | Respiratory Tract Diseases |