The Effect of Iloprost on Oxygenation During One-lung Ventilation for Lung Surgery

The Effect of Iloprost on Arterial Oxygenation and Shunt Fraction During One-lung Ventilation for Lung Surgery

During one-lung ventilation in patients undergoing thoracic surgery, the persistent flow in the non-ventilated lung increases intrapulmonary shunt and decreases systemic arterial oxygenation. This prospective, randomized, double blind study was conducted to evaluate the effects of inhaled iloprost during one-lung ventilation on arterial oxygenation and shunt fraction during thoracic surgery.

Inclusion Criteria:

• elective video-assisted thoracoscopic surgery (VATS) lobectomy
• 20 < age < 75
• American Society of Anesthesiologists (ASA) classification I~III

Exclusion Criteria:

• ASA classification IV
• New York Heart Association (NYHA) class III~IV
• Severe obstructive lung disease / restrictive lung disease
• Pulmonary hypertension
• End-stage organ disease (i.e. hepatic failure, renal failure)
• Arrhythmia
• Previous history of thoracic surgery