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No patient wants to be recruited.
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Hyperthermic intraperitoneal chemotherapy is a major surgery for tumor peritoneal metastasis. For anesthesiologist, the intra-operative fluid control is always a big challenge. We try to compare the prognosis of lactate-directed and goal-directed therapy. We expect to confirm the better prognosis of lactate-directed therapy.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Lactate-directed therapy | Experimental |
| |
| Goal-directed therapy | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Lactate-directed therapy | Other | If the lactate level elevates, we transfuse pRBC to increase Hct>30%. If Hct >30%, dopamine infusion starts. |
|
| Measure | Description | Time Frame |
|---|---|---|
| pulmonary complication | X-ray findings of airspace or interstitial opacity, lobar consolidation, or pleural effusions; severe respiratory failure requiring respiratory support | 1 week |
| Measure | Description | Time Frame |
|---|---|---|
| Renal complication | oliguria with urine output<0.5 ml/kg/h for more than 4 h, creatinine increase>30 % of preoperative values, dialysis | 1 week |
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Inclusion Criteria:
Exclusion Criteria:
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| ID | Term |
|---|---|
| D009102 | Multiple Organ Failure |
| ID | Term |
|---|---|
| D012769 | Shock |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D000074388 | Early Goal-Directed Therapy |
| ID | Term |
|---|---|
| D003422 | Critical Care |
| D005791 | Patient Care |
| D013812 | Therapeutics |
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| Goal-directed therapy | Other | If SVV>15%, transfuse lactate ringer/normal saline alternatively to keep SVV<15%. |
|