Impact of Physical Activity on Cognitive Outcomes in Youth With Pediatric-Onset Multiple Sclerosis (POMS)

Impact of Physical Activity on Cognitive Outcomes in Youth With Pediatric-onset Multiple Sclerosis

The purpose of this study is to to determine how implementing a home-based virtual reality video (VR) game exercise program in young people with Multiple Sclerosis(MS) can improve disability outcomes by measuring its impact on cognitive assessments (BICAMS), subjective measures of cognitive, physical and psychosocial disability, and motor assessments (6MWT).

Inclusion Criteria:

• Confirmed diagnosis of Pediatric-Onset MS (<18 years) according to the 2017 revised McDonald criteria (relapsing-remitting)
• Expanded Disability Status Scale (EDSS) ≤ 5.0
• Relapse free for the past 30 days (including no corticosteroids)
• No contraindications to physical activity, including pregnancy
• Participant and parent (if between 15 and 18 years of age) written informed consent.

Exclusion Criteria:

• History of visual provoked seizures
• EDSS > 5.0