Vasopressin Injection Versus Misoprostol During Hysteroscopic Myomectomy In Reducing Blood Loss And Operation Time.

Efficacy of Transcervical Vasopressin Injection VersusVaginal Misoprostol During Hysteroscopic Myomectomy in Reducing Operative Blood Loss and Operation Time: A Randomized Trial.

A prospective randomized study designed to compare the efficacy of transcervical vasopressin injection versus vaginal misoprostol in reducing intra -operative blood loss during hysteroscopic mymectomy .

This was a prospective, randomized, study on forty women with symptomatic submucous myoma presented mostly with bleeding and/or infertility scheduled for hysteroscopic myomectomy were randomized to groups (group A) 20 patients transcervical intramyoma vasopressin injection and (group B) 20patients with vaginal misoprostol is used .

Inclusion Criteria:

• symptomatic women presented with bleeding or infertility and scheduled for hysterscopic myomectomy
• grade 0 and grade 1 submucous myomas
• less than 5 centimeters in diameter

Exclusion Criteria:

• Patients with grade 2 submucous myoma or more
• patients with submucous myomas larger than 5 cm in diameter
• postmenopausal women
• patients received GnRh analogue in last 6 months
• patients with anticoagulant therapy
• patients with endometrial premalignant or malignant pathologies
• patients with cardiovascular diseases, asthma or impaired kidney functions