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The brain protection effect of dexmedetomidine has been approved in several studies.
Basically, the anti-inflammatory effects and reducing catecholamines are thought to be a main role of the protection effect. In many studies reported the advantage of dexmedetomidine as a substitution of other sedative drugs for anesthesia.
The anesthesia of intra-cranial aneurysmal clipping operation commonly use intravenous anesthetic agents combined with inhalation anesthesia for neuroprotection, and mostly propofol is used.
The aim of this study is to examine the effects of dexmedetomidine on serum inflammatory markers and research the hemodynamic stability of dexmedetomidine compared to propofol in aneurysmal clipping operation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| propofol | Placebo Comparator |
| |
| dexmedetomidine | Active Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Dexmedetomidine | Drug | Dexmedetomidine 0.7 ug/kg/h with sevoflurane 0.5 MAC and remifentanil infusion are used throughout anesthesia period |
|
| Measure | Description | Time Frame |
|---|---|---|
| The concentration of inflammatory markers | CRP (mg/ml) | Baseline: Before injection study drugs |
| The concentration of inflammatory markers | CRP (mg/ml) | 1 minute after operation |
| The concentration of inflammatory markers | CRP (mg/ml) | Day 1 after operation |
| The concentration of inflammatory markers | CRP (mg/ml) | Day 2 after operation |
| The concentration of norepinephrine | NE (nmol/l) | Baseline: Before injection study drugs |
| The concentration of norepinephrine | NE (nmol/l) | 1 minute after operation |
| The concentration of norepinephrine | NE (nmol/l) | Day 1 after operation |
| The concentration of norepinephrine | NE (nmol/l) | Day 2 after operation |
| The concentration of inflammatory markers |
| Measure | Description | Time Frame |
|---|---|---|
| The frequency of hypotension or hypertension | during operation |
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Inclusion Criteria:
Exclusion Criteria:
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| ID | Term |
|---|---|
| D020927 | Dexmedetomidine |
| D015742 | Propofol |
| ID | Term |
|---|---|
| D007093 | Imidazoles |
| D001393 | Azoles |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
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| Propofol | Drug | Effect site concentration of propofol 1.5 ng/ml with sevoflurane 0.5 MAC and remifentanil infusion are used throughout anesthesia period |
|
IL-6, IL-8, IL-10 ,TNF-a (pg/ml)
| Baseline: Before injection study drugs |
| The concentration of inflammatory markers | IL-6, IL-8, IL-10 ,TNF-a (pg/ml) | 1 minute after operation |
| The concentration of inflammatory markers | IL-6, IL-8, IL-10 ,TNF-a (pg/ml) | Day 1 after operation |
| The concentration of inflammatory markers | IL-6, IL-8, IL-10 ,TNF-a (pg/ml) | Day 2 after operation |
| D010636 |
| Phenols |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |
| D009930 | Organic Chemicals |