Outpatient arthroscopic knee surgery can be performed with general or regional anesthesia. Recent data suggest that spinal and epidural anesthesia require longer discharge times than the newer shorter-acting general anesthetic drugs. Ideal premedication drug should relieve anxiety, produce amnesia and sedation, decrease secretions, prevent nausea and vomiting, have dose sparing effect on the anaesthetic drugs, and suppress pressor response to laryngoscopy and intubation. Recently, gabapentin and pregabalin were suggested as pre-operative drugs to decrease anxiety, stress response to laryngoscopy and post operative pain.

112 patients undergoing elective knee arthroscopy will randomly divided into two equal groups, 56 patients each. All patients will receive premedication one hour before the procedure. PG group will receive 150 mg pregabalin and C group will receive placebo. All patients will receive total intravenous anesthesia to achieve optimum working conditions. Intra-operative total amount of anesthetics will be compared in both groups.

Inclusion Criteria:

• Patients scheduled for elective knee arthroscopy.
• Patients aged between 21 and 50 years old.
• Patients with American Society of Anaesthesiologists physical status I or II.

Exclusion Criteria:

• Patients with known allergy to any drug used in the study.
• Patients with chronic use of analgesics and/or sedatives.
• Patients with sleep apnea syndrome.
• Patients with renal or hepatic dysfunction.
• Patients with psychiatric disorders.